The standard of care for major extremity fractures in patients with multiple injuries foresees early defi nitive fi xation of all major fractures. Recently controversial results were gathered from studies [1-7], and observations were made about certain patient sub-groups that developed unexpectedly high complication rates, when early definitive stabilization was performed. It was suggested that potential deleterious effects of internally fi xing long-bone fractures in the acute setting, where systemic hypo-perfusion and inflammation occurred, increases susceptibility to end-organ injury. In summary, three factors appeared to play a role that are pathogenetically connected:
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1.
Additional severe injuries (such as chest trauma)
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2.
Prolonged surgeries
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3.
The pre-operative condition [8, 9]
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Pape, HC. (2009). Damage-Control Orthopaedic Surgery in Polytrauma: Influence on the Clinical Course and Its Pathogenetic Background. In: Bentley, G. (eds) European Instructional Lectures. European Federation of National Associations of Orthopaedics and Traumatology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00966-2_8
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