Abstract
Changing point analysis in many dose finding tests has been applied to examine the change of a response with increasing dose levels of an experimental compound. In this study, we assume that the group observations at each dose level are sequentially obtain and a response shows a linear tendency at an early stage with increasing dose levels. Then we propose a sequential multiple comparison procedure to identify the minimum effective dose level to first separate from a linear response by sequentially comparing each dose level with the zero dose level. Furthermore, we present a formulation to determine a critical value, the power of the test and a procedure to determine the necessary sample size in our sequential test.
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© 2009 Springer-Verlag Berlin Heidelberg
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Douke, H., Nakamura, T. (2009). Sequential Multiple Comparison Procedure for Finding a Changing Point in Dose Finding Test. In: Gaul, W., Bock, HH., Imaizumi, T., Okada, A. (eds) Cooperation in Classification and Data Analysis. Studies in Classification, Data Analysis, and Knowledge Organization. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00668-5_15
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DOI: https://doi.org/10.1007/978-3-642-00668-5_15
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