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Adverse Drug Reactions Affecting Blood Cells

  • Richard H. AsterEmail author
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 196)

Abstract

Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter (“idiosyncratic”) reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated.

Keywords

Drug sensitivity Drug-induced cytrpennia 

Abbreviations

ADR

Adverse drug reaction

AITP

Autoimmune thrombocytopenic purpura

DDAb

Drug-dependent antibody

DIHA

Drug-induced immune hemolytic anemia

DITP

Drug-induced immune thrombocytopenia

G-CSF

Granulocyte colony simulating factor

HIT

Heparin-induced thrombocytopenia

HUS

Hemolytic uremic sundrome

NSAID

Non-steroidal anti-inflammatory drug

RGD

Arginine-glycine-aspartic acid

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Blood Research InstituteBlood Center of WisconsinMilwaukeeUSA

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