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Regenerative Wound Healing via Biomaterials

  • Chapter
Bioengineering Research of Chronic Wounds

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 1))

Abstract

Regenerative tissue engineering has the potential to revolutionize reconstructive approaches by providing either prefabricated tissue or responsive biomaterials with patient-specific geometry. The question to ask is how regeneration and repair are controlled in vivo and if a responsive biomaterial system can drive these processes? Does the cellular control lie at the cell-biomaterial nano-interface and do we have the tools to study this? The chemical and structural parameters and molecular linkages of the extracellular matrix that contribute to the internal mechanics of the cell and regulate a remodeling of an implanted biomaterial at the nano-interface have to be identified. This chapter is focused on introducing this concept of nano-scale regulated tissue regeneration by identifying numerous parameters of the biomaterial scaffold and cells so that the cell remodels the biomaterial without the addition of any growth factors, or other regulatory molecules by being influenced by composition, intermolecular linkages, nanostructure, nanomechanics of the biomaterial, and the biological/ chemical/ mechanical balance at the cell-biomaterial interface.

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Author information

Authors and Affiliations

  1. Tissue Regeneration and Molecular Cell Engineering Labs (TRAMCEL), Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX

    Anshu B. Mathur

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  1. Anshu B. Mathur
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Editors and Affiliations

  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, 69978, Ramat Aviv, Israel

    Amit Gefen

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Mathur, A.B. (2009). Regenerative Wound Healing via Biomaterials. In: Gefen, A. (eds) Bioengineering Research of Chronic Wounds. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00534-3_18

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  • DOI: https://doi.org/10.1007/978-3-642-00534-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-00533-6

  • Online ISBN: 978-3-642-00534-3

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