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Drug Delivery pp 221–250Cite as

Pharmaceutically Used Polymers: Principles, Structures, and Applications of Pharmaceutical Delivery Systems

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 197))

Abstract

This chapter presents a general overview of pharmaceutically used polymers with respect to their physicochemical characteristics and factors affecting drug delivery abilities. Pharmaceutical polymers, chemical structure, and properties are discussed for their applications in controlled drug release systems. An additional focus is on new polymers (dendrimers, hyperbranched polymers), considering their chemical versatility, uniqueness, and future implications. Problems associated with controlled drug release systems are also highlighted. Finally, applications of FDA-approved polymers used for oral drug delivery systems are outlined.

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Abbreviations

Ab:

Antibody

API:

Active pharmaceutical ingredient

C max :

Concentration maximum

CRS:

Controlled released system

DDS:

Drug delivery system

EPR:

Enhanced permeability and retention

FDA:

Food and Drug Administration (USA)

G2 (PAMAM):

Generation 2 polyamidoamine dendrimers

GR:

Gastro-retentive delivery systems

HPMA:

N-(2-Hydroxypropyl)methacrylamide

HPMC:

Hydroxypropylmethylcellulose

IgG:

Human immunoglobulinG

M w :

Molecular weight

mPEG-OH:

Polyethylene glycol monomethyl ether

PAA:

Poly(acrylic acid)

PAMAM:

Polyamidoamine

PDDS:

Pulsatile drug delivery system

PDI:

Polydispersity index

PEG:

Poly(ethylene glycol)

PEO:

Poly(ethylene oxide)

PGA:

Poly(glutamic acid)

pk a :

Acid dissociation constant

PLA:

Polylactic acid

PLGA:

poly(lactic-co-glycolic acid) copolymer

PMMA:

Polymethylmethacrylate

PVA:

Poly vinyl alcohol

RES:

Reticular endothelium system

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Authors and Affiliations

  1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany

    Rainer Haag

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  1. Jayant Khandare
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  2. Rainer Haag
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Correspondence to Rainer Haag .

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  1. FB Biologie, Chemie, Pharmazie, Inst. Pharmazie, FU Berlin, Königin-Luise-Str. 2-4, Berlin, 14195, Berlin, Germany

    Monika Schäfer-Korting

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Khandare, J., Haag, R. (2010). Pharmaceutically Used Polymers: Principles, Structures, and Applications of Pharmaceutical Delivery Systems. In: Schäfer-Korting, M. (eds) Drug Delivery. Handbook of Experimental Pharmacology, vol 197. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00477-3_8

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