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Pulmonary Drug Delivery: Medicines for Inhalation

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Drug Delivery

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 197))

Abstract

Mankind has inhaled substances for medical and other reasons for thousands of years, notably resulting in the cultural manifestations of tobacco and opium smoking. Over the course of time concepts of pulmonary application, including inhalation devices and drug formulations, have been and still are being continuously developed. State of the art instruments even allow for individualized drug application by adaption of the inhalation procedure to the breathing pattern of the patient. Pulmonary drug delivery offers promising advantages in comparison to “classical” drug administration via the oral or transcutaneous routes, which is also reflected by an increasing interest and number of marketed products for inhalation therapy. However, the lungs’ efficient clearance mechanisms still limit the benefit of many therapeutic concepts. In consequence the objective of current research and development in pulmonary drug delivery is to overcome and to control drug clearance from the intended target site. Here, several of the most auspicious future drug delivery concepts are presented and discussed in order to give the reader an insight into this emerging field of medicine.

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Abbreviations

2-OMR:

Antisense oligonucleotide 2′-O-methyl-RNA

A549:

Lung cancer cell line (CCL-185; ATCC)

APCs:

Antigen-presenting cells

ATD:

Anti-tubercular drugs

AUC:

Area under the curve

BALT:

Broncho-alveolar lymphoid tissue

Calu-3:

Human epithelial-like lung cancer cell line (HTB-55; ATCC)

CF:

Cystic fibrosis

CFTR:

Cystic fibrosis transmembrane conductance regulator

CLIJ:

Confined liquid impinging jet

COPD:

Chronic obstructive pulmonary disease

DOTAP:

N-[1-(2,3-Dioleoyloxy)]-N, N, N-trimethylammonium propane methylsulphate

DPI:

Dry powder inhaler

DPLC:

Dipropionate-dilauroylphosphatidylcholine

DPPC:

Dipalmitoyl-phosphatidylcholine

DSPC:

Distearoyl-phosphatidylcholine

DSPE:

Distearoyl-phosphatidylethanolamine

FDA:

U.S. Food and Drug Administration

ICRP:

International Commission on Radiological Protection

MC:

Mucociliary clearance

MDI:

Metered-dose inhaler

PEG:

Polyethylenglycol

PEI:

Polyethylenimine

PLGA:

Poly-lactide-co-glycolide

PTEN:

Phosphatase and tensin homolog: tumor suppressor gene

siRNA:

Small interfering RNA

SLIT:

Sustained release lipid inhalation targeting

SLM:

Solid lipid microparticle

TAT:

Human immunodeficiency virus-1 transactivator protein

WHO:

World Health Organization

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Authors and Affiliations

  1. Biopharmaceutics and Pharmaceutical Technology, Saarland University, 15 11 50, 66041, Saarbrücken, Germany

    Claus-Michael Lehr

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  1. Andreas Henning
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  2. Stephanie Hein
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  3. Marc Schneider
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  4. Michael Bur
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  5. Claus-Michael Lehr
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Correspondence to Claus-Michael Lehr .

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  1. FB Biologie, Chemie, Pharmazie, Inst. Pharmazie, FU Berlin, Königin-Luise-Str. 2-4, Berlin, 14195, Berlin, Germany

    Monika Schäfer-Korting

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Henning, A., Hein, S., Schneider, M., Bur, M., Lehr, CM. (2010). Pulmonary Drug Delivery: Medicines for Inhalation. In: Schäfer-Korting, M. (eds) Drug Delivery. Handbook of Experimental Pharmacology, vol 197. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00477-3_6

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