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Improving Oral Delivery

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Drug Delivery

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 197))

Abstract

It is estimated that 90% of all medicines are oral formulations and their market share is still increasing, due to sound advantages for the patient, the pharmaceutical industry and healthcare systems. Considering biopharmaceutical issues such as physicochemical requirements of the drug and physiological conditions, however, oral delivery is one of the most challenging routes. Recognising solubility, permeability and residence time in the gastrointestinal milieu as key parameters, different characteristics of drugs and their delivery systems such as size, pH, density, diffusion, swelling, adhesion, degradation and permeability can be adjusted to improve oral delivery. Future developments will focus on further improvement in patient compliance as well as the feasibility of administering biotech drugs via the oral route.

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Abbreviations

AAL:

Aleuria aurantia lectin

API:

Active pharmaceutical ingredient

BCS:

Bioclassification System

EGF:

Epidermal growth factor

EOP:

Elementary osmotic pump

EPAS:

Evaporative precipitation into aqueous solution

FAE:

Follicle associated epithelium

FDA:

Food and drug administration

FDDS:

Floating drug delivery system

GALT:

Gut-associated lymphoid tissue

GI:

Gastrointestinal

GRAS:

Generally recognised as safe

HBS:

Hydrodynamically balanced system

HEC:

Hydroxyethyl cellulose

HPMC:

Hydroxypropylmethyl cellulose

IBD:

Inflammatory bowel diseases

LEA:

Lycopersicum esculentum agglutinin

MC:

Methyl cellulose

OPV:

Oral poliovirus vaccine

PEG:

Polyethylene glycol

PVP:

Polyvinylpyrrolidone

SFL:

Spray freezing into liquid

SOTS:

Sandwiched osmotic tablet system

UEA:

Ulex europaeus agglutinin

WGA:

Wheat germ agglutinin

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  1. Department of Pharmaceutical Technology and Biopharmaceutics, Universität Wien, Althanstrasse 14, A-1090, Vienna, Austria

    Franz Gabor

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  1. Franz Gabor
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  2. Christian Fillafer
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  3. Lukas Neutsch
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  4. Gerda Ratzinger
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  5. Michael Wirth
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  1. FB Biologie, Chemie, Pharmazie, Inst. Pharmazie, FU Berlin, Königin-Luise-Str. 2-4, Berlin, 14195, Berlin, Germany

    Monika Schäfer-Korting

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Gabor, F., Fillafer, C., Neutsch, L., Ratzinger, G., Wirth, M. (2010). Improving Oral Delivery. In: Schäfer-Korting, M. (eds) Drug Delivery. Handbook of Experimental Pharmacology, vol 197. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00477-3_12

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