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Novel Strategies for the Treatment of Brain Cancer

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Therapeutic Ribonucleic Acids in Brain Tumors

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Abstract

This chapter deals with innovations in the treatment of glioblastoma multiforme (GBM) based on current concepts of molecular pathogenesis. Limitations of the current therapy are pointed out. Targets for the innovative therapies are listed and antiangiogenesis strategies as well as methods of therapeutic delivery, including crossing the blood–brain tumor barrier are discussed. Personalized approaches are described that enable selection of the best treatment suited for an individual. Molecular therapies including vaccines, cell therapy, and RNA interference (RNAi) are promising for the future efforts to find a cure for GBM. The usefulness of genetically modified bacteria as a tool to destroy GBM is emphasized.

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Abbreviations

EGFR:

Endothelial growth factor receptor

MMP:

Matrix metalloprotease

PI3K:

Phosphatidylinositol-3-kinase

PARP:

Poly(ADP-ribose) polymerase

PDGFR:

Platelet-derived growth factor receptor

TNF-α:

Tumor necrosis factor-α

VEGF:

Vascular endothelial growth factor

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Author information

Authors and Affiliations

  1. Jain PharmaBiotech., Blaesiring 7, 4057, Basel, Switzerland

    Kewal K. Jain

Authors
  1. Kewal K. Jain
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Corresponding author

Correspondence to Kewal K. Jain .

Editor information

Editors and Affiliations

  1. Inst. Chemie und Biochemie, FU Berlin, Thielallee 63, Berlin, 14195, Germany

    Volker A. Erdmann

  2. Inst. Neuropathologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany

    Guido Reifenberger

  3. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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© 2009 Springer-Verlag Berlin Heidelberg

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Jain, K.K. (2009). Novel Strategies for the Treatment of Brain Cancer. In: Erdmann, V., Reifenberger, G., Barciszewski, J. (eds) Therapeutic Ribonucleic Acids in Brain Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00475-9_4

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