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Peroxisomes as a Cellular Source of ROS Signal Molecules

  • Luis A. del  RíoEmail author
  • Luisa M. Sandalio
  • Francisco J. Corpas
  • María C. Romero-Puertas
  • José M. Palma
Chapter
Part of the Signaling and Communication in Plants book series (SIGCOMM)

Abstract

Peroxisomes are subcellular organelles with an essentially oxidative type of metabolism and devoid of DNA, and are probably the major sites of intracellular H2O2 production. Like mitochondria and chloroplasts, peroxisomes also produce superoxide radicals (O2) and there are, at least, two sites of superoxide generation: one in the organelle matrix, the generating system being xanthine oxidase, and another site in the peroxisomal membranes dependent on NAD(P)H. In peroxisomal membranes, three integral polypeptides (PMPs) have been shown to generate O2 radicals. Besides catalase, several antioxidative enzymes have been demonstrated in plant peroxisomes, including different superoxide dismutases, the enzymes of the ascorbate–glutathione cycle plus ascorbate and glutathione, and three NADP-dependent dehydrogenases. The presence of nitric oxide synthase (NOS) activity and its reaction product, nitric oxide (NO), has been demonstrated in plant peroxisomes. These organelles have a ROS-mediated cellular function in leaf senescence and in stress situations induced by xenobiotics and heavy metals, and can have an important role in plant cells as a source of signal molecules like O2 radicals, H2O2, NO and S-nitrosoglutathione (GSNO).

Keywords

Nitric Oxide Xanthine Oxidase Glutathione Cycle Peroxisomal Membrane Monodehydroascorbate Reductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by research projects from the Ministry of Education and Science (grants PB98-0493-01 and BFI 2002-04440-01), Spain, Research Training Network grants from the European Commission (contracts CHRX-CT94-0605 and HPRN-CT-2000-00094) and Junta de Andalucía (Group BIO-0192 and project P06-CVI-01820).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Luis A. del  Río
    • 1
    Email author
  • Luisa M. Sandalio
    • 1
  • Francisco J. Corpas
    • 1
  • María C. Romero-Puertas
    • 1
  • José M. Palma
    • 1
  1. 1.Departamento de Bioquímica, Biología Celular y Molecular de Plantas,Estación Experimental del ZaidínConsejo Superior de Investigaciones Científicas (CSIC)GranadaSpain

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