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Autophagy in Infection and Immunity pp 287–306Cite as

Something Old, Something New: Plant Innate Immunity and Autophagy

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 335))

Abstract

Autophagy performs a variety of established functions during plant growth and development. Recently, autophagy has been further implicated in the regulation of programmed cell death induced during the plant innate immune response. In this chapter we describe specific mechanisms through which autophagy may contribute to a successful defense against pathogen invasion. Accumulating evidence shows that the plant immune system utilizes the chloroplasts as primary sites for the regulation of cell death programs. Viruses also appear to utilize the chloroplast as a site of replication and accumulation, potentially inactivating chloroplast defense signaling in the process. Autophagy-like mechanisms have been observed to target the chloroplast, which we refer to as “chlorophagy,” potentially targeting invasive viruses for degradation or regulating chloroplast-based signaling during the immune response. We hypothesize that chlorophagy is significant for the execution of plant immune defenses, during both basal and effector-triggered immunity.

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Acknowledgments

NIH and NSF grants support autophagy work in the Dinesh-Kumar lab.

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Authors and Affiliations

  1. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520-8103, USA

    Montrell Seay, Andrew P. Hayward, Jeffrey Tsao & S. P. Dinesh-Kumar

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  1. Montrell Seay
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  2. Andrew P. Hayward
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  4. S. P. Dinesh-Kumar
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Correspondence to S. P. Dinesh-Kumar .

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Editors and Affiliations

  1. Southwestern Medical Center, University of Texas, Harry Hines Blvd. 5323, Dallas, 75390-9113, U.S.A.

    Beth Levine

  2. Research Inst. Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka, 565-0871, Japan

    Tamotsu Yoshimori

  3. Health Sciences Center, University of New Mexico, Camino de Salud NE., 915, Albuquerque, 87131, U.S.A.

    Vojo Deretic

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Seay, M., Hayward, A.P., Tsao, J., Dinesh-Kumar, S.P. (2009). Something Old, Something New: Plant Innate Immunity and Autophagy. In: Levine, B., Yoshimori, T., Deretic, V. (eds) Autophagy in Infection and Immunity. Current Topics in Microbiology and Immunology, vol 335. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00302-8_14

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