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Signaling Pathways in Biliary Epithelial Cells

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Signaling Pathways in Liver Diseases

Abstract

Biliary epithelial cells, or cholangiocytes, line the lumen of the biliary tree. Like hepatocytes, cholangiocytes are a polarized epithelium with structural features that include well-defined apical and basolateral membrane domains. Cholangiocytes constitute approximately 5% of the mass of the liver and play an important role in the formation of bile by altering primary canalicular bile through a series of secretory and reabsorptive events. These events are regulated by peptide hormones, nucleotides, bile salts, growth factors, cytokines, and neurotransmitters that bind to and stimulate specific apical or basolateral surface membrane receptors, which in turn initiate intracellular signal transduction pathways that regulate cell function. In addition to their role in the modification of ductal bile, cholangiocytes participate in the detoxification of xenobiotics [1].

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Acknowledgments

This work was supported by NIH grants TW01451, DK61747, DK45710, DK34989, and DK57751 and by a grant from the Howard Hughes Medical Institute.

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  1. Department of Medicine, Yale University School of Medicine, 1 Gilbert Street, New Haven, CT, 06520-8019, USA

    M. Fatima Leite, Viviane A. Andrade & Michael H. Nathanson

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  1. M. Fatima Leite
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  2. Viviane A. Andrade
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  3. Michael H. Nathanson
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Correspondence to Michael H. Nathanson .

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  1. Inselspital, Universität Bern, Murtenstr. 35, Bern, 3010, Switzerland

    Jean-Francois Dufour

  2. Klinik für Viszeral- und, Universitätsspital Zürich, Rämistr. 100, Zürich, 8091, Switzerland

    Pierre-Alain Clavien

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Leite, M.F., Andrade, V.A., Nathanson, M.H. (2010). Signaling Pathways in Biliary Epithelial Cells. In: Dufour, JF., Clavien, PA. (eds) Signaling Pathways in Liver Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_2

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