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Signaling Pathways in Liver Diseases pp 215–227Cite as

JNKs in liver diseases

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Abstract

c-Jun NH2-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family. Like other MAPKs, JNKs are conserved throughout eukaryotic evolution, activated via three-tiered phosphorylation cascades, and involved in a wide range of cellular responses to stress. JNKs have been shown to play important roles in proliferation, cell death, inflammation and cell metabolism. These seemingly unrelated responses are part of an overall stress response program that ensures proper repair of cells sustaining minor damage, elimination of cells sustaining irreversible structural or genetic damage, as well as their proper replacement.

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Acknowledgements

This work was supported by NIH grants R01DK076920 and U54CA126513.

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  1. Department of Medicine, columbia University, Russ Berrie Pavilion, Room 415, 1150 St. Nicholas Avenue, 10032, New York, NY, USA

    R. Schwabe

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  1. Inselspital, Universität Bern, Murtenstr. 35, Bern, 3010, Switzerland

    Jean-Francois Dufour

  2. Klinik für Viszeral- und, Universitätsspital Zürich, Rämistr. 100, Zürich, 8091, Switzerland

    Pierre-Alain Clavien

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Schwabe, R. (2010). JNKs in liver diseases. In: Dufour, JF., Clavien, PA. (eds) Signaling Pathways in Liver Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_14

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