Abstract
Syndactyly type Lueken is characterized by variable syndactyly of the digits of the hands and feet. The least severely affected show syndactyly type I, also called zygodactyly, a term referring to complete or partial webbing between digits III and IV and/or complete or partial webbing between toes II and III. In the most severe cases, there is complete syndactyly of fingers II–V, the thumb is spared, and there is syndactyly of all toes, including the hallux. In severe cases, bony fusion of the distal phalanges can be observed. Penetrance is incomplete.
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References
Bosse K, Betz RC, Lee Y-A, Wienker TF, Reis A, Kleen H et al (2000) Localization of a gene for syndactyly type 1 to chromosome 2q34-q36. Am J Hum Genet 67:492–497
Klopocki E, Lohan S, Brancati F, Koll R, Brehm A, Seemann P et al (2011) Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis. Am J Hum Genet 88:70–75
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© 2014 Springer-Verlag Berlin Heidelberg
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Mundlos, S., Horn, D. (2014). Syndactyly Type Lueken. In: Limb Malformations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-95928-1_19
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DOI: https://doi.org/10.1007/978-3-540-95928-1_19
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-95927-4
Online ISBN: 978-3-540-95928-1
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