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The Liver as an Immune Organ

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Clinical Hepatology

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References

  1. Aleffi S, Petrai I, Bertolani C, et al (2005) Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 42: 1339–48

    Article  CAS  PubMed  Google Scholar 

  2. Bertolino P, Klimpel G, Lemon SM (2000) Hepatic inflam-mation and immunity: a summary of a conference on the function of the immune system within the liver. Hepatology 31: 1374–8

    Article  CAS  PubMed  Google Scholar 

  3. Crispe IN, Mehal WZ (1996) Strange brew: T cells in the liver. Immunol Today 17: 522–5

    Article  CAS  PubMed  Google Scholar 

  4. Crosbie OM, Reynolds M, McEntee G, et al (1999) In vitro evidence for the presence of hematopoetic stem cells in the adult human liver. Hepatology 29: 1193–8

    Article  CAS  PubMed  Google Scholar 

  5. De Creus A, Abe M, Lau AH, et al (2005) Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol 174: 2037–45

    CAS  PubMed  Google Scholar 

  6. Doherty DG, O'Farrelly C (2000) Innate and adaptive lym-phoid cells in the human liver. Immunol Rev 174: 5–20

    Article  CAS  PubMed  Google Scholar 

  7. Doherty DG, O'Farrelly C (2001) Dendritic cells: regulators of hepatic immunity or tolerance? J Hepatology 34: 156–60

    Article  CAS  Google Scholar 

  8. Edwards S, Lalor PF, Nash GB, et al (2005) Lymphocyte traffic through sinusoidal endothelial cells is regulated by hepatocytes. Hepatology 41: 451–9

    Article  PubMed  Google Scholar 

  9. Exley MA, Koziel MJ (2004) To be or not to be NKT: natural killer T cells in the liver. Hepatology 40: 1033–40

    Article  PubMed  Google Scholar 

  10. Gabay C, Kushner I (1999) Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340: 448–54

    Article  CAS  PubMed  Google Scholar 

  11. Heinrich PC, Castell JV, Andus T (1990) Interleukin-6 and the acute phase response. Biochem J 265: 621–36

    CAS  PubMed  Google Scholar 

  12. Jonsson JR, Edwards-Smith CJ, Catania SC, et al (2000) Expression of cytokines and factors modulating apoptosis by human sinusoidal leukocytes. J Hepatol 32: 392–8

    Article  CAS  PubMed  Google Scholar 

  13. Karrar A, Broome U, Uzunel M, et al (2007) Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut 243–52

    Google Scholar 

  14. Kita H, Mackay IR, van de Water J, et al (2001) The lym-phoid liver: considerations on pathways to autoimmune injury. Gastroenterology 120: 1485–501

    Article  Google Scholar 

  15. Knolle PA (2006) Involvement of the liver in the induction of CD8 T cell tolerance towards oral antigen. Z Gastroenterol 44: 51–6

    Article  CAS  PubMed  Google Scholar 

  16. Lau AH, de Creus A, Thomson AW (2003) Liver tolerance mediated by antigen presenting cells: fact or fiction? Gut 52: 1075–8

    Article  CAS  PubMed  Google Scholar 

  17. Lau AH, Thomson (2003) Dendritic cells and immune regulation in the liver. Gut 52: 307–14

    Article  CAS  PubMed  Google Scholar 

  18. Mehal WZ, Azzaroli F, Crispe N (2001) Immunology of the healthy liver: old questions and new insights. Gastro-enterology 120: 250–60

    Article  CAS  Google Scholar 

  19. Peters M, Vierling J, Gershwin ME, et al (1991) Immunology and the liver. Hepatology 13: 977–94

    Article  CAS  PubMed  Google Scholar 

  20. Peters M (1996) Actions of cytokines on the immune response and viral interactions: an overview. Hepatology 23: 909–16

    Article  CAS  PubMed  Google Scholar 

  21. Prickett TC, McKenzie JL, Hart DN (1988) Characterisation of interstitial dendritic cells in human liver. Transplantation 46: 754–61

    Article  CAS  PubMed  Google Scholar 

  22. Recanelli V, Rehermann B (2006) The liver as an immuno-logical organ. Hepatology 43: S54–62

    Article  Google Scholar 

  23. Reynoso-Paz S, Coppel RL, Mackay IR, et al (1999) The immunobiology of bile and biliary epithelium. Hepatology 30: 351–7

    Article  Google Scholar 

  24. Schwabe RF, Seki E, Brenner DA (2006) Toll-like receptor signaling in the liver. Gastroenterology 130: 1886–900

    Article  CAS  PubMed  Google Scholar 

  25. Seki S, Habu Y, Kawamura T, et al (2000) The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag + T cells in T helper 1 immune responses. Immunol Rev 174: 35–46

    Article  CAS  PubMed  Google Scholar 

  26. Selmi C, Mackay IR, Gershwin ME (2007) The immuno-logical milieu of the liver. Semin Liv Dis 27: 129–39

    Article  CAS  Google Scholar 

  27. Simpson KJ, Lukacs NW, Colletti L, et al (1997) Cytokines and the liver. J Hepatol 27: 1120–32

    Article  CAS  PubMed  Google Scholar 

  28. Szabo G, Dolgianuc A, Mandrekar P (2006) Pattern recognition receptors: a contemporary view on liver diseases. Hepatology 44: 287–98

    Article  CAS  PubMed  Google Scholar 

  29. Trautwein C, Böker K, Manns MP (1994) Hepatocyte and immune system: acute phase reaction as a contribution to early defence mechanisms. Gut 35: 1163–6

    Article  CAS  PubMed  Google Scholar 

  30. Warren A, Le Couteur DG, Fraser R, et al (2006) T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology 44: 1182–90

    Article  CAS  PubMed  Google Scholar 

  31. Welsh RM, Lin MY, Lohman BL, et al (1997) Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections. Immunol Rev 159: 79–93

    Article  CAS  PubMed  Google Scholar 

  32. Winnock M, Garcia Barcina M, Lukomska M, et al (1995) Human liver-associated lymphocytes: an overview. J Gastro-enterol Hepatol 10: S43–6

    Article  Google Scholar 

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Dancygier, H. (2010). The Liver as an Immune Organ. In: Clinical Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-93842-2_11

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  • DOI: https://doi.org/10.1007/978-3-540-93842-2_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-93841-5

  • Online ISBN: 978-3-540-93842-2

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