Abstract
Following the first detection of the highly pathogenic H5N1 avian influenza virus in sick geese in Guangdong Province in China in 1996, scientists began to develop vaccines in preparation for an avian influenza pandemic. An inactivated H5N2 vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, and was used for buffer zone vaccination during H5N1 outbreaks in 2004 in China. We also generated a low pathogenic H5N1 reassortant virus (Re-1) that derives its HA and NA genes from the GS/GD/96 virus and six internal genes from the high-growth A/Puerto Rico/8/34 (PR8) virus using plasmid-based reverse genetics. The inactivated vaccine derived from the Re-1 strain could induce more than ten months of protective immunity in chickens after one-dose inoculation; most importantly, this vaccine is immunogenic for geese and ducks. We recently developed a Newcastle virus-vectored live vaccine that exhibits great promise for use in the field to prevent highly pathogenic avian influenza and Newcastle disease in chickens. Over 30 billion doses of these vaccines have been used in China and other countries, including Vietnam, Mongolia, and Egypt, and have played an important role in H5N1 avian influenza control in these countries.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Reference
Babiuk LA (1999) Broadening the approaches to developing more effective vaccines. Vaccine 17:1587–1595
Capua I, Marangon S, dalla Pozza M, Terregino C, Cattoli G (2003) Avian influenza in Italy 1997–2001. Avian Dis 47:839–843
Chen H, Yu K, Jiang Y, Tang X (2001). DNA immunization elicits high HI antibody and protects chicken from AIV challenge. Options for the control of influenza IV, Crete, Greece, 23–28 Sept 2000, 1219:917–921
Chen H, Deng G, Li Z, Tian G, Li Y, Jiao P, Zhang L, Liu Z, Webster RG, Yu K (2004) The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci USA 101:10452–10457
Chen H, Li Y, Li Z, Shi J, Shinya K, Deng G, Qi Q, Tian G, Fan S, Zhao H, Sun Y, Kawaoka Y (2006) Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J Virol 80:5976–5983
Donnelly JJ, Liu MA, Ulmer JB (2000) Antigen presentation and DNA vaccines. Am J Respir Crit Care Med 162:S190–S193
Ellis TM, Leung CY, Chow MK, Bissett LA, Wong W, Guan Y, Malik Peiris JS (2004) Vaccination of chickens against H5N1 avian influenza in the face of an outbreak interrupts virus transmission. Avian Pathol 33:405–412
Fodor E, Devenish L, Engelhardt OG, Palese P, Brownlee GG, Garcia-Sastre A (1999) Rescue of influenza A virus from recombinant DNA. J Virol 73:9679–9682
Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL (1993) DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 90:11478–11482
Garmory HS, Brown KA, Titball RW (2003) DNA vaccines: improving expression of antigens. Genet Vaccines Ther 1:2
Ge J, Deng G, Wen Z, Tian G, Wang Y, Shi J, Wang X, Li Y, Hu S, Jiang Y, Yang C, Yu K, Bu Z, Chen H (2007) Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. J Virol 81:150–158
Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG (2000) A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci USA 97:6108–6113
Jiang Y, Yu K, Zhang H, Zhang P, Li C, Tian G, Li Y, Wang X, Ge J, Bu Z, Chen H (2007) Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector. Antiviral Res 75:234–241
Li S, Liu C, Klimov A, Subbarao K, Perdue ML, Mo D, Ji Y, Woods L, Hia S, BryantMet al (1999) Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses. J Infect Dis 179:1132–1138
Li C, Ping J, Jing B, Deng G, Jiang Y, Li Y, Tian G, Yu K, Bu Z, Chen H (2008) H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochem Biophys Res Commun 3722:293–297
Liu MA, Fu TM, Donnelly JJ, Caulfield MJ, Ulmer JB (1998) DNA vaccines. Mechanisms for generation of immune responses. Adv Exp Med Biol 452:187–191
Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang XW, Zhang XL, Zhao D, Wang G, Feng Y, Ma J, Liu W, Wang J, Gao GF (2005) Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309:1206
Neumann G, Watanabe T, Ito H, Watanabe S, Goto H, Gao P, Hughes M, Perez DR, Donis R, Hoffmann E, Hobom G, Kawaoka Y (1999) Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci USA 96:9345–9350
Perdue ML, Garcia M, Senne D, Fraire M (1997) Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses. Virus Res 49:173–186
Qiao CL, Yu KZ, Jiang YP, Jia YQ, Tian GB, Liu M, Deng GH, Wang XR, Meng QW, Tang XY (2003) Protection of chickens against highly lethal H5N1 and H7N1 avian influenza viruses with a recombinant fowlpox virus co-expressing H5 haemagglutinin and N1 neuraminidase genes. Avian Pathol 32:25–32
Senne DA, Panigrahy B, Kawaoka Y, Pearson JE, Suss J, Lipkind M, Kida H, Webster RG (1996) Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis 40:425–437
Sharma S, Mamane Y, Grandvaux N, Bartlett J, Petropoulos L, Lin R, Hiscott J (2000) Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes. AIDS Res Hum Retroviruses 16:1613–1622
Suarez DL, Schultz-Cherry S (2000) The effect of eukaryotic expression vectors and adjuvants on DNA vaccines in chickens using an avian influenza model. Avian Dis 44:861–868
Subbarao K, Chen H, Swayne D, Mingay L, Fodor E, Brownlee G, Xu X, Lu X, Katz J, Cox N, Matsuoka Y (2003) Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology 305:192–200
Swayne DE, Garcia M, Beck JR, Kinney N, Suarez DL (2000) Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert. Vaccine 18:1088–1095
Tian G, Zhang S, Li Y, Bu Z, Liu P, Zhou J, Li C, Shi J, Yu K, Chen H (2005) Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics. Virology 341:153–162
van der Goot JA, Koch G, de Jong MC, van Boven M (2005) Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens. Proc Natl Acad Sci USA 102:18141–18146
Wan XF, Ren T, Luo KJ, Liao M, Zhang GH, Chen JD, Cao WS, Li Y, Jin NY, Xu D, Xin CA (2005) Genetic characterization of H5N1 avian influenza viruses isolated in southern China during the 2003–04 avian influenza outbreaks. Arch Virol 150:1257–1266
Webster RG (1999) Potential advantages of DNA immunization for influenza epidemic and pandemic planning. Clin Infect Dis 28:225–229
Acknowledgment
The authors are supported by the Animal Infectious Disease Control Program of the Ministry of Agriculture, and the Chinese National S&T Plan Grants 2004BA519A-57 and 2006BAD06A05.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chen, H., Bu, Z. (2009). Development and Application of Avian Influenza Vaccines in China. In: Compans, R., Orenstein, W. (eds) Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology, vol 333. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92165-3_7
Download citation
DOI: https://doi.org/10.1007/978-3-540-92165-3_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-92164-6
Online ISBN: 978-3-540-92165-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)