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Transcutaneous Immunization with Influenza Vaccines

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Book cover Vaccines for Pandemic Influenza

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 333))

Abstract

Transcutaneous immunization (TCI) is a novel vaccination route involving the topical application of vaccine antigens on the skin. The skin is an attractive site for vaccination because it is rich in various antigen-capturing immune cells. The outer skin barrier can be overcome through the use of mild chemical and/or physical treatments, including ethanol–water hydration and stripping, which allows for large vaccine molecules or even particulate antigens to gain access to the skin’s immune cells. The use of toxin adjuvants such as cholera or heat-labile toxins was demonstrated to enhance the immunogenicity of vaccine antigens, probably due to their stimulatory effects on immune cells. Oleic acid or retinoic acid, known as permeation enhancers or immune modulators, were found to increase immune responses to inactivated whole-influenza viral vaccines. The further development of more effective delivery systems and nontoxic adjuvants is needed to enhance the efficacy of this approach to vaccination.

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  1. Department of Microbiology & Immunology and Emory Vaccine Center, School of Medicine, Emory University, 1510 Clifton Rd, Atlanta, GA, 30322, USA

    Ioanna Skountzou & Sang-Moo Kang

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  1. Ioanna Skountzou
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Correspondence to Ioanna Skountzou .

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Editors and Affiliations

  1. School of Medicine, Emory University, Atlanta, 30322, U.S.A.

    Richard W. Compans

  2. School of Medicine, Emory University, Clifton Road 1510, Atlanta, 30322, U.S.A.

    Walter A. Orenstein

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Skountzou, I., Kang, SM. (2009). Transcutaneous Immunization with Influenza Vaccines. In: Compans, R., Orenstein, W. (eds) Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology, vol 333. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92165-3_17

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