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Recombinant Proteins Produced in Insect Cells

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Vaccines for Pandemic Influenza

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 333))

Abstract

Both purified expressed proteins and virus-like particles generated in insect cells by recombinant baculoviruses are being explored as potential vaccines for seasonal and pandemic influenza. Clinical trials have suggested that recombinant hemagglutinin vaccines are well tolerated in healthy and elderly adults, that they induce a functional antibody response, and that they provide protection against seasonal influenza in adults. In one trial, a pandemic formulation of H5 vaccine (rH5) induced neutralizing antibody in adults at rates roughly similar to that seen with egg-derived subvirion H5N1 vaccine. Preliminary data suggest that vaccination with the rH5 can also prime for booster responses on revaccination with drifted strains of H5. Recombinant approaches may be extremely valuable in combating future pandemics and further studies of recombinant pandemic vaccines in humans are needed.

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Authors and Affiliations

  1. Infectious Diseases Division, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA

    John Treanor

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  1. John Treanor
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Correspondence to John Treanor .

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Editors and Affiliations

  1. School of Medicine, Emory University, Atlanta, 30322, U.S.A.

    Richard W. Compans

  2. School of Medicine, Emory University, Clifton Road 1510, Atlanta, 30322, U.S.A.

    Walter A. Orenstein

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© 2009 Springer-Verlag Berlin Heidelberg

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Treanor, J. (2009). Recombinant Proteins Produced in Insect Cells. In: Compans, R., Orenstein, W. (eds) Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology, vol 333. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92165-3_11

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