Abstract
Event-related studies have provided indirect evidence that Attention Deficit Hyperactivity Disorder (ADHD) children have abnormalities in signal detection and discrimination, and in information processing. Moreover, studies suggest that there exist very low frequency fluctuations modulating underlying neuronal events. This paper presents an event-related fields (ERF) study involving the analysis of magnetoencephalographic (MEG) recordings of children with ADHD and controls during selective attention and perceptual, stimuli-based tasks. A specific form of blind-source separation — space-time independent component analysis (ST-ICA) — is used to isolate the early M100 responses within the data, which are indicative of selective attention deficits. The properties of the extracted responses, namely the amplitude and latency, as well as the power spectral densities of their inter-trial variations are then analyzed. Preliminary results demonstrate the ability of ST-ICA to extract relevant components from multi-dimensional, noisy, ERF data, and reveal differences in the amplitude and latency variations of the M100 responses of the two groups.
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References
Mulas F, Capilla A, Fernández S, Etchepareborda M C, Campo P, Maestú F, Fernández A, Castellanos F X and Ortiz T (2006) Shifting-Related Brain Magnetic Activity in Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry, 59:373–379
Jonkman L, Kenemans J, Kemner C, Verbaten M and Engeland H (2004) Dipole source localization of event-related brain activity indicative of an early visual selective attention deficit in ADHD children. J Clin Neurophys, 115:1537–1549
Ozdag M, Yorbik O, Ulas U, Hamamcioglu K and Vural O (2004) Effect of methylphenidate on auditory event related potential in boys with attention deficit hyperactivity disorder. Int J Pediatr Otorhinolaryngol, 68: 1267–1272
Perchet C, Revol O, Fourneret O, Mauguiere F, Garcia-Larrea L (2001) Attention shift and anticipatory mechanisms in hyperactive children: an ERP study using Posner paradigm. Biol Psychiatry, 50:44–57
Castellanos F, Sonuga-Barke E, Scheres A, Di Martino A, Hyde C and Walters J (2005) Varieties of Attention-Deficit/Hyperactivity Disorder-Related Intra-Individual Variability. Biol Psychiatry, 57:1416–1423
Makeig S, Jung T-P, Bell A J, Ghahremani D and Sejnowski J (1997) Blind separation of auditory event-related brain responses into independent components. Neurobiology, 94:10979–10984
Davies M E and James C J (2007) Source separation using single channel ICA. Signal Processing, 87:1819–1832
James C J (2008) Contrasting spatial, temporal and spatio-temporal ICA applied to ictal EEG recordings, Proc. 30th IEEE EMBS Annual Int Conf, Vancouver, Canada
Hyvärinen A, Karhunen J and Oja E (2001) Independent Component Analysis. Wiley, New York
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Demanuele, C., James, C., Capilla, A., Sonuga-Barke, E.J.S. (2009). Extracting Event-Related Field Components Through Space-Time ICA: a Study of MEG Recordings from Children with ADHD and Controls. In: Vander Sloten, J., Verdonck, P., Nyssen, M., Haueisen, J. (eds) 4th European Conference of the International Federation for Medical and Biological Engineering. IFMBE Proceedings, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_11
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DOI: https://doi.org/10.1007/978-3-540-89208-3_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-89207-6
Online ISBN: 978-3-540-89208-3
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