Ultrasound characterization of aggregated red blood cells: towards in vivo application
Ultrasonic backscattered signals from blood contain frequency-dependent information that can be used to obtain quantitative parameters reflecting the aggregation state of red blood cells (RBCs). The difficulty to use this frequencydependent information in vivo is due to the attenuation caused by intervening tissue layers that distorts the spectral content of backscattering properties from blood microstructures. We propose an optimizationmethod to simultaneously estimate tissue attenuation and blood structure factor. In an in vitro experiment, we obtained satisfactory estimates with relative errors below 25% for attenuations between 0.115 and 0.412 dB/cm/MHz and D < 10 (D the aggregate diameter expressed in number of RBCs).
KeywordsShear Rate Packing Factor Total Attenuation Aggregate Diameter Scatterer Size
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