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Neuroblastom und andere Nebennierentumoren

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Kinderchirurgie

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Das Neuroblastom ist der häufigste extrakranielle solide Tumor des Kindesalters. Der Tumor geht von embryonalen sympathischen Neuroblasten des Grenzstranges, der Nebenniere oder den Sympathikusganglien des vegetativen Nervensystems aus. Die Morphologie entspricht den Entwicklungsstadien der sympathischen Ganglien. Etwa 2,6% sind zervikal, 14,7% thorakal 79% im Abdomen (51% in der Nebenniere und 28% extraadrenal), der Rest im Becken oder unentdeckt. Der Tumor ist heterogen mit einem weiten Spektrum in seiner klinischen Manifestation und in seinem biologischen Verhalten. Der Verlauf der Erkrankung kann sehr variabel sein: im Säuglingsalter können Spontanremissionen sogar bei metastasierten Erkrankungen auftreten, während das 5-Jahres-Überleben älterer Kinder mit metastaslerter Erkrankung nur bei etwa 40% liegt. Wichtige prognostische Faktoren sind das Alter des Patienten bei Diagnosestellung, das Erkrankungsstadium sowie molekulargenetische Marker.

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Authors and Affiliations

  1. Universitätsklinik für Chirurgie, Allgemeines Krankenhaus der Stadt Wien, Währinger Gürtel 18-20, A-1090, Wien

    Univ.-Prof. Dr. med. E. Horcher

  2. St. Anna-Kinderspital, Kinderspitalgasse 6, A-1090, Wien

    Dozentin Dr. med. R. Ladenstein

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  1. Univ.-Prof. Dr. med. E. Horcher
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  2. Dozentin Dr. med. R. Ladenstein
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© 2009 Springer Medizin Verlag Heidelberg

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Horcher, E., Ladenstein, R. (2009). Neuroblastom und andere Nebennierentumoren. In: Kinderchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89032-4_43

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  • DOI: https://doi.org/10.1007/978-3-540-89032-4_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89031-7

  • Online ISBN: 978-3-540-89032-4

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