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Drug Addiction

  • Zuzana Justinova
  • Leigh V. Panlilio
  • Steven R. GoldbergEmail author
Chapter
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 1)

Abstract

Many drugs of abuse, including cannabinoids, opioids, alcohol and nicotine, can alter the levels of endocannabinoids in the brain. Recent studies show that release of endocannabinoids in the ventral tegmental area can modulate the reward-related effects of dopamine and might therefore be an important neurobiological mechanism underlying drug addiction. There is strong evidence that the endocannabinoid system is involved in drug-seeking behavior (especially behavior that is reinforced by drug-related cues), as well as in the mechanisms that underlie relapse to drug use. The cannabinoid CB1 antagonist/inverse agonist rimonabant has been shown to reduce the behavioral effects of stimuli associated with drugs of abuse, including nicotine, alcohol, cocaine, and marijuana. Thus, the endocannabinoid system represents a promising target for development of new treatments for drug addiction.

Keywords

Drug addiction Cannabinoids Endocannabinoids Self-administration Relapse Reward THC 

Abbreviations

2-AG

2-Arachidonoylglycerol

AEA

Anandamide

VTA

ventral tegmental area

DAT

dopamine transporter

THC

delta-9-tetrahydrocannabinol

FAAH

fatty acid amide hydrolase

Notes

Acknowledgements

The preparation of this manuscript was supported in part by the Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services and Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Zuzana Justinova
    • 1
  • Leigh V. Panlilio
    • 1
  • Steven R. Goldberg
    • 1
    Email author
  1. 1.Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research ProgramNational Institute on Drug Abuse, National Institutes of HealthBaltimoreUSA

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