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DNA Cages with Icosahedral Symmetry in Bionanotechnology

  • Nataša JonoskaEmail author
  • Anne Taormina
  • Reidun Twarock
Chapter
Part of the Natural Computing Series book series (NCS)

Abstract

Blueprints for polyhedral cages with icosahedral symmetry made of circular DNA molecules are provided. The basic rule is that every edge of the cage is met twice in opposite directions by the DNA strand(s), and vertex junctions are realized by a set of admissible junction types. As nanocontainers for cargo storage and delivery, the icosidodecahedral cages are of special interest because they have the largest volume per surface ratio of all cages discussed here.

Keywords

Icosahedral Symmetry Dashed Blue Line Double Helical Structure Separate Strand Pentagonal Face 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Chen JH, Seeman NC (1991) Synthesis from DNA of a molecule with the connectivity of a cube. Nature 350:631–633 CrossRefGoogle Scholar
  2. 2.
    Goodman RP, Schaap IAT, Tardin CF, Erben CM, Berry RM, Schmidt CF, Turberfield AJ (2005) Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science 310:1661–1665 CrossRefGoogle Scholar
  3. 3.
    Shih WM, Quispe JD, Joyce GF (2004) A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature 427:618–621 CrossRefGoogle Scholar
  4. 4.
    Zhang Y, Seeman NC (1994) The construction of a DNA truncated octahedron. J Am Chem Soc 116:1661–1669 CrossRefGoogle Scholar
  5. 5.
    Destito G, Singh P, Koudelka KJ, Manchester M (2007) Assembling viral nanoparticles for vascular imaging and tumor-specific targeting. In: Foundations of nanoscience, self-assembled architectures and devices, proceedings of FNANO07, pp 2–4 Google Scholar
  6. 6.
    Grayson NE, Taormina A, Twarock R (2009) DNA duplex cage structures with icosahedral symmetry. J Theor Comp Sci 410(15):1440–1447 zbMATHCrossRefMathSciNetGoogle Scholar
  7. 7.
    Jonoska N, Twarock R (2008) Blueprints for dodecahedral DNA cages. J Phys A 41:304043–304057 CrossRefMathSciNetGoogle Scholar
  8. 8.
    Jonoska N, Saito M (2002) Boundary components of thickened graphs. In: Jonoska N, Seeman NC (eds) DNA7. Lecture notes in computer science, vol 2340. Springer, Heidelberg, p 70 Google Scholar
  9. 9.
    Greenberg MJ, Harper JR (1981) Algebraic topology. Benjamin/Cummings, Redwood City zbMATHGoogle Scholar
  10. 10.
    Ho PS, Eichman BF (2001) The crystal structures of DNA holliday junctions. Curr Opin Struct Biol 11:302–308 CrossRefGoogle Scholar
  11. 11.
    Tang L, Johnson KN, Ball LA, Lin T, Yeager M, Johnson JE (2001) The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA. Nat Struct Biol 8:77–83 CrossRefGoogle Scholar
  12. 12.
    van den Worm SHE, Koning RE, Warmenhoven HJ, Koerten HK, van Duin J (2006) Cryo electron microscopy reconstructions of the Leviviridae unveil the densest icosahedral RNA packing possible. J Mol Biol 363:858–865 CrossRefGoogle Scholar
  13. 13.
    Toropova K, Basnak G, Twarock R, Stockley PG, Ranson NA (2008) The three-dimensional structure of genomic RNA in bacteriophage MS2: implications for assembly. J Mol Biol 375:824–836 CrossRefGoogle Scholar
  14. 14.
    Rudnick J, Bruinsma R (2005) Icosahedral packing of RNA viral genomes. Phys Rev Lett 94:038101–038104 CrossRefGoogle Scholar
  15. 15.
    Sa-Ardyen P, Jonoska N, Seeman NC (2004) Self-assembly of irregular graphs whose edges are DNA helix axes. J Am Chem Soc 126:6648–6657 CrossRefGoogle Scholar
  16. 16.
    Sa-Ardyen P, Jonoska N, Seeman NC (2003) Self-assembling DNA graphs. Nat Comput 2:427–438 zbMATHCrossRefMathSciNetGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Nataša Jonoska
    • 1
    Email author
  • Anne Taormina
    • 2
  • Reidun Twarock
    • 3
  1. 1.Department of MathematicsUniversity of South FloridaTampaUSA
  2. 2.Department of Mathematical SciencesUniversity of DurhamDurhamUK
  3. 3.Department of Mathematics and Department of BiologyUniversity of YorkYorkUK

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