A New Mathematical Model for the Heat Shock Response

  • Ion PetreEmail author
  • Andrzej Mizera
  • Claire L. Hyder
  • Andrey Mikhailov
  • John E. Eriksson
  • Lea Sistonen
  • Ralph-Johan Back
Part of the Natural Computing Series book series (NCS)


We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.


Heat Shock Heat Shock Protein Gene Regulatory Network Heat Shock Response Heat Shock Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Ion Petre
    • 1
    Email author
  • Andrzej Mizera
    • 1
  • Claire L. Hyder
    • 2
    • 3
  • Andrey Mikhailov
    • 2
    • 3
  • John E. Eriksson
    • 2
    • 3
  • Lea Sistonen
    • 2
    • 3
  • Ralph-Johan Back
    • 1
  1. 1.Department of Information TechnologiesÅbo Akademi UniversityTurkuFinland
  2. 2.Turku Centre for BiotechnologyTurkuFinland
  3. 3.Department of BiochemistryÅbo Akademi UniversityTurkuFinland

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