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Biological Functions of Trehalose as a Substitute for Water

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Water and Biomolecules

Part of the book series: Biological and Medical Physics, Biomedical ((BIOMEDICAL))

Abstract

A disaccharide, α, α-trehalose, acts as a substitute for water in biological systems. Such a function comes from the unique hydration and solid-state properties of this sugar, which ultimately originate in the presence of the α, α-1,1-glycosidic linkage. A recent study on the anhydrobiosis of Polypedilum vanderplanki, an insect that survives desiccation, brought about a significant advance in our understanding of the functional mechanism of trehalose in vivo.

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References

  1. J.H. Crowe, F.A. Hoekstra, L. Crowe, Annu. Rev. Physiol. 54, 579 (1992)

    Article  PubMed  CAS  Google Scholar 

  2. J.S. Clegg, Comp. Biochem. Physiol. B 128, 613 (2001)

    Article  PubMed  CAS  Google Scholar 

  3. M. Watanabe, T. Kikawada, N. Minagawa, F. Yukuhiro, T. Okuda, J. Exp. Biol. 205, 2799 (2002)

    PubMed  CAS  Google Scholar 

  4. R.A. Ring, H.V. Danks, Cryo Lett. 19, 275 (1998)

    CAS  Google Scholar 

  5. P.O. Montiel, Cryo Lett. 21, 83 (2000)

    Google Scholar 

  6. A.V. Laere, FEMS Microbiol. Rev. 63, 201 (1988)

    Google Scholar 

  7. N. Benaroudj, D.H. Lee, L.A. Goldberg, J. Biol. Chem. 276, 24261 (2001)

    Article  PubMed  CAS  Google Scholar 

  8. K. Oku, M. Kurose, M. Kubota, S. Fukuda, M. Kurimoto, Y. Tujisaka, M. Sakurai, Nippon Shokuhin Kagaku Kougaku Kaishi (in Japanese) 50, 133 (2003)

    CAS  Google Scholar 

  9. R.S. Herderio, M.D. Pereira, A.D. Panek, E.C.A. Eleutherio, Biochem. Biophys. Acta 1760, 340 (2006)

    Google Scholar 

  10. M. Sola-Penna, J.R. Meyer-Fernandes, Arch. Biochem. Biophys. 360, 10 (1998)

    Article  PubMed  CAS  Google Scholar 

  11. M-O. Portmann, G. Birch, J. Sci. Food Agric. 69, 275 (1995)

    Article  CAS  Google Scholar 

  12. P.K. Banipal, T.S. Banipal, B.S. Lark, J.C. Ahluwalia, J. Chem. Soc. Faraday Trans. 93, 81 (1997)

    Article  CAS  Google Scholar 

  13. S.A. Galema, H. Hϕiland, J. Phys. Chem. 95, 5321 (1991)

    Article  CAS  Google Scholar 

  14. S. Magazu, V. Villiari, P. Migliardo, G. Maisano, M.T.F. Telling, J. Phys. Chem. B 105, 1851 (2001)

    Article  CAS  Google Scholar 

  15. H. Kawai, M. Sakurai, Y. Inoue, R. Chûjó, S. Kobayashi, Cryobiology 29, 599 (1992)

    Article  PubMed  CAS  Google Scholar 

  16. M. Heyden, E. Bründermann, U. Heugen, G. Niehues, D.M. Leitner, M. Havenith, J. Am. Chem. Soc. 130, 5773 (2008)

    Article  PubMed  CAS  Google Scholar 

  17. H. Uedaira, M. Ikura, H. Uedaira, Bull. Chem. Soc. Jpn. 62, 1 (1989)

    Article  CAS  Google Scholar 

  18. C. Branca, S. Magazú, G. Maisano, P. Migliardo, J. Chem. Phys. 111, 281 (1999)

    Article  CAS  Google Scholar 

  19. C. Branca, S. Magazú, G. Maisano, S.M. Bennington, B. Fåk, J. Phys. Chem. 107, 1444 (2003)

    CAS  Google Scholar 

  20. M.K. Dowd, P.J. Reilly, A.D. French, J. Comp. Chem. 13, 102 (1992)

    Article  CAS  Google Scholar 

  21. A.D. French, G.P. Johnson, A-M. Keltere, M.K. Dowd, C.J. Cramer, J. Phys. Chem. A 106, 4988 (2002)

    Article  CAS  Google Scholar 

  22. M. Sakurai, M. Murata, Y. Inoue, A. Hino, S. Kobayashi, Bull. Chem. Soc. Jpn. 70, 847 (1997)

    Article  CAS  Google Scholar 

  23. Q. Liu, R.K. Schmit, B. Teo, P.A. Karplus, J.W. Brady, J. Am. Chem. Soc. 119, 7851 (1997)

    Article  CAS  Google Scholar 

  24. G. Bonanno, R. Noto, S.L. Fornili, J. Chem. Soc. Faraday Trans. 94, 2755 (1998)

    Article  CAS  Google Scholar 

  25. P.B. Conrad, J.J. de Pablo, J. Phys. Chem. A 103, 4049 (1999)

    Article  CAS  Google Scholar 

  26. S.B. Engelsen, S. Pérez, J. Phys. Chem. B 104, 9301 (2000)

    Article  CAS  Google Scholar 

  27. A. Lerbret, P. Bordat, F. Affouard, Y. Guinet, A. Hédoux, L. Paccou, D. Prévost, M. Descamps, Carbohydr. Res. 340, 881 (2005)

    Article  PubMed  CAS  Google Scholar 

  28. A. Lerbret, P. Bordat, F. Affouard, M. Descamps, F. Migliardo, J. Phys. Chem. B. 109, 11046 (2005)

    Article  PubMed  CAS  Google Scholar 

  29. Y. Choi, K.W. Cho, K. Jeong, S. Jung, Carbohydr. Res. 341, 1020 (2006)

    Article  PubMed  CAS  Google Scholar 

  30. K. Akao, Y. Okubo, T. Ikeda, Y. Inoue, M. Sakurai, Chem. Lett. 8, 759 (1998)

    Article  Google Scholar 

  31. T. Furuki, R. Abe, H. Kawaji, T. Atake, M. Sakurai, J. Chem. Thermodyn. 38, 1612 (2006)

    Article  CAS  Google Scholar 

  32. G.M. brown, D.C. Rohrer, B. Berking, C.A. Beevers, R.G. Gould, R. Simpson, Acta Crystallogr. B 28, 3145 (1972)

    Article  CAS  Google Scholar 

  33. T. Taga, M. Senma, K. Osaki, Acta Crystallogr. B 28, 3258 (1972)

    Article  CAS  Google Scholar 

  34. G.A. Jeffrey, R. Nanni, Carbohydr. Res. 137, 21 (1985)

    Article  PubMed  CAS  Google Scholar 

  35. K. Akao, Y. Okubo, N. Asakawa, Y. Inoue, M. Sakurai, Carbohydr. Res. 334, 233 (2001)

    Article  PubMed  CAS  Google Scholar 

  36. H. Nagase, T. Endo, H. Ueda, M. Nakagaki, Carbohydr. Res. 337, 167 (2002)

    Article  PubMed  CAS  Google Scholar 

  37. F. Sussich, R. Urbani, A. Cesàro, F. Princivalle, S. Brückner, Carbohydr. Lett. 2, 403 (1997)

    CAS  Google Scholar 

  38. F. Sussich, R.Urbani, F. Princivalle, A. Cesàro, J. Am. Chem. Soc. 120, 7893(1998)

    Article  CAS  Google Scholar 

  39. F. Sussich, C. Skopec, J. Brady, A. Cesàro, Carbohydr. Res. 334, 165 (2001)

    Article  PubMed  CAS  Google Scholar 

  40. H. Nagase, T. Endo, H. Ueda, T. Nagai, STP Pharm. Sci. 13, 269 (2003)

    CAS  Google Scholar 

  41. A.M. Gil, P.S. Belton, V. Felix, Spectrochim. Acta 52, 1649 (1996)

    Article  Google Scholar 

  42. K. Akao, Y. Okubo, Y. Inoue, M. Sakurai, Carbohydr. Res. 337, 1729 (2002)

    Article  PubMed  CAS  Google Scholar 

  43. H. Nagase, N. Ogawa, T. Endo, M. Shiro, H. Ueda, M. Sakurai, J. Phys. Chem. B 112, 9105 (2008)

    Article  PubMed  CAS  Google Scholar 

  44. F. Sussich, A. Cesaro, J. Therm. Anal. Calorim. 62, 757 (2000)

    Article  CAS  Google Scholar 

  45. J.F. Willart, A. De Gusseme, S. Hemon, M. Descamps, F. Leveiller, A. Rameau, J. Phys. Chem. B 106, 3365 (2002)

    Article  CAS  Google Scholar 

  46. L.S. Taylor, P. York, J. Pharm. Sci. 87, 347 (1998)

    Article  PubMed  CAS  Google Scholar 

  47. L.S. Taylor, A.C. Williams, P. York, Pharm. Res. 15, 1207 (1998)

    Article  PubMed  CAS  Google Scholar 

  48. T. Furuki, A. Kishi, M. Sakurai, Carbohydr. Res. 340, 429 (2005)

    Article  PubMed  CAS  Google Scholar 

  49. T. Furuki, R. Abe, H. Kawaji, T. Atake, M. Sakurai, J. Therm. Anal. Calorim. 91, 561–567 (2008)

    Article  CAS  Google Scholar 

  50. D. Kilburn, S. Townrow, V. Meunier, R. Richardson, A. Alam, J. Ubbink, Nat. Mater. 5, 632 (2006)

    Article  CAS  Google Scholar 

  51. L.M. Crowe, D.S. Reid, J.H. Crowe, Biophys. J. 71, 2087 (1996)

    Article  PubMed  CAS  Google Scholar 

  52. D.P. Milller, J.J. de Pablo, J. Phys. Chem. B 104, 8876 (2000)

    Article  CAS  Google Scholar 

  53. T. Chen, A. Fowler, M. Toner, Cryobiology 40, 277 (2000)

    Article  PubMed  CAS  Google Scholar 

  54. R. Surama, A. Pyne, R. Suryanarayanan, Pharm. Res. 21, 867 (2004)

    Article  Google Scholar 

  55. K. Kawai, T. Hagiwara, R. Takai, T. Suzuki, Pharm. Res. 22, 490 (2005)

    Article  PubMed  CAS  Google Scholar 

  56. J.L. Green, C.A. Angell, J. Phys. Chem. 93, 2880 (1989)

    Article  CAS  Google Scholar 

  57. K. Oku, M. Kubota, S. Fukuda, M. Kurimoto, Y. Tujisaka, M. Sakurai, Cryobiol. Cryotechnol. 50, 97 (2004)

    Google Scholar 

  58. B.J. Aldous, A.D. Affret, F. Franks, Cryo Lett. 16, 181 (1996)

    Google Scholar 

  59. J.H. Crowe, J.F. Carpenter, L.M. Crowe, Annu. Rev. Physiol. 60, 73 (1998)

    Article  PubMed  CAS  Google Scholar 

  60. J.H. Crowe, in Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks, ed. by P. Csermely, L. Vígh (Landes Bioscience and Springer, New York, 2007), Chapter 13

    Google Scholar 

  61. P.S. Belton, A.H. Gil, Biopolymers 34, 957 (1994)

    Article  PubMed  CAS  Google Scholar 

  62. G. Cottone, G. Gicotti, L. Gordone, J. Cell. Phys. 117, 9862 (2002)

    CAS  Google Scholar 

  63. R.D. Lins, C.S. Pereira, P.H. Hünenberger, Proteins 55, 177 (2004)

    Article  PubMed  CAS  Google Scholar 

  64. A.K. Sum, R. Faller, J.J. de Pablo, Biophys. J. 85, 2830 (2003)

    Article  PubMed  CAS  Google Scholar 

  65. M.A. Villarreal, S.B. Díaz, E.A. Disalvo, G.G. Montich, Langmuir 20, 7844 (2004)

    Article  PubMed  CAS  Google Scholar 

  66. C.S. Pereira, R.D. Lins, I. Chandrasekhar, L.C.G. Freitas, P.H. Hünenberger, Biophys. J. 86, 2273 (2004)

    Article  PubMed  CAS  Google Scholar 

  67. A. Skibinsky, R.M. Venable, R.W. Pastor, Biophys. J. 89, 4111 (2005)

    Article  PubMed  CAS  Google Scholar 

  68. C.S. Pereira, P.P.H. Hünenberger, J. Phys. Chem. B 110, 15572 (2006)

    Article  PubMed  CAS  Google Scholar 

  69. L. Lerbret, F. Affouard, P. Bordat, A. Hédoux, Y. Guinet, M. Descamps, Chem. Phys. 345, 267 (2008)

    Article  CAS  Google Scholar 

  70. F. Albertorio, V.A. Chapa, X. Chen, A.J. Diaz, P.S. Cremer, J. Am. Chem. Soc. 129, 10567 (2007)

    Article  PubMed  CAS  Google Scholar 

  71. F. Sano, N. Asakawa, Y. Inoue, M. Sakurai, Cryobiology 39, 80 (1999)

    Article  PubMed  CAS  Google Scholar 

  72. M. Sakurai, H. Kawai, Y. Inoue, A. Hino, S. Kobayashi, Bull. Chem. Soc. Jpn. 68, 3621 (1995)

    Article  CAS  Google Scholar 

  73. M. Sakurai, T. Furuki, K. Akao, D. Tanaka, Y. Nakahara, T. Kikawada, M. Watanabe, T. Okuda, Proc. Natl. Acad. Sci. USA 105, 5093 (2008)

    Article  PubMed  CAS  Google Scholar 

  74. H.E. Hinton, J. Insect Physiol. 5, 286 (1960)

    Article  Google Scholar 

  75. H.E. Hinton, Nature 188, 336 (1960)

    Article  Google Scholar 

  76. S. Adams, Antenna 8, 58 (1985)

    Google Scholar 

  77. M. Watanabe, M. Kikawada, T. Okuda, J. Exp. Biol. 206, 2281 (2003)

    Article  PubMed  CAS  Google Scholar 

  78. B. Zhu, T. Furuki, T. Okuda, M. Sakurai, J. Phys. Chem. B 111, 5542 (2007)

    Article  PubMed  CAS  Google Scholar 

  79. W.Q. Sun, A. Leopold, Comp. Biochem. Physiol. A 117, 327 (1997)

    Article  Google Scholar 

  80. J. Buitink, O. Leprince, Cryobiology 48, 215 (2004)

    Article  PubMed  CAS  Google Scholar 

  81. A. Tunnacliffe, M.J. Wise, Naturwissenshafen 114, 741 (2007)

    Google Scholar 

  82. W.F. Wolkers, S. McCready, W. Brandt, G.G. Lindsey, F.A. Hoekstra, Biochim. Biophys. Acta 1544, 196 (2001)

    PubMed  CAS  Google Scholar 

  83. T. Kikawada, Y. Nakahara, Y. Kanamori, K. Iwata, M. Watanabe, B. McGee, A. Tunnacliffe, T. Okuda, Biochem. Biophys. Res. Commun. 348, 56 (2006)

    Article  PubMed  CAS  Google Scholar 

  84. T.-Y. Lin, S.N. Timasheff, Protein Sci. 5, 372 (1996)

    Article  PubMed  CAS  Google Scholar 

  85. G. Xie, S.N. Timasheff, Biophys. Chem. 64, 25 (1997)

    Article  PubMed  CAS  Google Scholar 

  86. J.K. Kaushik, R. Bhat, Proc. Natl. Acad. Sci. USA 278, 26458 (2003)

    CAS  Google Scholar 

  87. T. Nishiwaki, M. Sakurai, Y. Inoue, R. Chujo, S. Kobayashi, Chem. Lett. 19, 1841 (1990)

    Article  Google Scholar 

  88. M. Tanaka, Y. Machida, S. Niu, T. Ikeda, N.R. Jana, H. Doi, M. Kurosawa, M. Nekooki, N. Nukina, Nat. Med. 10, 148 (2004)

    Article  PubMed  CAS  Google Scholar 

  89. R. Liu, H. Barkhordarian, S. Emadi, C.B. Park, M.R. Sierks, Neurobiol. Dis. 20, 74 (2005)

    Article  PubMed  CAS  Google Scholar 

  90. M.A. Singer, S. Lindquist, Mol. Cell 1, 639 (1998)

    Article  PubMed  CAS  Google Scholar 

  91. K. Oku, H. Watanabe, M. Kubota, S. Fukuda, M. Kurimoto, Y. Tsujisaka, M. Komori, Y. Inoue, M. Sakurai, J. Am. Chem. Soc. 125, 12739 (2003)

    Article  PubMed  CAS  Google Scholar 

  92. K. Oku, M. Kurose, M. Kubota, S. Fukuda, M. Kurimoto, Y. Tujisaka, A. Okabe, M. Sakurai, J. Phys. Chem. B 109, 3032 (2005)

    Article  PubMed  CAS  Google Scholar 

  93. A. Okabe, K. Oku, S. Fukuda, T. Furuki, M. Sakurai, Cryobiol. Cryotechnol. 53, 111 (2007)

    Google Scholar 

  94. G. Brumfiel, Nature 428, 14 (2004)

    Article  PubMed  CAS  Google Scholar 

  95. N. Guo, I. Puhlev, D.R. Brown, J. Mansbridge, F. Levine, Nat. Biotechnol. 18, 168 (2000)

    Article  PubMed  CAS  Google Scholar 

  96. A. Eroglu, M.J. Russo, R. Bieganski, A. Fowler, S. Cheley, H. Bayley, M. Toner, Nat. Biotechnol. 18, 163 (2000)

    Article  PubMed  CAS  Google Scholar 

  97. T. Kikawada, A. Saito, Y. Kanamori, Y. Nakahara, K. Iwata, D. Tanaka, M. Watanabe, T. Okuda, Proc. Natl. Acad. Sci. USA 104, 11585 (2007)

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Biological Resources and Informatics, Tokyo Institute of Technology, B-62 Nagatsuta-cho, Midori-ku, Yokohama, 226-8501, Japan

    M. Sakurai

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  1. M. Sakurai
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Editors and Affiliations

  1. Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan

    Kunihiro Kuwajima

  2. Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yuji Goto

  3. Institute for Molecular Science Department for Theoretical and Computational Molecular Science, National Institutes of Natural Sciences, 38 Nishigo-Naka, Myodaiji, Okazaki, 444-8585, Japan

    Fumio Hirata

  4. Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-6 Takayama, Ikoma, Nara, 630-0192, Japan

    Mikio Kataoka

  5. Graduate School of Science, Department of Chemistry, Kyoto University, Oiwakecho, Kitashirakawa, Kyoto, 606-8502, Japan

    Masahide Terazima

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Sakurai, M. (2009). Biological Functions of Trehalose as a Substitute for Water. In: Kuwajima, K., Goto, Y., Hirata, F., Kataoka, M., Terazima, M. (eds) Water and Biomolecules. Biological and Medical Physics, Biomedical . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88787-4_12

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