Gangliogliomas and gangliocytomas belong to a family of rare, slow-growing, neuronal tumors. Courville fi rst introduced the term “ganglioglioma” in 1930 to describe the mixed neuronal and glial elements typically seen in this tumor (Courville 1930). Although there is a pathologic difference between ganglioglioma and gangliocytoma, the natural history and biology of these two subtypes appear to be the same.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Anderson RC, Elder JB, Parsa AT, Issacson SR, Sisti MB (2001) Radiosurgery for the treatment of recurrent central neuro-cytomas. Neurosurgery 48:1231–1237; discussion 1237–1238
Armstrong DD (1993) The neuropathology of temporal lobe epilepsy. Journal of Neuropathology and Experimental Neurology 52:433–443
Ashkan K, Casey AT, D'Arrigo C, Harkness WF, Thomas DG (2000) Benign central neurocytoma. Cancer 89:1111–1120
Baussard B, Di Rocco F, Garnett MR, Boddaert N, Lellouch-Tubiana A, Grill J, Puget S, Roujeau T, Zerah M, Sainte-Rose C (2007) Pediatric infratentorial gangliogliomas: a retrospective series. Journal of Neurosurgery 107:286–291
Benifla M, Otsubo H, Ochi A, Weiss SK, Donner EJ, Shroff M, Chuang S, Hawkins C, Drake JM, Elliott I, Smith ML, Snead OC III, Rutka JT (2006) Temporal lobe surgery for intractable epilepsy in children: an analysis of outcomes in 126 children. Neurosurgery 59:1203–1213; discussion 1213–1204
Bertalanffy A, Roessler K, Koperek O, Gelpi E, Prayer D, Knosp E (2005) Recurrent central neurocytomas. Cancer 104:135–142
Blumcke I, Lobach M, Wolf HK, Wiestler OD (1999) Evidence for developmental precursor lesions in epilepsy-associated glioneuronal tumors. Microscopy Research and Technique 46:53–58
Brandes AA, Amista P, Gardiman M, Volpin L, Danieli D, Gug-lielmi B, Carollo C, Pinna G, Turazzi S, Monfardini S (2000) Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer 88:169–174
Buxton N, Ho KJ, Macarthur D, Vloeberghs M, Punt J, Robertson I (2001) Neuroendoscopic third ventriculostomy for hydrocephalus in adults: report of a single unit's experience with 63 cases. Surgical Neurology 55:74–78
Cervera-Pierot P, Varlet P, Chodkiewicz JP, Daumas-Duport C (1997) Dysembryoplastic neuroepithelial tumors located in the caudate nucleus area: report of four cases. Neurosur-gery 40:1065–1069; discussion 1069–1070
Chan CH, Bittar RG, Davis GA, Kalnins RM, Fabinyi GC (2006) Long-term seizure outcome following surgery for dysem-bryoplastic neuroepithelial tumor. Journal of Neurosur-gery 104:62–69
Chang KH, Han MH, Kim DG, Chi JG, Suh DC, Kim SJ, Cha SH, Han MC (1993) MR appearance of central neurocytoma. Acta Radiologica 34:520–526
Chang EF, Potts MB, Keles GE, Lamborn KR, Chang SM, Bar-baro NM, Berger MS (2008) Seizure characteristics and control following resection in 332 patients with low-grade gliomas. Journal of Neurosurgery 108:227–235
Christov C, Adle-Biassette H, Le Guerinel C (1999) Recurrent central neurocytoma with marked increase in MIB-1 labelling index. British Journal of Neurosurgery 13:496–499
Cobery ST, Noren G, Friehs GM, Chougule P, Zheng Z, Epstein MH, Taylor W (2001) Gamma knife surgery for treatment of central neurocytomas. Report of four cases. Journal of Neurosurgery 94:327–330
Courville CB (1930) Ganglioglioma: tumor of the central nervous system. Review of the literature and report of two cases. Archives of Neurology and Psychiatry 24:438–491
Daumas-Duport C (1993) Dysembryoplastic neuroepithelial tumours. Brain Pathology 3:283–295
Daumas-Duport C, Scheithauer BW, Chodkiewicz J P, Laws ER Jr, Vedrenne C (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases. Neurosurgery 23:545–556
Dodds D, Nonis J, Mehta M, Rampling R (1997) Central neu-rocytoma: a clinical study of response to chemotherapy. Journal of Neurooncology 34:279–283
Dorne HL, O'Gorman AM, Melanson D (1986) Computed tomography of intracranial gangliogliomas. AJNR. American Journal of Neuroradiology 7:281–285
Elek G, Slowik F, Eross L, Toth S, Szabo Z, Balint K (1999) Central neurocytoma with malignant course. Neuronal and glial differentiation and craniospinal dissemination. Pathology Oncology Research 5:155–159
Eng DY, DeMonte F, Ginsberg L, Fuller GN, Jaeckle K (1997) Craniospinal dissemination of central neurocytoma. Report of two cases. Journal of Neurosurgery 86:547–552
Faria C, Miguens J, Antunes JL, Barroso C, Pimentel J, Martins Mdo C, Moura-Nunes V, Roque L (2008) Genetic alterations in a papillary glioneuronal tumor. Journal of Neurosurgery Pediatrics 1:99–102
Fernandez C, Girard N, Paz Paredes A, Bouvier-Labit C, Lena G, Figarella-Branger D (2003) The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases. AJNR. American Journal of Neuroradiology 24:829–834
Giulioni M, Galassi E, Zucchelli M, Volpi L (2005) Seizure outcome of lesionectomy in glioneuronal tumors associated with epilepsy in children. Journal of Neurosurgery 102:288–293
Giulioni M, Gardella E, Rubboli G, Roncaroli F, Zucchelli M, Bernardi B, Tassinari CA, Calbucci F (2006) Lesionec-tomy in epileptogenic gangliogliomas: seizure outcome and surgical results. Journal of Clinical Neuroscience 13:529–535
Goergen SK, Gonzales MF, McLean CA (1992) Interventricular neurocytoma: radiologic features and review of the literature. Radiology 182:787–792
Haddad SF, Moore SA, Menezes AH, VanGilder JC (1992) Gan-glioglioma: 13 years of experience. Neurosurgery 31:171–178
Hakim R, Loeffler JS, Anthony DC, Black PM (1997) Ganglio-gliomas in adults. Cancer 79:127–131
Hall WA, Yunis EJ, Albright AL (1986) Anaplastic ganglio-glioma in an infant: case report and review of the literature. Neurosurgery 19:1016–1020
Hamburger C, Buttner A, Weis S (1997) Ganglioglioma of the spinal cord: report of two rare cases and review of the literature. Neurosurgery 41:1410–1415; discussion 1415–1416
Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P (1993) Central neurocytoma: a synopsis of clinical and histological features. Brain Pathology 3:297–306
Hirose T, Scheithauer BW, Lopes MB, VandenBerg SR (1994) Dysembryoplastic neuroeptihelial tumor (DNT): an immu-nohistochemical and ultrastructural study. Journal of Neu-ropathology and Experimental Neurology 53:184–195
Hirose T, Scheithauer BW, Lopes MB, Gerber HA, Altermatt HJ, VandenBerg SR (1997) Ganglioglioma: an ultrastructural and immunohistochemical study. Cancer 79:989–1003
Jallo GI, Freed D, Epstein FJ (2004) Spinal cord gangliogliomas: a review of 56 patients. Journal of Neurooncology 68:71–77
Johannsson JH, Rekate HL, Roessmann U (1981) Ganglio-gliomas: pathological and clinical correlation. Journal of Neurosurgery 54:58–63
Johnson JH Jr, Hariharan S, Berman J, Sutton LN, Rorke LB, Molloy P, Phillips PC (1997) Clinical outcome of pediatric gangliogliomas: ninety-nine cases over 20 years. Pediatric Neurosurgery 27:203–207
Kalyan-Raman U P, Olivero WC (1987) Ganglioglioma: a correlative clinicopathological and radiological study of ten surgically treated cases with follow-up. Neurosurgery 20:428–433
Khajavi K, Comair YG, Prayson RA, Wyllie E, Palmer J, Estes ML, Hahn JF (1995) Childhood ganglioglioma and medically intractable epilepsy. A clinicopathological study of 15 patients and a review of the literature. Pediatric Neurosur-gery 22:181–188
Kim DG, Paek SH, Kim IH, Chi JG, Jung HW, Han DH, Choi KS, Cho BK (1997) Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 79:1995–2002
Kim CY, Paek SH, Jeong SS, Chung HT, Han JH, Park CK, Jung HW, Kim DG (2007) Gamma knife radiosurgery for central neurocytoma: primary and secondary treatment. Cancer 110:2276–2284
Koeller KK, Dillon WP (1992) Dysembryoplastic neuroepithe-lial tumors: MR appearance. AJNR. American Journal of Neuroradiology 13:1319–1325
Kuchelmeister K, Demirel T, Schlorer E, Bergmann M, Gullotta F (1995) Dysembryoplastic neuroepithelial tumour of the cerebellum. Acta Neuropathologica 89:385–390
Kuroiwa T, Bergey GK, Rothman MI, Zoarski GH, Wolf A, Zagardo MT, Kristt DA, Hudson LP, Krumholz A, Barry E et al (1995) Radiologic appearance of the dysembryoplastic neuroepithelial tumor. Radiology 197:233–238
Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC (1993) Central nervous system gangliogliomas. Part 2: Clinical outcome. Journal of Neurosurgery 79:867–873
Leenstra JL, Rodriguez FJ, Frechette CM, Giannini C, Stafford SL, Pollock BE, Schild SE, Scheithauer BW, Jenkins RB, Buckner JC, Brown PD (2007) Central neurocytoma: management recommendations based on a 35-year experience. International Journal of Radiation Oncology, Biology, Physics 67:1145–1154
Lellouch-Tubiana A, Bourgeois M, Vekemans M, Robain O (1995) Dysembryoplastic neuroepithelial tumors in two children with neurofi bromatosis type 1. Acta Neuropatho-logica 90:319–322
Leung SY, Gwi E, Ng HK, Fung CF, Yam KY (1994) Dysembryo-plastic neuroepithelial tumor. A tumor with small neuronal cells resembling oligodendroglioma. American Journal of Surgical Pathology 18:604–614
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classifi cation of tumours of the central nervous system. Acta Neuropathologica 114:97–109
Luyken C, Blumcke I, Fimmers R, Urbach H, Elger CE, Wies-tler OD, Schramm J (2003) The spectrum of long-term epilepsy-associated tumors: long-term seizure and tumor outcome and neurosurgical aspects. Epilepsia 44:822–830
Mackenzie IR (1999) Central neurocytoma: histologic aty-pia, proliferation potential, and clinical outcome. Cancer 85:1606–1610
Maher CO, White JB, Scheithauer BW, Raffel C (2008) Recurrence of dysembryoplastic neuroepithelial tumor following resection. Pediatric Neurosurgery 44:333–336
Maiuri F, Spaziante R, De Caro ML, Cappabianca P, Gia-mundo A, Iaconetta G (1995) Central neurocytoma: clinico-pathological study of 5 cases and review of the literature. Clinical Neurology and Neurosurgery 97:219–228
Miller DC, Lang FF, Epstein FJ (1993) Central nervous system gangliogliomas. Part 1: Pathology. Journal of Neurosurgery 79:859–866
Minkin K, Klein O, Mancini J, Lena G (2008) Surgical strategies and seizure control in pediatric patients with dysembryo-plastic neuroepithelial tumors: a single-institution experience. Journal of Neurosurgery Pediatrics 1:206–210
Morris HH, Estes ML, Gilmore R, Van Ness PC, Barnett GH, Turnbull J (1993) Chronic intractable epilepsy as the only symptom of primary brain tumor. Epilepsia 34:1038–1043
Mut M, Guler-Tezel G, Lopes MB, Bilginer B, Ziyal I, Ozcan OE (2005) Challenging diagnosis: oligodendroglioma versus extra-ventricular neurocytoma. Clinical Neuropathology 24:225–229
Nakagawa K, Aoki Y, Sakata K, Sasaki Y, Matsutani M, Akanuma A (1993) Radiation therapy of well-differentiated neuro-blastoma and central neurocytoma. Cancer 72:1350–1355
Neumann E, Kalousek DK, Norman MG, Steinbok P, Cochrane DD, Goddard K (1993) Cytogenetic analysis of 109 pediat-ric central nervous system tumors. Cancer Genetics and Cytogenetics 71:40–49
Nolan MA, Sakuta R, Chuang N, Otsubo H, Rutka JT, Snead OC 3rd, Hawkins CE, Weiss SK (2004) Dysembryoplastic neu-roepithelial tumors in childhood: long-term outcome and prognostic features. Neurology 62:2270–2276
Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M, Petersen I, Holl T, Wiestler OD, Kleihues P (1993) Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Molecular Carcinogenesis 8:74–80
Park SH, Chi JG, Cho BK, Wang KC (1993) Spinal cord gan-glioglioma in childhood. Pathology, Research and Practice 189:189–196
Park YS, Kim DS, Shim KW, Kim JH, Choi JU (2008) Factors contributing to resectability and seizure outcomes in 44 patients with ganglioglioma. Clinical Neurology and Neu-rosurgery 110:667–673
Pasquier B, Bost F, Peoc'h M, Barnoud R, Pasquier D (1996) Neuropathologic data in drug-resistant partial epilepsy. Report of a series of 195 cases. Annales de Pathologie 16:174–181
Platten M, Meyer-Puttlitz B, Blumcke I, Waha A, Wolf HK, Nothen MM, Louis DN, Sampson JR, von Deimling A (1997) A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas. Journal of Neu-ropathology and Experimental Neurology 56:806–810
Prayson RA, Estes ML (1992) Dysembryoplastic neuroepi-thelial tumor. American Journal of Clinical Pathology 97:398–401
Prayson RA, Khajavi K, Comair YG (1995) Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with intracranial tumors. Journal of Neuropathology and Experimental Neurology 54:513–520
Rades D, Schild SE, Fehlauer F (2004) Defi ning the best available treatment for neurocytomas in children. Cancer 101:2629–2632
Raymond AA, Halpin SF, Alsanjari N, Cook MJ, Kitchen ND, Fish DR, Stevens JM, Harding BN, Scaravilli F, Kendall B et al (1994) Dysembryoplastic neuroepithelial tumor. Features in 16 patients. Brain 117(Pt 3):461–475
Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD (1995) Abnormalities of gyration, heteroto-pias, tuberous sclerosis, focal cortical dysplasia, microdys-genesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. Brain 118 (Pt 3): 629–660
Sasaki A, Hirato J, Nakazato Y, Tamura M, Kadowaki H (1996) Recurrent anaplastic ganglioglioma: pathological characterization of tumor cells. Case report. Journal of Neurosur-gery 84:1055–1059
Schild SE, Scheithauer BW, Haddock MG, Schiff D, Burger PC, Wong WW, Lyons MK (1997) Central neurocytomas. Cancer 79:790–795
Selch MT, Goy BW, Lee SP, El-Sadin S, Kincaid P, Park SH, Withers HR (1998) Gangliogliomas: experience with 34 patients and review of the literature. American Journal of Clinical Oncology 21:557–564
Sgouros S, Carey M, Aluwihare N, Barber P, Jackowski A (1998) Central neurocytoma: a correlative clinicopathologic and radiologic analysis. Surgical Neurology 49:197–204
Sharma MC, Rathore A, Karak AK, Sarkar C (1998) A study of proliferative markers in central neurocytoma. Pathology 30:355–359
Sharma MC, Deb P, Sharma S, Sarkar C (2006) Neurocytoma: a comprehensive review. Neurosurgical Review 29:270–285; discussion 285
Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA (2006) Neurocytoma is a tumor of adult neuronal progenitor cells. Journal of Neuroscience 26:12544–12555
Soylemezoglu F, Scheithauer BW, Esteve J, Kleihues P (1997) Atypical central neurocytoma. Journal of Neuropathology and Experimental Neurology 56:551–556
Sutton LN, Packer RJ, Rorke LB, Bruce DA, Schut L (1983) Cerebral gangliogliomas during childhood. Neurosurgery 13:124–128
Sutton LN, Packer RJ, Zimmerman RA, Bruce DA, Schut L (1987) Cerebral gangliogliomas of childhood. Progress in Experimental Tumor Research 30:239–246
Taratuto AL, Pomata H, Sevlever G, Gallo G, Monges J (1995) Dysembryoplastic neuroepithelial tumor: morphological, immunocytochemical, and deoxyribonucleic acid analyses in a pediatric series. Neurosurgery 36:474–481
Taruscio D, Danesi R, Montaldi A, Cerasoli S, Cenacchi G, Giangaspero F (1997) Nonrandom gain of chromosome 7 in central neurocytoma: a chromosomal analysis and fl uorescence in situ hybridization study. Virchows Archiv 430:47–51
Ventureyra E, Herder S, Mallya BK, Keene D (1986) Temporal lobe gangliogliomas in children. Childs Nervous System 2:63–66
von Deimling A, Janzer R, Kleihues P, Wiestler OD (1990) Patterns of differentiation in central neurocytoma. An immunohistochemical study of eleven biopsies. Acta Neu-ropathologica 79:473–479
von Deimling A, Kleihues P, Saremaslani P, Yasargil MG, Spo-erri O, Sudhof TC, Wiestler OD (1991) Histogenesis and differentiation potential of central neurocytomas. Laboratory Investigation 64:585–591
von Koch CS, Schmidt MH, Uyehara-Lock JH, Berger MS, Chang SM (2003) The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature. Surgical Neurology 60:560–565
Wichmann W, Schubiger O, von Deimling A, Schenker C, Vala-vanis A (1991) Neuroradiology of central neurocytoma. Neuroradiology 33:143–148
Wolf HK, Campos MG, Zentner J, Hufnagel A, Schramm J, Elger CE, Wiestler OD (1993) Surgical pathology of temporal lobe epilepsy. Experience with 216 cases. Journal of Neuropathology and Experimental Neurology 52:499–506
Wolf HK, Muller MB, Spanle M, Zentner J, Schramm J, Wiestler OD (1994) Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases. Acta Neuro-pathologica 88:166–173
Wolf HK, Wellmer J, Muller MB, Wiestler OD, Hufnagel A, Pietsch T (1995) Glioneuronal malformative lesions and dysembryoplastic neuroepithelial tumors in patients with chronic pharmacoresistant epilepsies. Journal of Neuropa-thology and Experimental Neurology 54:245–254
Wolf HK, Buslei R, Blumcke I, Wiestler OD, Pietsch T (1997) Neural antigens in oligodendrogliomas and dysembryo-plastic neuroepithelial tumors. Acta Neuropathologica 94:436–443
Yasargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD (1992) Central neurocytoma: histopathological variants and therapeutic approaches. Journal of Neurosurgery 76:32–37
Yen C P, Sheehan J, Patterson G, Steiner L (2007) Gamma knife surgery for neurocytoma. Journal of Neurosurgery 107:7–12
Yin XL, Pang JC, Hui AB, Ng HK (2000) Detection of chromosomal imbalances in central neurocytomas by using comparative genomic hybridization. Journal of Neurosurgery 93:77–81
Zhu J, Guo SZ, Beggs AH, Maruyama T, Santarius T, Dashner K, Olsen N, Wu JK, Black P (1996) Microsatellite instability analysis of primary human brain tumors. Oncogene 12:1417–1423
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chang, E.F., Gupta, N. (2010). Neuronal Tumors. In: Gupta, N., Banerjee, A., Haas-Kogan, D. (eds) Pediatric CNS Tumors. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87979-4_8
Download citation
DOI: https://doi.org/10.1007/978-3-540-87979-4_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-87976-3
Online ISBN: 978-3-540-87979-4
eBook Packages: MedicineMedicine (R0)