Craniopharyngiomas are histologically benign neuroepithelial tumors that arise from rests of squamous-cell epithelium that remain along the path of the primitive craniopharyngeal duct and adeno-hypophysis. They frequently involve vital structures in the sellar region including the optic apparatus and the pituitary, and often lead to visual, endocrine, and mental disturbances. Despite their benign histology, the involvement of various neural structures in the suprasellar region makes the treatment and management of craniopharyngiomas difficult. There remains an ongoing controversy regarding optimal treatment of craniopharyngiomas. The debate revolves around the risks and benefits of attempted gross total resection as compared to subtotal resection or biopsy followed by other therapy such as external beam radiotherapy, radiosurgery, intracavitary radiation or sclerosis, and/or chemotherapy (Karavitaki et al. 2006).
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Sughrue, M.E., Lustig, R.H., Fisch, B., McDermott, M.W. (2010). Craniopharyngioma. In: Gupta, N., Banerjee, A., Haas-Kogan, D. (eds) Pediatric CNS Tumors. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87979-4_7
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