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Human Brain Myelination from Birth to 4.5 Years

  • Berengere Aubert-Broche
  • Vladimir Fonov
  • Ilana Leppert
  • G. Bruce Pike
  • D. Louis Collins
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5242)

Abstract

The myelination of white matter from birth through the first years of life has been studied qualitatively and it is well know the myelination occurs in a orderly and predictable manner, proceeding in a caudocranial direction, from deep to superficial and from posterior to anterior. Even if the myelination is a continuous process, it is useful to characterize myelination evolution in normal brain development in order to better study demyelinating diseases. The quantification of myelination has only been studied for neonates. The original contribution of this study is to develop a method to characterize and visualize the myelination pattern using MRI data from a group of normal subjects from birth to just over 4 years of age. The method includes brain extraction and tissue classification in addition to the analysis of T2 relaxation times to attempt to separate myelinated and unmyelinated white matter. The results agree previously published qualitative observations.

Keywords

White Matter Gray Matter Normal Brain Development Central Gray Matter White Matter Voxels 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Berengere Aubert-Broche
    • 1
  • Vladimir Fonov
    • 1
  • Ilana Leppert
    • 1
  • G. Bruce Pike
    • 1
  • D. Louis Collins
    • 1
  1. 1.Montreal Neurological InstituteMcGill UniversityMontrealCanada

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