This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Farzan, M.; Schnitzler, C.E.; Vasilieva, N.; Leung, D.; Choe, H.: BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein. Proc. Natl. Acad. Sci. USA, 97, 9712–9717 (2000)
Fluhrer, R.; Capell, A.; Westmeyer, G.; Willem, M.; Hartung, B.; Condron, M.M.; Teplow, D.B.; Haass, C.; Walter, J.: A non-amyloidogenic function of BACE-2 in the secretory pathway. J. Neurochem., 81, 1011–1020 (2002)
Ghosh, A.K.; Bilcer, G.; Harwood, C.; Kawahama, R.; Shin, D.; Hussain, K.A.; Hong, L.; Loy, J.A.; Nguyen, C.; Koelsch, G.; Ermolieff, J.; Tang, J.: Structure-based design: potent inhibitors of human brain memapsin 2 (β-secretase). J. Med. Chem., 44, 2865–2868 (2001)
Kim, Y.-T.; Downs, D.; Wu, S.; Dashti, A.; Pan, Y.; Zhai, P.; Wang, X.; Zhang, X.C.; Lin, X.: Enzymic properties of recombinant BACE2. Eur. J. Biochem., 269, 5668–5677 (2002)
Li, G.; Percontino, L.; Sun, Q.; Qazi, A.S.; Frederikse, P.H.: β-Amyloid secretases and β-amyloid degrading enzyme expression in lens. Mol. Vis., 9, 179–183 (2003)
Motonaga, K.; Itoh, M.; Becker, L.E.; Goto, Y.-I.; Takashima, S.: Elevated expression of β-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome. Neurosci. Lett., 326, 64–66 (2002)
Solans, A.; Estivill, X.; de La Luna, S.: A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer’s amyloid precursor protein β-secretase. Cytogenet. Cell Genet., 89, 177–184 (2000)
Turner, R.T., III; Loy, J.A.; Nguyen, C.; Devasamudram, T.; Ghosh, A.K.; Koelsch, G.; Tang, J.: Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity. Biochemistry, 41, 8742–8746 (2002)
Vattemi, G.; Engel, W.K.; McFerrin, J.; Pastorino, L.; Buxbaum, J.D.; Askanas, V.: BACE1 and BACE2 in pathologic and normal human muscle. Exp. Neurol., 179, 150–158 (2003)
Hussain, I.; Powell, D.J.; Howlett, D.R.; Chapman, G.A.; Gilmour, L.; Murdock, P.R.; Tew, D.G.; Meek, T.D.; Chapman, C.; Schneider, K.; Ratcliffe, S.J.; Tattersall, D.; Testa, T.T.; Southan, C.; Ryan, D.M.; Simmons, D.L.; Walsh, F.S.; Dingwall, C.; Christie, G.: ASP1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site. Mol. Cell. Neurosci., 16, 609–619 (2000)
Tang, J.; Koelsch, G.: Memapsin 1. Handbook of Proteolytic Enzymes (Barrett, J.; Rawlings, N.D.; Woessner, J.F., eds.), 1, 64–66 (2004)
Ostermann, N.; Eder, J.; Eidhoff, U.; Zink, F.; Hassiepen, U.; Worpenberg, S.; Maibaum, J.; Simic, O.; Hommel, U.; Gerhartz, B.: Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J. Mol. Biol., 355, 249–261 (2006)
Lahiri, D.K.; Maloney, B.; Ge, Y.W.: Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells. J. Mol. Neurosci., 29, 65–80 (2006)
Maloney, B.; Ge, Y.W.; Greig, N.H.; Lahiri, D.K.: Characterization of the human β-secretase 2 (BACE2) 5-flanking region: identification of a 268-bp region as the basal BACE2 promoter. J. Mol. Neurosci., 29, 81–99 (2006)
Chou, K.C.: Insights from modeling the tertiary structure of human BACE2. J. Proteome Res., 3, 1069–1072 (2004)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2009). Memapsin 1. In: Chang, A. (eds) Class 3 Hydrolases. Springer Handbook of Enzymes, vol S6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85705-1_23
Download citation
DOI: https://doi.org/10.1007/978-3-540-85705-1_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-85704-4
Online ISBN: 978-3-540-85705-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)