Skip to main content
SpringerLink
Log in
Book cover

Class 3 Hydrolases pp 4–19Cite as

Hormone-sensitive lipase

  • Chapter

  • 734 Accesses

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S5))

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tsujita, T.; Okuda, H.: Hydrolysis of cholesteryl oleate liquid crystals by hormon-sensitive lipase. J. Biochem., 113, 264–269 (1993)

    PubMed  CAS  Google Scholar 

  2. Lee, F.T.; Adams, J.B.; Garton, A.J.; Yeaman, S.J.: Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones. Biochim. Biophys. Acta, 963, 258–264 (1988)

    PubMed  CAS  Google Scholar 

  3. Tsujita, T.; Ninomiya, H.; Okuda, H.: p-Nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue. J. Lipid Res., 30, 997–1004 (1989)

    PubMed  CAS  Google Scholar 

  4. Yeaman, S.J.: Hormone-sensitive lipase — new roles for an old enzyme. Biochem. J., 379, 11–22 (2004)

    Article  PubMed  CAS  Google Scholar 

  5. Yeaman, S.J.; Smith, G.M.; Jepson, C.A.; Wood, S.L.; Emmison, N.: The multifunctional role of hormone-sensitive lipase in lipid metabolism. Adv. Enzyme Regul., 34, 355–370 (1994)

    Article  PubMed  CAS  Google Scholar 

  6. Langfort, J.; Ploug, T.; Ihlemann, J.; Enevoldsen, L.H.; Stallknecht, B.; Saldo, M.; Kjaer, M.; Holm, C.; Galbo, H.: Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle. Adv. Exp. Med. Biol., 441, 219–228 (1998)

    PubMed  CAS  Google Scholar 

  7. Shih, M.F.; Taberner, P.V.: Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to α(2)-adrenoceptor activation bu UK 14304. Alcohol Alcohol, 36, 381–387 (2001)

    PubMed  CAS  Google Scholar 

  8. Holm, C.; Belfrage, P.; Fredrikson, G.: Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue. Biochem. Biophys. Res. Commun., 148, 99–105 (1987)

    Article  PubMed  CAS  Google Scholar 

  9. Remaury, A.; Laurell, H.; Grober, J.; Reynisdottir, S.; Dauzats, M.; Holm, C.; Langin, D.: Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29. Biochem. Biophys. Res. Commun., 207, 175–182 (1995)

    Article  PubMed  CAS  Google Scholar 

  10. Mairal, A.; Melaine, N.; Laurell, H.; Grober, J.; Holst, L.S.; Guillaudeux, T.; Holm, C.; Jegou, B.; Langin, D.: Characterization of a novel testicular form of human hormone-sensitive lipase. Biochem. Biophys. Res. Commun., 291, 286–290 (2002)

    Article  PubMed  CAS  Google Scholar 

  11. Small, C.A.; Garton, A.J.; Yeaman, S.J.: The presence and role of hormone-sensitive lipase in heart muscle. Biochem. J., 258, 67–72 (1989)

    PubMed  CAS  Google Scholar 

  12. Langfort, J.; Ploug, T.; Ihlemann, J.; Saldo, M.; Holm, C.; Galbo, H.: Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle. Biochem. J., 340, 459–465 (1999)

    Article  PubMed  CAS  Google Scholar 

  13. Pease, R.J.; Wiggins, D.; Saggerson, E.D.; Tree, J.; Gibbons, G.F.: Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase. Biochem. J., 341, 453–460 (1999)

    Article  PubMed  CAS  Google Scholar 

  14. Shen, W.-J.; Patel, S.; Natu, V.; Kraemer, F.B.: Mutational analysis of structural features of rat hormone-sensitive lipase. Biochemistry, 37, 8973–8979 (1998)

    Article  PubMed  CAS  Google Scholar 

  15. Shen, W.-J.; Patel, S.; Hong, R.; Kraemer, F.B.: Hormone-sensitive lipase functions as an oligomer. Biochemistry, 39, 2392–2398 (2000)

    Article  PubMed  CAS  Google Scholar 

  16. Ben Ali, Y.; Chahinian, H.; Petry, S.; Muller, G.; Carriere, F.; Verger, R.; Abousalham, A.: Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?. Biochemistry, 43, 9298–9306 (2004)

    Article  PubMed  Google Scholar 

  17. Holm, C.; Belfrage, P.; Fredrikson, G.: Human adipose tissue hormone-sensitive lipase: identification and comparison with other species. Biochim. Biophys. Acta, 1006, 193–197 (1989)

    PubMed  CAS  Google Scholar 

  18. Small, C.A.; Yeaman, S.J.; West, D.W.; Clegg, R.A.: Cholesterol ester hydrolysis and hormone-sensitive lipase in lactating rat mammary tissue. Biochim. Biophys. Acta, 1082, 251–254 (1991)

    PubMed  CAS  Google Scholar 

  19. Cordle, S.R.; Colbran, R.J.; Yeaman, S.J.: Hormone-sensitive lipase from bovine adipose tissue. Biochim. Biophys. Acta, 887, 51–57 (1986)

    Article  PubMed  CAS  Google Scholar 

  20. Lee, F.T.; Yeaman, S.J.; Fredrikson, G.; Stralfors, P.; Belfrage, P.: Hormone-sensitive lipase from swine adipose tissue: identification and some properties. Comp. Biochem. Physiol. B, 80, 609–612 (1985)

    Article  PubMed  CAS  Google Scholar 

  21. Haemmerle, G.; Zimmermann, R.; Zechner, R.: Letting lipids go: hormone-sensitive lipase. Curr. Opin. Lipidol., 14, 289–297 (2003)

    Article  PubMed  CAS  Google Scholar 

  22. Osterlund, T.: Structure-function relationships of hormone-sensitive lipase. Eur. J. Biochem., 268, 1899–1907 (2001)

    Article  PubMed  CAS  Google Scholar 

  23. Holm, C.; Davis, R.C.; Fredrikson, G.; Belfrage, P.; Schotz, M.C.: Expression of biologically active hormone-sensitive lipase in mammalian (COS) cells. FEBS Lett., 285, 139–144 (1991)

    Article  PubMed  CAS  Google Scholar 

  24. Mersmann, H.J.: Lipoprotein and hormone-sensitive lipases in porcine adipose tissue. J. Anim. Sci., 76, 1396–1404 (1998)

    PubMed  CAS  Google Scholar 

  25. Fredrikson, G.; Belfrage, P.: Positional specificity of hormone-sensitive lipase from rat adipose tissue. J. Biol. Chem., 258, 14253–14256 (1983)

    PubMed  CAS  Google Scholar 

  26. Hazel, J.R.; Sidell, B.D.: The substrate specific of hormone-sensitive lipase from adipose tissue of the Antarctic fish Trematomus newnesi. J. Exp. Biol., 207, 897–903 (2004)

    Article  PubMed  CAS  Google Scholar 

  27. Raclot, T.; Holm, C.; Langin, D.: Fatty acid specificity of hormone-sensitive lipase: implication in the selective hydrolysis of triacylglycerols. J. Lipid Res., 42, 2049–2057 (2001)

    PubMed  CAS  Google Scholar 

  28. Awad, A.B.; Chattopadhyay, J.P.: Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes. J. Nutr., 116, 1095–1100 (1986)

    PubMed  CAS  Google Scholar 

  29. Holm, C.; Belfrage, P.; Osterlund, T.; Davis, R.C.; Schotz, M.C.; Langin, D.: Hormone-sensitive lipase: structure, function, evolution and overproduction in insect cells using the baculovirus expression system. Protein Eng., 7, 537–541 (1994)

    Article  PubMed  CAS  Google Scholar 

  30. Wang, J.; Shen, W.J.; Patel, S.; Harada, K.; Kraemer, F.B.: Mutational analysis of the “regulatory module” of hormone-sensitive lipase. Biochemistry, 44, 1953–1959 (2005)

    Article  PubMed  CAS  Google Scholar 

  31. Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta, 1738, 29–36 (2005)

    PubMed  CAS  Google Scholar 

  32. De Jong, J.C.; Sorensen, L.G.; Tornqvist, H.; Jacobsen, P.: Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg. Med. Chem. Lett., 14, 1741–1744 (2004)

    Article  PubMed  Google Scholar 

  33. O’Neill, M.; Watt, M.J.; Heigenhauser, G.J.; Spriet, L.L.: Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise. J. Appl. Physiol., 97, 1938–1945 (2004)

    Article  PubMed  Google Scholar 

  34. Lindvall, H.; Nevsten, P.; Stroem, K.; Wallenberg, R.; Sundler, F.; Langin, D.; Soerhede Winzell, M.; Holm, C.: A novel hormone-sensitive lipase isoform expressed in pancreatic β-cells. J. Biol. Chem., 279, 3828–3836 (2004)

    Article  PubMed  CAS  Google Scholar 

  35. Martin-Hidalgo, A.; Huerta, L.; Alvarez, N.; Alegria, G.; Del Val Toledo, M.; Herrera, E.: Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation. J. Lipid Res., 46, 658–668 (2005)

    Article  PubMed  CAS  Google Scholar 

  36. Ben Ali, Y.; Carriere, F.; Verger, R.; Petry, S.; Muller, G.; Abousalham, A.: Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases. J. Lipid Res., 46, 994–1000 (2005)

    Article  PubMed  Google Scholar 

  37. Claus, T.H.; Lowe, D.B.; Liang, Y.; Salhanick, A.I.; Lubeski, C.K.; Yang, L.; Lemoine, L.; Zhu, J.; Clairmont, K.B.: Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose. J. Pharmacol. Exp. Ther., 315, 1396–1402 (2005)

    Article  PubMed  CAS  Google Scholar 

  38. Roepstorff, C.; Vistisen, B.; Donsmark, M.; Nielsen, J.N.; Galbo, H.; Green, K.A.; Hardie, D.G.; Wojtaszewski, J.F.; Richter, E.A.; Kiens, B.: Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise. J. Physiol., 560, 551–562 (2004)

    Article  PubMed  CAS  Google Scholar 

  39. Kraemer, F.B.; Shen, W.-J.; Harada, K.; Patel, S.; Osuga, J.-I.; Ishibashi, S.; Azhar, S.: Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol. Endocrinol., 18, 549–557 (2004)

    Article  PubMed  CAS  Google Scholar 

  40. Donsmark, M.; Langfort, J.; Holm, C.; Ploug, T.; Galbo, H.: Regulation and role of hormone-sensitive lipase in rat skeletal muscle. Proc. Nutr. Soc., 63, 309–314 (2004)

    Article  PubMed  CAS  Google Scholar 

  41. Watt, M.J.; Spriet, L.L.: Regulation and role of hormone-sensitive lipase activity in human skeletal muscle. Proc. Nutr. Soc., 63, 315–322 (2004)

    Article  PubMed  CAS  Google Scholar 

Download references

Editor information

Editors and Affiliations

  1. Technical University Braunschweig Bioinformatics & Systems Biology, Langer Kamp 19b, 38106, Braunschweig, Germany

    Antje Chang

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2009). Hormone-sensitive lipase. In: Chang, A. (eds) Class 3 Hydrolases. Springer Handbook of Enzymes, vol S5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85703-7_2

Download citation

Publish with us

Policies and ethics

Search

Navigation