Skip to main content

Lipoyl synthase

  • Chapter
  • 881 Accesses

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S4))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bryant, P.; Kriek, M.; Wood, R.J.; Roach, P.L.: The activity of a thermostable lipoyl synthase from Sulfolobus solfataricus with a synthetic octanoyl substrate. Anal. Biochem., 351, 44–49 (2006)

    Article  PubMed  CAS  Google Scholar 

  2. Miller, J.R.; Busby, R.W.; Jordan, S.W.; Cheek, J.; Henshaw, T.F.; Ashley, G.W.; Broderick, J.B.; Cronan, J.E., Jr.; Marletta, M.A.: Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. Biochemistry, 39, 15166–15178 (2000)

    Article  PubMed  CAS  Google Scholar 

  3. Cicchillo, R.M.; Iwig, D.F.; Jones, A.D; Nesbitt, N.M.; Baleanu-Gogonea, C.; Souder, M.G.; Tu, L.; Booker, S.J.: Lipoyl synthase requires two equivalents of S-adenosyl-l-methionine to synthesize one equivalent of lipoic acid. Biochemistry, 43, 6378–6386 (2004)

    Article  PubMed  CAS  Google Scholar 

  4. Zhao, X.; Miller, J.R.; Jiang, Y.; Marletta M.A.; Cronan, J.E.: Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Chem. Biol., 10, 1293–1302 (2003)

    Article  PubMed  CAS  Google Scholar 

  5. Ollagnier-de Choudens, S.; Fontecave, M.: The lipoate synthase from Escherichia coli is an iron-sulfur protein. FEBS Lett., 453, 25–28 (1999)

    Article  PubMed  CAS  Google Scholar 

  6. Thomsen-Zieger, N.; Schachtner, J.; Seeber, F.: Apicomplexan parasites contain a single lipoic acid synthase located in the plastid. FEBS Lett., 547, 80–86 (2003)

    Article  PubMed  CAS  Google Scholar 

  7. Cicchillo, R.M.; Booker, S.J.: Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide. J. Am. Chem. Soc., 127, 2860–2861 (2005)

    Article  PubMed  CAS  Google Scholar 

  8. vanden Boom, T.J.; Reed, K.E.; Cronan, J.E.: Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system. J. Bacteriol., 173, 6411–6420 (1991)

    Google Scholar 

  9. Jordan, S.W.; Cronan, J.E.: A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli. J. Biol. Chem., 272, 17903–17906 (1997)

    Article  PubMed  CAS  Google Scholar 

  10. Kriek, M.; Peters, L.; Takahashi, Y.; Roach, P.L.: Effect of iron-sulfur cluster assembly proteins on the expression of Escherichia coli lipoic acid synthase. Protein Expr. Purif., 28, 241–245 (2003)

    Article  PubMed  CAS  Google Scholar 

  11. Douglas, P.; Kriek, M.; Bryant, P.; Roach, P.L.: Lipoyl synthase inserts sulfur atoms into an octanoyl substrate in a stepwise manner. Angew. Chem., 45, 5197–5199 (2006)

    Article  CAS  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2009). Lipoyl synthase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol S4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85701-3_22

Download citation

Publish with us

Policies and ethics