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Myosin-ligh-chain kinase

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Springer Handbook of Enzymes

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S4))

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References

  1. Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O’Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.: The SWISS-PROT protein knowledgebase and its supplement TrEMBL. Nucleic Acids Res., 31, 365–370 (2003)

    Article  PubMed  CAS  Google Scholar 

  2. Deloukas, P.; Matthews, L.H.; Ashurst, J.; Burton, J.; Gilbert, J.G.; et al.: The DNA sequence and comparative analysis of human chromosome 20. Nature, 414, 865–871 (2001)

    Article  PubMed  CAS  Google Scholar 

  3. Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.: Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity. Trends Biochem. Sci., 19, 440–444 (1994)

    Article  PubMed  CAS  Google Scholar 

  4. Kemp, B.E.; Pearson, R.B.; House, M.: Pseudosubstrate-based peptide inhibitors. Methods Enzymol., 201, 287–304 (1991)

    Article  PubMed  CAS  Google Scholar 

  5. Davis, J.S.; Hassanzadeh, S.; Winitsky, S.; Lin, H.; Satorius, C.; Vemuri, R.; Aletras, A.H.; Wen, H.; Epstein, N.D.: The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. Cell, 107, 631–641 (2001)

    Article  PubMed  CAS  Google Scholar 

  6. Herring, B.P.; Stull, J.T.; Gallagher, P.J.: Domain characterization of rabbit skeletal muscle myosin light chain kinase. J. Biol. Chem., 265, 1724–1730 (1990)

    PubMed  CAS  Google Scholar 

  7. Ikura, M.; Clore, G.M.; Gronenborn, A.M.; Zhu, G.; Klee, C.B.; Bax, A.: Solution structure of a calmodulin-target peptide complex by multidimensional NMR. Science, 256, 632–638 (1992)

    Article  PubMed  CAS  Google Scholar 

  8. Takio, K.; Blumenthal, D.K.; Edelman, A.M.; Walsh, K.A.; Krebs, E.G.; Titani, K.: Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase. Biochemistry, 24, 6028–6037 (1985)

    Article  PubMed  CAS  Google Scholar 

  9. Takio, K.; Blumenthal, D.K.; Walsh, K.A.; Titani, K.; Krebs, E.G.: Amino acid sequence of rabbit skeletal muscle myosin light chain kinase. Biochemistry, 25, 8049–8057 (1986)

    Article  PubMed  CAS  Google Scholar 

  10. Collinge, M.; Matrisian, P.E.; Zimmer, W.E.; Shattuck, R.L.; Lukas, T.J.; Van Eldik, L.J.; Watterson, D.M.: Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. Mol. Cell. Biol., 12, 2359–2371 (1992)

    PubMed  CAS  Google Scholar 

  11. Guerriero, V., Jr.; Russo, M.A.; Olson, N.J.; Putkey, J.A.; Means, A.R.: Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA. Biochemistry, 25, 8372–8381 (1986)

    Article  PubMed  CAS  Google Scholar 

  12. Olson, N.J.; Pearson, R.B.; Needleman, D.S.; Hurwitz, M.Y.; Kemp, B.E.; Means, A.R.: Regulatory and structural motifs of chicken gizzard myosin light chain kinase. Proc. Natl. Acad. Sci. USA, 87, 2284–2288 (1990)

    Article  PubMed  CAS  Google Scholar 

  13. Shoemaker, M.O.; Lau, W.; Shattuck, R.L.; Kwiatkowski, A.P.; Matrisian, P.E.; Guerra-Santos, L.; Wilson, E.; Lukas, T.J.; Van Eldik, L.J.; Watterson, D.M.: Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity. J. Cell. Biochem. 111, 1107–1125 (1990)

    CAS  Google Scholar 

  14. Watterson, D.M.; Collinge, M.; Lukas, T.J.; Van Eldik, L.J.; Birukov, K.G.; Stepanova, O.V.; Shirinsky, V.P.: Multiple gene products are produced from a novel protein kinase transcription region. FEBS Lett., 373, 217–220 (1995)

    Article  PubMed  CAS  Google Scholar 

  15. Yoshikai, S.; Ikebe, M.: Molecular cloning of the chicken gizzard telokin gene and cDNA. Arch. Biochem. Biophys., 299, 242–247 (1992)

    Article  PubMed  CAS  Google Scholar 

  16. Roush, C.L.; Kennelly, P.J.; Glaccum, M.B.; Helfman, D.M.; Scott, J.D.; Krebs, E.G.: Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution. J. Biol. Chem., 263, 10510–10516 (1988)

    PubMed  CAS  Google Scholar 

  17. Tan, J.L.; Spudich, J.A.: Characterization and bacterial expression of the Dictyostelium myosin light chain kinase cDNA. Identification of an autoinhibitory domain. J. Biol. Chem., 266, 16044–16049 (1991)

    PubMed  CAS  Google Scholar 

  18. Tan, J.L.; Spudich, J.A.: Dictyostelium myosin light chain kinase. Purification and characterization. J. Biol. Chem., 265, 13818–13824 (1990)

    PubMed  CAS  Google Scholar 

  19. Gallagher, P.J.; Herring, B.P.; Griffin, S.A.; Stull, J.T.: Molecular characterization of a mammalian smooth muscle myosin light chain kinase [published erratum appears in J Biol Chem 1992 May 5;267(13):9450]. J. Biol. Chem., 266, 23936–23944 (1991)

    PubMed  CAS  Google Scholar 

  20. Gallagher, P.J.; Herring, B.P.: The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin. J. Biol. Chem., 266, 23945–23952 (1991)

    PubMed  CAS  Google Scholar 

  21. Garcia, J.G.N.; Lazar, V.; Gilbert-McClain, L.I.; Gallagher, P.J.; Verin, A.D.: Myosin light chain kinase in endothelium: molecular cloning and regulation. Am. J. Respir. Cell Mol. Biol. 16, 489–494 (1997)

    PubMed  CAS  Google Scholar 

  22. Lazar, V.; Garcia, J.G.: A single human myosin light chain kinase gene (MLCK; MYLK). Genomics, 57, 256–267 (1999)

    Article  PubMed  CAS  Google Scholar 

  23. Potier, M.C.; Chelot, E.; Pekarsky, Y.; Gardiner, K.; Rossier, J.; Turnell, W.G.: The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. Genomics, 29, 562–570 (1995)

    Article  PubMed  CAS  Google Scholar 

  24. Watterson, D.M.; Schavocky, J.P.; Guo, L.; Weiss, C.; Chlenski, A.; Shirinsky, V.P.; Van Eldik, L.J.; Haiech, J.: Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker. J. Cell. Biochem., 75, 481–491 (1999)

    Article  PubMed  CAS  Google Scholar 

  25. Kobayashi, H.; Inoue, A.; Mikawa, T.; Kuwayama, H.; Hotta, Y.; Masaki, T.; Ebashi, S.: Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity. J. Biochem., 112, 786–791 (1992)

    PubMed  CAS  Google Scholar 

  26. Pires, E.; Perry, S.V.; Thomas, M.A.W.: Myosin light-chain kinase, a new enzyme from striated muscle. FEBS Lett., 41, 292–296 (1974)

    Article  PubMed  CAS  Google Scholar 

  27. Pires, E.M.V.; Perry, S.V.: Purification and properties of myosin lightchain kinase from fast skeletal muscle. Biochem. J., 167, 137–146 (1977)

    PubMed  CAS  Google Scholar 

  28. Nagamoto, H.; Yagi, K.: Properties of myosin light chain kinase prepared from rabbit skeletal muscle by an improved method. J. Biochem., 95, 1119–1130 (1984)

    PubMed  CAS  Google Scholar 

  29. Yang, H.H.; Boxer, L.A.: Purification of myosin light chain kinase from rabbit polymorphonuclear leukocytes. Pediatr. Res., 15, 229–234 (1981)

    PubMed  CAS  Google Scholar 

  30. Hathaway, D.R.; Adelstein, R.S.: Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity. Proc. Natl. Acad. Sci. USA, 76, 1653–1657 (1979)

    Article  PubMed  CAS  Google Scholar 

  31. Serventi, I.M.; Coffee, C.J.: Characterization of myosin light-chain kinase from bovine adrenal medulla. Arch. Biochem. Biophys., 245, 379–388 (1986)

    Article  PubMed  CAS  Google Scholar 

  32. Walsh, M.P.; Hinkins, S.; Flink, I.L.; Hartshorne, D.J.: Bovine stomach myosin light chain kinase: purification, characterization, and comparison with the turkey gizzard enzyme. Biochemistry, 21, 6890–6896 (1982)

    Article  PubMed  CAS  Google Scholar 

  33. Walsh, M.P.; Vallet, B.; Autric, F.; Demaille, J.G.: Purification and characterization of bovine cardiac calmodulin-dependent myosin light chain kinase. J. Biol. Chem., 254, 12136–12144 (1979)

    PubMed  CAS  Google Scholar 

  34. Wolf, H.; Hofmann, F.: Purification of myosin light chain kinase from bovine cardiac muscle. Proc. Natl. Acad. Sci. USA, 77, 5852–5855 (1980)

    Article  PubMed  CAS  Google Scholar 

  35. Bartelt, D.C.; Moroney, S.; Wolff, D.J.: Purification, characterization and substrate specificity of calmodulin-dependent myosin light-chain kinase from bovine brain. Biochem. J., 247, 747–756 (1987)

    PubMed  CAS  Google Scholar 

  36. Yamazaki, K.; Itoh, K.; Sobue, K.; Mori, T.; Shibata, N.: Purification of caldesmon and myosin light chain (MLC) kinase from arterial smooth muscle: comparisons with gizzard caldesmon and MLC kinase. J. Biochem., 101, 1–9 (1987)

    PubMed  CAS  Google Scholar 

  37. Rogers, J.C.; Williams, D.L.: Kaempferol inhibits myosin light chain kinase. Biochem. Biophys. Res. Commun., 164, 419–425 (1989)

    Article  PubMed  CAS  Google Scholar 

  38. Pato, M.D.; Lye, S.J.; Kerc, E.: Purification and characterization of pregnant sheep myometrium myosin light chain kinase. Arch. Biochem. Biophys., 287, 24–32 (1991)

    Article  PubMed  CAS  Google Scholar 

  39. Higashi, K.; Fukunaga, K.; Matsui, K.; Maeyama, M.; Miyamoto, E.: Purification and characterization of myosin light-chain kinase from porcine myometrium and its phosphorylation and modulation by cyclic AMP-dependent protein kinase. Biochim. Biophys. Acta, 747, 232–240 (1983)

    PubMed  CAS  Google Scholar 

  40. Bissonnette, M.; Kuhn, D.; de Lanerolle, P.: Purification and characterization of myosin light-chain kinase from the rat pancreas. Biochem. J., 258, 739–747 (1989)

    PubMed  CAS  Google Scholar 

  41. Jinsart, W.; Ternai, B.; Polya, G.M.: Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca2+-dependent protein kinase by anthraquinones. Biol. Chem. Hoppe-Seyler, 373, 903–910 (1992)

    PubMed  CAS  Google Scholar 

  42. Adelstein, R.S.; Klee, C.B.: Purification and characterization of smooth muscle myosin light chain kinase. J. Biol. Chem., 256, 7501–7509 (1981)

    PubMed  CAS  Google Scholar 

  43. Adelstein, R.S.; Klee, C.B.: Purification of smooth muscle myosin light-chain kinase. Methods Enzymol., 85, 298–308 (1982)

    Article  PubMed  CAS  Google Scholar 

  44. Conti, M.A.; Adelstein, R.S.: Purification and properties of myosin light chain kinases. Methods Enzymol., 196, 34–47 (1991)

    Article  PubMed  CAS  Google Scholar 

  45. Nunnally, M.H.; Rybicki, S.B.; Stull, J.T.: Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes. J. Biol. Chem., 260, 1020–1026 (1985)

    PubMed  CAS  Google Scholar 

  46. Leachman, S.A.; Gallagher, P.J.; Herring, B.P.; McPhaul, M.J.; Stull, J.T.: Biochemical properties of chimeric skeletal and smooth muscle myosin light chain kinases. J. Biol. Chem., 267, 4930–4938 (1992)

    PubMed  CAS  Google Scholar 

  47. Bailin, G.: Structure and function of a calmodulin-dependent smooth muscle myosin light chain kinase. Experientia, 40, 1185–1188 (1984)

    Article  PubMed  CAS  Google Scholar 

  48. Sellers, J.R.; Harvey, E.V.: Purification of myosin light chain kinase from Limulus muscle. Biochemistry, 23, 5821–5826 (1984)

    Article  PubMed  CAS  Google Scholar 

  49. Ikebe, M.; Reardon, S.; Fay, F.S.: Primary structure required for the inhibition of smooth muscle myosin light chain kinase. FEBS Lett., 312, 245–248 (1992)

    Article  PubMed  CAS  Google Scholar 

  50. Jinsart, W.; Ternai, B.; Polya, G.M.: Inhibition of wheat embryo calciumdependent protein kinase and avian myosin light chain kinase by flavonoids and related compounds. Biol. Chem. Hoppe-Seyler, 372, 819–827 (1991)

    PubMed  CAS  Google Scholar 

  51. Nakanishi, S.; Kakita, S.; Takahashi, I.; Kawahara, K.; Tsukada, E.; Sano, T.; Yamada, K.; Yoshida, M.; Kase, H.; Matsuda, Y.; Hashimoto, Y.; Nonomura, Y.: Wortmannin, a microbial product inhibitor of myosin light chain kinase. J. Biol. Chem., 267, 2157–2163 (1992)

    PubMed  CAS  Google Scholar 

  52. Kigoshi, T.; Uchida, K.; Kaneko, M.; Iwasaki, R.; Nakano, S.; Azukizawa, S.; Morimoto, S.: Direct inhibition of smooth muscle myosin light chain kinase by arachidonic acid in a purified system. Biochem. Biophys. Res. Commun., 171, 369–374 (1990)

    Article  PubMed  CAS  Google Scholar 

  53. Higashihara, M.: Inhibition of myosin light chain kinase by amiloride. Biochem. Biophys. Res. Commun., 162, 1253–1259 (1989)

    Article  PubMed  CAS  Google Scholar 

  54. Nakanishi, S.; Ando, K.; Kawamoto, I.; Matsuda, Y.: MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178. J. Antibiot., 46, 1775–1781 (1989)

    Google Scholar 

  55. Jinsart, W.; Ternai, B.; Polya, G.M.: Inhibition and activation of wheat embryo calcium-dependent protein kinase and inhibition of avian myosin light chain kinase by long chain aliphatic amphiphiles. Plant Sci., 78, 165–175 (1991)

    Article  CAS  Google Scholar 

  56. Stull, J.T.; Nunnally, M.H.; Michnoff, C.H. in: Calmoduline-dependent protein kinases. The Enzymes, 3rd. Ed. (Boyer, P.D., Krebs, E.G., eds.), 17, 113–166 (1986)

    Google Scholar 

  57. Verin, A.D.; Gilbert-McClain, L.I.; Patterson, C.E.; Garcia, J.G.N.: Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium. Am. J. Respir. Cell Mol. Biol., 19, 767–776 (1998)

    PubMed  CAS  Google Scholar 

  58. Fujita, K.; Ye, L.-H.; Sato, M.; Okagaki, T.; Nagamachi, Y.; Kohama, K.: Myosin light chain kinase from skeletal muscle regulates an ATP-dependent interaction between actin and myosin by binding to actin. Mol. Cell. Biochem., 190, 85–90 (1999)

    Article  PubMed  CAS  Google Scholar 

  59. Okagaki, T.; Ye, L.H.; Samizo, K.; Tanaka, T.; Kohama, K.: Inhibitory effect of the catalytic domain of myosin light chain kinase on actin-myosin interaction: insight into the mode of inhibition. J. Biochem., 125, 1055–1060 (1999)

    PubMed  CAS  Google Scholar 

  60. Okagaki, T.; Hayakawa, K.; Samizo, K.; Kohama, K.: Inhibition of the ATP-dependent interaction of actin and myosin by the catalytic domain of the myosin light chain kinase of smooth muscle: possible involvement in smooth muscle relaxation. J. Biochem., 125, 619–626 (1999)

    PubMed  CAS  Google Scholar 

  61. Hayakawa, K.; Okagaki, T.; Ye, L.H.; Samizo, K.; Higashi-Fujime, S.; Takagi, T.; Kohama, K.: Characterization of the myosin light chain kinase from smooth muscle as an actin-binding protein that assembles actin filaments in vitro. Biochim. Biophys. Acta, 1450, 12–24 (1999)

    Article  PubMed  CAS  Google Scholar 

  62. Sobieszek, A.; Andruchov, O.Y.; Nieznanski, K.: Kinase-related protein (telokin) is phosphorylated by smooth-muscle myosin light-chain kinase and modulates the kinase activity. Biochem. J., 328, 425–430 (1997)

    PubMed  CAS  Google Scholar 

  63. Edwards, R.A.; Walsh, M.P.; Sutherland, C.; Vogel, H.J.: Activation of calcineurin and smooth muscle myosin light chain kinase by Met-to-Leu mutants of calmodulin. Biochem. J., 331, 149–152 (1998)

    PubMed  CAS  Google Scholar 

  64. Sobieszek, A.; Borkowski, J.; Babiychuk, V.S.: Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex. J. Biol. Chem., 272, 7034–7041 (1997)

    Article  PubMed  CAS  Google Scholar 

  65. Van Lierop, J.E.; Wilson, D.P.; Davis, J.P.; Tikunova, S.; Sutherland, C.; Walsh, M.P.; Johnson, J.D.: Activation of smooth muscle myosin light chain kinase by calmodulin. Role of Lys30 and Gly40. J. Biol. Chem., 277, 6550–6558 (2002)

    Article  PubMed  CAS  Google Scholar 

  66. Champagne, M.B.; Edwards, K.A.; Erickson, H.P.; Kiehart, D.P.: Drosophila stretchin-MLCK is a novel member of the titin/myosin light chain kinase family. J. Mol. Biol., 300, 759–777 (2000)

    Article  PubMed  CAS  Google Scholar 

  67. Sanders, L.C.; Matsumura, F.; Bokoch, G.M.; de Lanerolle, P.: Inhibition of myosin light chain kinase by p21-activated kinase. Science, 283, 2083–2085 (1999)

    Article  PubMed  CAS  Google Scholar 

  68. Gao, Z.-H.; Zhi, G.; Herring, B.P.; Moomaw, C.; Deogny, L.; Slaughter, C.A.; Stull, J.T.: Photoaffinity labeling of a peptide substrate to myosin light chain kinase. J. Biol. Chem., 270, 10125–10135 (1995)

    Article  PubMed  CAS  Google Scholar 

  69. Toeroek, K.; Cowley, D.J.; Brandmeier, B.D.; Howell, S.; Aitken, A.; Trentham, D.R.: Inhibition of calmodulin-activated smooth-muscle myosin light-chain kinase by calmodulin-binding peptides and fluorescent (phosphodiesterase-activating) calmodulin derivatives. Biochemistry, 37, 6188–6198 (1998)

    Article  CAS  Google Scholar 

  70. Lin, P.; Luby-Phelps, K.; Stull, J.T.: Properties of filament-bound myosin light chain kinase. J. Biol. Chem., 274, 5987–5994 (1999)

    Article  PubMed  CAS  Google Scholar 

  71. Padre, R.C.; Stull, J.T.: Conformational requirements for Ca2+/calmodulin binding and activation of myosin light chain kinase. FEBS Lett., 472, 148–152 (2000)

    Article  PubMed  CAS  Google Scholar 

  72. Smith, L.; Parizi-Robinson, M.; Zhu, M.S.; Zhi, G.; Fukui, R.; Kamm, K.E.; Stull, J.T.: Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo. J. Biol. Chem., 277, 35597–35604 (2002)

    Article  PubMed  CAS  Google Scholar 

  73. Dudek, S.M.; Birukov, K.G.; Zhan, X.; Garcia, J.G.N.: Novel interaction of cortactin with endothelial cell myosin light chain kinase. Biochem. Biophys. Res. Commun., 298, 511–519 (2002)

    Article  PubMed  CAS  Google Scholar 

  74. Watterson, D.M.; Schavocky, J.P.; Guo, L.; Weiss, C.; Chlenski, A.; Shirinsky, V.P.; Van Eldik, L.J.; Haiech, J.: Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker. J. Cell Biochem., 75, 481–491 (1999)

    Article  PubMed  CAS  Google Scholar 

  75. Gao, Y.; Kawano, K.; Yoshiyama, S.; Kawamichi, H.; Wang, X.; Nakamura, A.; Kohama, K.: Myosin light chain kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain. Biochem. Biophys. Res. Commun., 305, 16–21 (2003)

    Article  PubMed  CAS  Google Scholar 

  76. Yanase, M.; Ikeda, H.; Ogata, I.; Matsui, A.; Noiri, E.; Tomiya, T.; Arai, M.; Inoue, Y.; Tejima, K.; Nagashima, K.; Nishikawa, T.; Shibata, M.; Ikebe, M.; Rojkind, M.; Fujiwara, K.: Functional diversity between Rho-kinase-and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line. Biochem. Biophys. Res. Commun., 305, 223–228 (2003)

    Article  PubMed  CAS  Google Scholar 

  77. Grimm, M.; Haas, P.; Willipinski-Stapelfeldt, B.; Zimmermann, W.H.; Rau, T.; Pantel, K.; Weyand, M.; Eschenhagen, T.: Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the α 1-adrenergic positive inotropic effect in human atrium. Cardiovasc. Res., 65, 211–220 (2005)

    Article  PubMed  CAS  Google Scholar 

  78. Deng, M.; Williams, C.J.; Schultz, R.M.: Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity. Dev. Biol., 278, 358–366 (2005)

    Article  PubMed  CAS  Google Scholar 

  79. Kudryashov, D.S.; Stepanova, O.V.; Vilitkevich, E.L.; Nikonenko, T.A.; Nadezhdina, E.S.; Shanina, N.A.; Lukas, T.J.; Van Eldik, L.J.; Watterson, D.M.; Shirinsky, V.P.: Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Exp. Cell Res., 298, 407–417 (2004)

    Article  PubMed  CAS  Google Scholar 

  80. Dulyaninova, N.G.; Bresnick, A.R.: The long myosin light chain kinase is differentially phosphorylated during interphase and mitosis. Exp. Cell Res., 299, 303–314 (2004)

    Article  PubMed  CAS  Google Scholar 

  81. Geguchadze, R.; Zhi, G.; Lau, K.S.; Isotani, E.; Persechini, A.; Kamm, K.E.; Stull, J.T.: Quantitative measurements of Ca2+/calmodulin binding and activation of myosin light chain kinase in cells. FEBS Lett., 557, 121–124 (2004)

    Article  PubMed  CAS  Google Scholar 

  82. Adachi, T.; Stafford, S.; Kayaba, H.; Chihara, J.; Alam, R.: Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner. J. Allergy Clin. Immunol., 111, 113–116 (2003)

    Article  PubMed  CAS  Google Scholar 

  83. Tokumitsu, H.; Hatano, N.; Inuzuka, H.; Ishikawa, Y.; Uyeda, T.Q.; Smith, J.L.; Kobayashi, R.: Regulatory mechanism of Dictyostelium myosin light chain kinase A. J. Biol. Chem., 279, 42–50 (2004)

    Article  PubMed  CAS  Google Scholar 

  84. Clayburgh, D.R.; Rosen, S.; Witkowski, E.D.; Wang, F.; Blair, S.; Dudek, S.; Garcia, J.G.; Alverdy, J.C.; Turner, J.R.: A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J. Biol. Chem., 279, 55506–55513 (2004)

    Article  PubMed  CAS  Google Scholar 

  85. Wadgaonkar, R.; Nurmukhambetova, S.; Zaiman, A.L.; Garcia, J.G.: Mutation analysis of the non-muscle myosin light chain kinase (MLCK) deletion constructs on CV1 fibroblast contractile activity and proliferation. J. Cell. Biochem., 88, 623–634 (2003)

    Article  PubMed  CAS  Google Scholar 

  86. Wadgaonkar, R.; Linz-McGillem, L.; Zaiman, A.L.; Garcia, J.G.: Endothelial cell myosin light chain kinase (MLCK) regulates TNFα-induced NFκB activity. J. Cell. Biochem., 94, 351–364 (2005)

    Article  PubMed  CAS  Google Scholar 

  87. Wadgaonkar, R.; Dudek, S.M.; Zaiman, A.L.; Linz-McGillem, L.; Verin, A.D.; Nurmukhambetova, S.; Romer, L.H.; Garcia, J.G.: Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium. J. Cell. Biochem., 95, 849–858 (2005)

    Article  PubMed  CAS  Google Scholar 

  88. Tinsley, J.H.; Yuan, S.Y.; Wilson, E.: Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease. Trends Pharmacol. Sci., 25, 64–66 (2004)

    Article  PubMed  CAS  Google Scholar 

  89. Zhu, H.Q.; Wang, Y.; Hu, R.L.; Ren, B.; Zhou, Q.; Jiang, Z.K.; Gui, S.Y.: Distribution and expression of non-muscle myosin light chain kinase in rabbit livers. World J. Gastroenterol., 9, 2715–2719 (2003)

    PubMed  CAS  Google Scholar 

  90. Herring, B.P.; El-Mounayri, O.; Gallagher, P.J.; Yin, F.; Zhou, J.: Regulation of and telokin expression in smooth muscle tissues. Am. J. Physiol., 291, C817–C827 (2006)

    Article  CAS  Google Scholar 

  91. Niggli, V.; Schmid, M.; Nievergelt, A.: Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells. Biochem. Biophys. Res. Commun., 343, 602–608 (2008)

    Article  CAS  Google Scholar 

  92. Dudnakova, T.V.; Stepanova, O.V.; Dergilev, K.V.; Chadin, A.V.; Shekhonin, B.V.; Watterson, D.M.; Shirinsky, V.P.: Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes. Cell Motil. Cytoskeleton, 63, 375–383 (2006)

    Article  PubMed  CAS  Google Scholar 

  93. Yang, C.X.; Chen, H.Q.; Chen, C.; Yu, W.P.; Zhang, W.C.; Peng, Y.J.; He, W.Q.; Wei, D.M.; Gao, X.; Zhu, M.S.: Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase. Cell Res., 16, 367–376 (2006)

    Article  PubMed  CAS  Google Scholar 

  94. Gu, L.Z.; Hu, W.Y.; Antic, N.; Mehta, R.; Turner, J.R.; de Lanerolle, P.: Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells. Eur. J. Cancer, 42, 948–957 (2006)

    Article  PubMed  CAS  Google Scholar 

  95. Behling-Kelly, E.; McClenahan, D.; Kim, K.S.; Czuprynski, C.J.: Viable “Haemophilus somnus” induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance. Infect. Immun., 75, 4572–4581 (2007)

    Article  PubMed  CAS  Google Scholar 

  96. Zhu, H.; Zhang, X.; Zuo, L.; Zhou, Q.; Gui, S.; Wei, W.; Wang, Y.: Expression of myosin light chain kinase in kidney of streptozotocin-induced diabetic rats. Int. J. Mol. Sci., 7, 510–518 (2006)

    Article  CAS  Google Scholar 

  97. Ryder, J.W.; Lau, K.S.; Kamm, K.E.; Stull, J.T.: Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulinsensing kinase. J. Biol. Chem., 282, 20447–20454 (2007)

    Article  PubMed  CAS  Google Scholar 

  98. Connell, L.E.; Helfman, D.M.: Myosin light chain kinase plays a role in the regulation of epithelial cell survival. J. Cell Sci., 119, 2269–2281 (2006)

    Article  PubMed  CAS  Google Scholar 

  99. Seguchi, O.; Takashima, S.; Yamazaki, S.; Asakura, M.; Asano, Y.; Shintani, Y.; Wakeno, M.; Minamino, T.; Kondo, H.; Furukawa, H.; Nakamaru, K.; Naito, A.; Takahashi, T.; Ohtsuka, T.; Kawakami, K.; Isomura, T.; Kitamura, S.; Tomoike, H.; Mochizuki, N.; Kitakaze, M.: A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J. Clin. Invest., 117, 2812–2824 (2007)

    Article  PubMed  CAS  Google Scholar 

  100. Afonso, P.V.; Ozden, S.; Prevost, M.C.; Schmitt, C.; Seilhean, D.; Weksler, B.; Couraud, P.O.; Gessain, A.; Romero, I.A.; Ceccaldi, P.E.: Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization. J. Immunol., 179, 2576–2583 (2007)

    PubMed  CAS  Google Scholar 

  101. Tokuoka, H.; Goda, Y.: Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons. J. Neurosci., 26, 11606–11614 (2006)

    Article  PubMed  CAS  Google Scholar 

  102. Shimizu, S.; Yoshida, T.; Wakamori, M.; Ishii, M.; Okada, T.; Takahashi, M.; Seto, M.; Sakurada, K.; Kiuchi, Y.; Mori, Y.: Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. J. Physiol., 570, 219–235 (2006)

    PubMed  CAS  Google Scholar 

  103. Blair, S.A.; Kane, S.V.; Clayburgh, D.R.; Turner, J.R.: Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab. Invest., 86, 191–201 (2006)

    Article  PubMed  CAS  Google Scholar 

  104. Lucero, A.; Stack, C.; Bresnick, A.R.; Shuster, C.B.: A global, myosin light chain kinase-dependent increase in myosin II contractility accompanies the metaphase-anaphase transition in sea urchin eggs. Mol. Biol. Cell, 17, 4093–4104 (2006)

    Article  PubMed  CAS  Google Scholar 

  105. Lamprecht, R.; Margulies, D.S.; Farb, C.R.; Hou, M.; Johnson, L.R.; Le-Doux, J.E.; Myosin light chain kinase regulates synaptic plasticity and fear learning in the lateral amygdala. Neuroscience, 139, 821–829 (2006)

    Article  PubMed  CAS  Google Scholar 

  106. Reynoso, R.; Perrin, R.M.; Breslin, J.W.; Daines, D.A.; Watson, K.D.; Watterson, D.M.; Wu, M.H.; Yuan, S.: A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns. Shock, 28, 589–595 (2007)

    PubMed  CAS  Google Scholar 

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  1. Bioinformatics & Systems Biology, Technical University Braunschweig, Langer Kamp 19b, 38106, Braunschweig, Germany

    Dietmar Schomburg , Ida Schomburg  & Antje Chang ,  & 

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(2009). Myosin-ligh-chain kinase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol S4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85701-3_2

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