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IκB kinase

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Class 2 Transferases

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S3))

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References

  1. Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.: Functional annotation of a full-length mouse cDNA collection. Nature, 409, 685–690 (2001)

    Article  PubMed  Google Scholar 

  2. Hu, M.C.; Wang, Y.: IκB kinase-α and-β genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. Gene, 222, 31–40 (1998)

    Article  PubMed  CAS  Google Scholar 

  3. Jobin, C.; Sartor, R.B.: The I κ B/NF-κ B system: a key determinant of mucosalinflammation and protection. Am. J. Physiol., 278, C451–462 (2000)

    CAS  Google Scholar 

  4. Mercurio, F.; Zhu, H.; Murray, B.W.; Shevchenko, A.; Bennett, B.L.; Li, J.; Young, D.B.; Barbosa, M.; Mann, M.; Manning, A.; Rao, A.: IKK-1 and IKK-2: cytokine-activated IkB kinases essential for NF-κB activation. Science, 278, 860–866 (1997)

    Article  PubMed  CAS  Google Scholar 

  5. Nemoto, S.; DiDonato, J.A.; Lin, A.: Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase. Mol. Cell. Biol., 18, 7336–7343 (1998)

    PubMed  CAS  Google Scholar 

  6. Shindo, M.; Nakano, H.; Sakon, S.; Yagita, H.; Mihara, M.; Okumura, K.: Assignment of IkB kinase β (IKBKB) to human chromosome band 8p12-]p11 by in situ hybridization. Cytogenet. Cell Genet., 82, 32–33 (1998)

    Article  PubMed  CAS  Google Scholar 

  7. Woronicz, J.D.; Gao, X.; Cao, Z.; Rothe, M.; Goeddel, D.V.: IκB kinase-β: NF-κB activation and complex formation with IkB kinase-α and NIK. Science, 278, 866–869 (1997)

    Article  PubMed  CAS  Google Scholar 

  8. Wu, R.C.; Qin, J.; Hashimoto, Y.; Wong, J.; Xu, J.; Tsai, S.Y.; Tsai, M.J.; O’Malley, B.W.: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I κ B kinase. Mol. Cell. Biol., 22, 3549–3561 (2002)

    Article  PubMed  CAS  Google Scholar 

  9. Connelly, M.A.; Marcu, K.B.: CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell. Mol. Biol. Res., 41, 537–549 (1995)

    PubMed  CAS  Google Scholar 

  10. Delhase, M.; Hayakawa, M.; Chen, Y.; Karin, M.: Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science, 284, 309–313 (1999)

    Article  PubMed  CAS  Google Scholar 

  11. DiDonato, J.A.; Hayakawa, M.; Rothwarf, D.M.; Zandi, E.; Karin, M.: A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature, 388, 548–554 (1997)

    Article  PubMed  CAS  Google Scholar 

  12. Ling, L.; Cao, Z.; Goeddel, D.V.: NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA, 95, 3792–3797 (1998)

    Article  PubMed  CAS  Google Scholar 

  13. Ozes, O.N.; Mayo, L.D.; Gustin, J.A.; Pfeffer, S.R.; Pfeffer, L.M.; Donner, D.B.: NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature, 401, 82–85 (1999)

    Article  PubMed  CAS  Google Scholar 

  14. Regnier, C.H.; Song, H.Y.; Gao, X.; Goeddel, D.V.; Cao, Z.; Rothe, M.: Identification and characterization of an IκB kinase. Cell, 90, 373–383 (1997)

    Article  PubMed  CAS  Google Scholar 

  15. Hu, M.C.; Wang, Y.; Qiu, W.R.; Mikhail, A.; Meyer, C.F.; Tan, T.H.: Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkB kinases (IKK-α/β) and IKK-β is a developmentally regulated protein kinase. Oncogene, 18, 5514–5524 (1999)

    Article  PubMed  CAS  Google Scholar 

  16. Nakano, H.; Shindo, M.; Sakon, S.; Nishinaka, S.; Mihara, M.; Yagita, H.; Okumura, K.: Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA, 95, 3537–3542 (1998)

    Article  PubMed  CAS  Google Scholar 

  17. Munoz-Dorado, J.; Inouye, S.; Inouye, M.: A gene encoding a protein serine/ threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium. Cell, 67, 995–1006 (1991)

    Article  PubMed  CAS  Google Scholar 

  18. Nagase, T.; Seki, N.; Tanaka, A.; Ishikawa, K.; Nomura, N.: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res., 2; 167–174, 199–210 (1995)

    Article  PubMed  CAS  Google Scholar 

  19. Peters, R.T.; Liao, S.M.; Maniatis, T.: IKKε is part of a novel PMA-inducible IκB kinase complex. Mol. Cell, 5, 513–522 (2000)

    Article  PubMed  CAS  Google Scholar 

  20. Shimada, T.; Kawai, T.; Takeda, K.; Matsumoto, M.; Inoue, J.; Tatsumi, Y.; Kanamaru, A.; Akira, S.: IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases. Int. Immunol., 11, 1357–1362 (1999)

    Article  PubMed  CAS  Google Scholar 

  21. McKenzie, F.R.; Connelly, M.A.; Balzarano, D.; Muller, J.R.; Geleziunas, R.; Marcu, K.B.: Functional isoforms of IκB kinase α (IKKα) lacking leucine zipper and helix-loop-helix domains reveal that IKKα and IKKβ have different activation requirements. Mol. Cell. Biol., 20, 2635–2649 (2000)

    Article  PubMed  CAS  Google Scholar 

  22. Mock, B.A.; Connelly, M.A.; McBride, O.W.; Kozak, C.A.; Marcu, K.B.: CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics, 27, 348–351 (1995)

    Article  PubMed  CAS  Google Scholar 

  23. Amici, C.; Belardo, G.; Rozera, C.; Bernasconi, D.; Santoro, M.G.: Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IκB kinase (IKK). Aids, 18, 1271–1280 (2004)

    Article  PubMed  CAS  Google Scholar 

  24. Castro, A.C.; Dang, L.C.; Soucy, F.; Grenier, L.; Mazdiyasni, H.; Hottelet, M.; Parent, L.; Pien, C.; Palombella, V.; Adams, J.: Novel IKK inhibitors: β-carbolines. Bioorg. Med. Chem. Lett., 13, 2419–2422 (2003)

    Article  PubMed  CAS  Google Scholar 

  25. Waelchli, R.; Bollbuck, B.; Bruns, C.; Buhl, T.; Eder, J.; Feifel, R.; Hersperger, R.; Janser, P.; Revesz, L.; Zerwes, H.G.; Schlapbach, A.: Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg. Med. Chem. Lett., 16, 108–112 (2006)

    Article  PubMed  CAS  Google Scholar 

  26. Molestina, R.E.; Sinai, A.P.: Detection of a novel parasite kinase activity at the Toxoplasma gondii parasitophorous vacuole membrane capable of phosphorylating host IkBa. Cell. Microbiol., 7, 351–362 (2005)

    Article  PubMed  CAS  Google Scholar 

  27. Burke, J.R.: Targeting IkB kinase for the treatment of inflammatory and other disorders. Curr. Opin. Drug Discov. Devel., 6, 720–728 (2003)

    PubMed  CAS  Google Scholar 

  28. Ohazama, A.; Hu, Y.; Schmidt-Ullrich, R.; Cao, Y.; Scheidereit, C.; Karin, M.; Sharpe, P.T.: A dual role for Ikkα in tooth development. Dev. Cell, 6, 219–227 (2004)

    Article  PubMed  CAS  Google Scholar 

  29. Carter, R.S.; Pennington, K.N.; Ungurait, B.J.; Ballard, D.W.: In vivo identification of inducible phosphoacceptors in the IKKγ/NEMO subunit of human IκB kinase. J. Biol. Chem., 278, 19642–19648 (2003)

    Article  PubMed  CAS  Google Scholar 

  30. Sakurai, H.; Suzuki, S.; Kawasaki, N.; Nakano, H.; Okazaki, T.; Chino, A.; Doi, T.; Saiki, I.: Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J. Biol. Chem., 278, 36916–36923 (2003)

    Article  PubMed  CAS  Google Scholar 

  31. Tang, E.D.; Wang, C.Y.; Xiong, Y.; Guan, K.L.: A role for NF-κB essential modifier/IκB kinase-γ (NEMO/IKKγ) ubiquitination in the activation of the IκB kinase complex by tumor necrosis factor-α. J. Biol. Chem., 278, 37297–37305 (2003)

    Article  PubMed  CAS  Google Scholar 

  32. Verma, U.N.; Yamamoto, Y.; Prajapati, S.; Gaynor, R.B.: Nuclear role of IκB kinase-γ/NF-κB essential modulator (IKK γ/NEMO) in NF-κB-dependent gene expression. J. Biol. Chem., 279, 3509–3515 (2004)

    Article  PubMed  CAS  Google Scholar 

  33. Lebowitz, J.; Edinger, R.S.; An, B.; Perry, C.J.; Onate, S.; Kleyman, T.R.; Johnson, J.P.: IκB kinase-β (IKKβ) modulation of epithelial sodium channel activity. J. Biol. Chem., 279, 41985–41990 (2004)

    Article  PubMed  CAS  Google Scholar 

  34. Takada, Y.; Kobayashi, Y.; Aggarwal, B.B.: Evodiamine abolishes constitutive and inducible NF-κB activation by inhibiting IκBα kinase Activation, Thereby Suppressing NF-κB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. J. Biol. Chem., 280, 17203–17212 (2005)

    Article  PubMed  CAS  Google Scholar 

  35. Carter, R.S.; Pennington, K.N.; Arrate, P.; Oltz, E.M.; Ballard, D.W.: Site-specific monoubiquitination of IκB kinase IKKβ regulates its phosphorylation and persistent activation. J. Biol. Chem., 280, 43272–43279 (2005)

    Article  PubMed  CAS  Google Scholar 

  36. Wang, L.C.; Okitsu, C.Y.; Zandi, E.: Tumor necrosis factor α-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. J. Biol. Chem., 280, 7634–7644 (2005)

    Article  PubMed  CAS  Google Scholar 

  37. Molestina, R.E.; Sinai, A.P.: Host and parasite-derived IKK activities direct distinct temporal phases of NF-κB activation and target gene expression following Toxoplasma gondii infection. J. Cell Sci., 118, 5785–5796 (2005)

    Article  PubMed  CAS  Google Scholar 

  38. Luo, J.L.; Kamata, H.; Karin, M.: IKK/NF-κB signaling: balancing life and death — a new approach to cancer therapy. J. Clin. Invest., 115, 2625–2632 (2005)

    Article  PubMed  CAS  Google Scholar 

  39. Ruocco, M.G.; Maeda, S.; Park, J.M.; Lawrence, T.; Hsu, L.C.; Cao, Y.; Schett, G.; Wagner, E.F.; Karin, M.: IκB kinase IKKβ, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med., 201, 1677–1687 (2005)

    Article  PubMed  CAS  Google Scholar 

  40. Piccolella, E.; Spadaro, F.; Ramoni, C.; Marinari, B.; Costanzo, A.; Levrero, M.; Thomson, L.; Abraham, R.T.; Tuosto, L.: Vav-1 and the IKKα subunit of IκB kinase functionally associate to induce NF-κB activation in response to CD28 engagement. J. Immunol., 170, 2895–2903 (2003)

    PubMed  CAS  Google Scholar 

  41. Li, Z.W.; Omori, S.A.; Labuda, T.; Karin, M.; Rickert, R.C.: IKKβ is required for peripheral B cell survival and proliferation. J. Immunol., 170, 4630–4637 (2003)

    PubMed  CAS  Google Scholar 

  42. Yang, F.; Tang, E.; Guan, K.; Wang, C.Y.: IKKβ plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J. Immunol., 170, 5630–5635 (2003)

    PubMed  CAS  Google Scholar 

  43. Tegeder, I.; Niederberger, E.; Schmidt, R.; Kunz, S.; Guehring, H.; Ritzeler, O.; Michaelis, M.; Geisslinger, G.: Specific inhibition of IκB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. J. Neurosci., 24, 1637–1645 (2004)

    Article  PubMed  CAS  Google Scholar 

  44. Yoon, J.W.; Kang, J.K.; Lee, K.R.; Lee, H.W.; Han, J.W.; Seo, D.W.; Kim, Y.K.: β-Carboline alkaloid suppresses NF-κB transcriptional activity through inhibition of IKK signaling pathway. J. Toxicol. Environ. Health, 68, 2005–2017 (2005)

    Article  CAS  Google Scholar 

  45. Caposio, P.; Dreano, M.; Garotta, G.; Gribaudo, G.; Landolfo, S.: Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication. J. Virol., 78, 3190–3195 (2004)

    Article  PubMed  CAS  Google Scholar 

  46. Tegethoff, S.; Behlke, J.; Scheidereit, C.: Tetrameric oligomerization of IκB kinase γ (IKKγ) is obligatory for IKK complex activity and NF-κB activation. Mol. Cell. Biol., 23, 2029–2041 (2003)

    Article  PubMed  CAS  Google Scholar 

  47. Fitzgerald, K.A.; McWhirter, S.M.; Faia, K.L.; Rowe, D.C.; Latz, E.; Golenbock, D.T.; Coyle, A.J.; Liao, S.M.; Maniatis, T.: IKKε and TBK1 are essential components of the IRFκ signaling pathway. Nat. Immunol., 4, 491–496 (2003)

    Article  PubMed  CAS  Google Scholar 

  48. Chen, L.W.; Egan, L.; Li, Z.W.; Greten, F.R.; Kagnoff, M.F.; Karin, M.: The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat. Med., 9, 575–581 (2003)

    Article  PubMed  CAS  Google Scholar 

  49. Gross, S.; Piwnica-Worms, D.: Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat. Methods, 2, 607–614 (2005)

    Article  PubMed  CAS  Google Scholar 

  50. Yamamoto, Y.; Verma, U.N.; Prajapati, S.; Kwak, Y.T.; Gaynor, R.B.: Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression. Nature, 423, 655–659 (2003)

    Article  PubMed  CAS  Google Scholar 

  51. Lawrence, T.; Bebien, M.; Liu, G.Y.; Nizet, V.; Karin, M.: IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation. Nature, 434, 1138–1143 (2005)

    Article  PubMed  CAS  Google Scholar 

  52. Werner, S.L.; Barken, D.; Hoffmann, A.: Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science, 309, 1857–1861 (2005)

    Article  PubMed  CAS  Google Scholar 

  53. Yamamoto, Y.; Gaynor, R.B.: IkB kinases: key regulators of the NF-κB pathway. Trends Biochem. Sci., 29, 72–79 (2004)

    Article  PubMed  CAS  Google Scholar 

  54. Gloire, G.; Dejardin, E.; Piette, J.: Extending the nuclear roles of IκB kinase subunits. Biochem. Pharmacol., 72, 1081–1089 (2006)

    Article  PubMed  CAS  Google Scholar 

  55. Byun, M.S.; Choi, J.; Jue, D.M.: Cysteine-179 of IκB kinase β plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines. Exp. Mol. Med., 38, 546–552 (2006)

    PubMed  CAS  Google Scholar 

  56. Aleksic, T.; Baumann, B.; Wagner, M.; Adler, G.; Wirth, T.; Weber, C.K.: Cellular immune reaction in the pancreas is induced by constitutively active IκB kinase-2. Gut, 56, 227–236 (2007)

    Article  PubMed  CAS  Google Scholar 

  57. Wietek, C.; Cleaver, C.S.; Ludbrook, V.; Wilde, J.; White, J.; Bell, D.J.; Lee, M.; Dickson, M.; Ray, K.P.; ONeill, L.A.: IκB kinase e interacts with p52 and promotes transactivation via p65. J. Biol. Chem., 281, 34973–34981 (2006)

    Article  PubMed  Google Scholar 

  58. Furuya, K.; Ozaki, T.; Hanamoto, T.; Hosoda, M.; Hayashi, S.; Barker, P.A.; Takano, K.; Matsumoto, M.; Nakagawara, A.: Stabilization of p73 by nuclear IκB kinase-α mediates cisplatin-induced apoptosis. J. Biol. Chem., 282, 18365–18378 (2007)

    Article  PubMed  CAS  Google Scholar 

  59. Peng, Z.; Peng, L.; Fan, Y.; Zandi, E.; Shertzer, H.G.; Xia, Y.: A critical role for IκB kinase β in metallothionein-1 expression and protection against arsenic toxicity. J. Biol. Chem., 282, 21487–21496 (2007)

    Article  PubMed  CAS  Google Scholar 

  60. Kinoshita, D.; Hirota, F.; Kaisho, T.; Kasai, M.; Izumi, K.; Bando, Y.; Mouri, Y.; Matsushima, A.; Niki, S.; Han, H.; Oshikawa, K.; Kuroda, N.; Maegawa, M.; Irahara, M.; Takeda, K.; Akira, S.; Matsumoto, M.: Essential role of IκB kinase a in thymic organogenesis required for the establishment of selftolerance. J. Immunol., 176, 3995–4002 (2006)

    PubMed  CAS  Google Scholar 

  61. Bibeau-Poirier, A.; Gravel, S.P.; Clement, J.F.; Rolland, S.; Rodier, G.; Coulombe, P.; Hiscott, J.; Grandvaux, N.; Meloche, S.; Servant, M.J.: Involvement of the IκB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J. Immunol., 177, 5059–5067 (2006)

    PubMed  CAS  Google Scholar 

  62. Ha, U.; Lim, J.H.; Jono, H.; Koga, T.; Srivastava, A.; Malley, R.; Pages, G.; Pouyssegur, J.; Li, J.D.: A novel role for IκB kinase (IKK) α and IKKβ in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J. Immunol., 178, 1736–1747 (2007)

    PubMed  CAS  Google Scholar 

  63. Ahn, K.S.; Sethi, G.; Aggarwal, B.B.: Simvastatin potentiates TNF-α-induced apoptosis through the down-regulation of NF-κB-dependent antiapoptotic gene products: role of IkBa kinase and TGF-β-activated kinase-1. J. Immunol., 178, 2507–2516 (2007)

    PubMed  CAS  Google Scholar 

  64. Hansberger, M.W.; Campbell, J.A.; Danthi, P.; Arrate, P.; Pennington, K.N.; Marcu, K.B.; Ballard, D.W.; Dermody, T.S.: IκB kinase subunits α and γ are required for activation of NF-κB and induction of apoptosis by mammalian reovirus. J. Virol., 81, 1360–1371 (2007)

    Article  PubMed  CAS  Google Scholar 

  65. Wegener, E.; Oeckinghaus, A.; Papadopoulou, N.; Lavitas, L.; Schmidt-Supprian, M.; Ferch, U.; Mak, T.W.; Ruland, J.; Heissmeyer, V.; Krappmann, D.: Essential role for IκB kinase β in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol. Cell, 23, 13–23 (2006)

    Article  PubMed  CAS  Google Scholar 

  66. Edwards, M.R.; Hewson, C.A.; Laza-Stanca, V.; Lau, H.T.; Mukaida, N.; Hershenson, M.B.; Johnston, S.L.: Protein kinase R, IκB kinase-β and NF-κB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells. Mol. Immunol., 44, 1587–1597 (2007)

    Article  PubMed  CAS  Google Scholar 

  67. Hoshino, K.; Sugiyama, T.; Matsumoto, M.; Tanaka, T.; Saito, M.; Hemmi, H.; Ohara, O.; Akira, S.; Kaisho, T.: IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature, 440, 949–953 (2006)

    Article  PubMed  CAS  Google Scholar 

  68. Lubin, F.D.; Sweatt, J.D.: The IκB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron, 55, 942–957 (2007)

    Article  PubMed  CAS  Google Scholar 

  69. Cummins, E.P.; Berra, E.; Comerford, K.M.; Ginouves, A.; Fitzgerald, K.T.; Seeballuck, F.; Godson, C.; Nielsen, J.E.; Moynagh, P.; Pouyssegur, J.; Taylor, C.T.: Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity. Proc. Natl. Acad. Sci. USA, 103, 18154–18159 (2006)

    Article  PubMed  CAS  Google Scholar 

  70. Cao, Y.; Luo, J.L.; Karin, M.: IκB kinase a kinase activity is required for selfrenewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc. Natl. Acad. Sci. USA, 104, 15852–15857 (2007)

    Article  PubMed  Google Scholar 

  71. Lobry, C.; Lopez, T.; Israel, A.; Weil, R.: Negative feedback loop in T cell activation through IκB kinase-induced phosphorylation and degradation of Bcl10. Proc. Natl. Acad. Sci. USA, 104, 908–913 (2007)

    Article  PubMed  CAS  Google Scholar 

  72. Tenoever, B.R.; Ng, S.L.; Chua, M.A.; McWhirter, S.M.; Garcia-Sastre, A.; Maniatis, T.: Multiple functions of the IKK-related kinase IKKε in interferon-mediated antiviral immunity. Science, 315, 1274–1278 (2007)

    Article  PubMed  CAS  Google Scholar 

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(2009). IκB kinase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 Transferases. Springer Handbook of Enzymes, vol S3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85699-3_10

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