Skip to main content

Caffeine synthase

  • Chapter
  • 575 Accesses

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S2))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Koshiishi, C.; Kato, A.; Yama, S.; Crozier, A.; Ashihara, H.: A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-l-methionine cycle. FEBS Lett., 499, 50–54 (2001)

    Article  CAS  PubMed  Google Scholar 

  2. McCarthy, A.A.; Biget, L.; Lin, C.; Petiard, V.; Tanksley, S.D.; McCarthy, J.G.: Cloning, expression, crystallization and preliminary x-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta). Acta Crystallogr. Sect. F, F63, 304–307 (2007)

    Article  CAS  Google Scholar 

  3. Mizuno, K.; Okuda, A.; Kato, M.; Yoneyama, N.; Tanaka, H.; Ashihara, H.; Fujimura, T.: Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.). FEBS Lett., 534, 75–81 (2003)

    Article  CAS  PubMed  Google Scholar 

  4. Ogawa, M.; Herai, Y.; Koizumi, N.; Kusano, T.; Sano, H.: 7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties. J. Biol. Chem., 276, 8213–8218 (2001)

    Article  CAS  PubMed  Google Scholar 

  5. Kato, M.; Mizuno, K.; Crozier, A.; Fujimura, T.; Ashihara, H.: Caffeine synthase gene from tea leaves. Nature, 406, 956–957 (2000)

    Article  CAS  PubMed  Google Scholar 

  6. Roberts, M.F.; Waller, G.R.: N-methyltransferases and 7-methyl-N9-nucleoside hydrolase activity in Coffea arabica and the biosynthesis of caffeine. Phytochemistry, 18, 451–455 (1979)

    Article  CAS  Google Scholar 

  7. Waldhauser, S.S.M.; Gillies, F.M.; Crozier, A.; Baumann, T.W.: Separation of the N-7 methyltransferase, the key enzyme in caffeine biosynthesis. Phytochemistry, 45, 1407–1414 (1997)

    Article  CAS  Google Scholar 

  8. Ogita, S.; Uefuji, H.; Morimoto, M.; Sano, H.: Application of RNAi to confirm theobromine as the major intermediate for caffeine biosynthesis in coffee plants with potential for construction of decaffeinated varieties. Plant Mol. Biol., 54, 931–941 (2004)

    Article  CAS  PubMed  Google Scholar 

  9. Uefuji, H.; Tatsumi, Y.; Morimoto, M.; Kaothien-Nakayama, P.; Ogita, S.; Sano, H.: Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltranferases and its potential as a pest repellant. Plant Mol. Biol., 59, 221–227 (2005)

    Article  CAS  PubMed  Google Scholar 

  10. Kato, M.; Mizuno, K.; Fujimura, T.; Iwama, M.; Irie, M.; Crozier, A.; Ashihara, H.: Purification and characterization of caffeine synthase from tea leaves. Plant Physiol., 120, 579–586 (1999)

    Article  CAS  PubMed  Google Scholar 

  11. Uefuji, H.; Ogita, S.; Yamaguchi, Y.; Koizumi, N.; Sano, H.: Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants. Plant Physiol., 132, 372–380 (2003)

    Article  CAS  PubMed  Google Scholar 

  12. McCarthy, A.A.; McCarthy, J.G.: The structure of two N-methyltransferases from the caffeine biosynthetic pathway. Plant Physiol., 144, 879–889 (2007)

    Article  CAS  PubMed  Google Scholar 

  13. Koshiro, Y.; Zheng, X.-Q.; Wang, M.-L.; Nagai, C.; Ashihara, H.: Changes in content and biosynthetic activity of caffeine and rigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits. Plant Sci., 171, 242–250 (2006)

    Article  CAS  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2009). Caffeine synthase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 Transferases. Springer Handbook of Enzymes, vol S2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85697-9_8

Download citation

Publish with us

Policies and ethics