The Avogadro challenge is to reconstruct and analyze macroscopic behavior based on microscopic dynamics with the help of computer. It now reaches to the stage to reproduce transport phenomena like heat and electric conduction, and Newtonian fluid. It's applications have started from nanoscopic to mesoscopic sciences and technologies
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Ito, N. (2009). The Avogadro Challenge. In: Landau, D.P., Lewis, S.P., Schöttler, H.B. (eds) Computer Simulation Studies in Condensed-Matter Physics XIX. Springer Proceedings in Physics, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85625-2_7
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