Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Schweitzer D, Leistritz L, Hammer M et al (1995) Calibration-free measurement of the oxygen saturation in retinal vessels of men. Ophthalmic Technol V, SPIE 2393: 210–218
Feke GT (2006) Laser Doppler instrumentation for the measurement of retinal blood flow: theory and practice. Bull Soc Belge Ophtalmol 302:171–184
Leitgeb RA, Schmetterer L, Hitzenberger CK et al (2004) Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography. Opt Lett 29(2):171–173
Beach JM, Schwenzer KJ, Srinivas S et al (1999) Oximetry of retinal vessels by dual-wavelength imaging: calibration and influence of pigmentation. J Appl Physiol 86(2): 748–758
Schweitzer D, Hammer M, Kraft J et al (1999) In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers. IEEE Trans Biomed Eng 46 (12): 1454–1465
Schweitzer D, Lasch A, van der Vorst S et al (2007) Änderung der retinalen Sauerstoffsättigung bei Gesunden und in frühen Stadien der diabetische Retinopathie nach Atmung von 100% Sauerstoff. Klin Monatsbl Augenheilkd 224:402–410
Stryer L (1991) Biochemie. Spectrum Akademischer, Verlag GmbH Heidelberg
Boettner EA, Wolter JR (1962) Transmission of the ocular media. Invest Ophthalmol 1:776–783
La Schiazza O, Bille JF (2008) High-speed two-photon excited autofluorescence imaging of ex vivo human retinal pigment epithelial cells toward age-related macular degeneration diagnostic. J Biomed Opt 13(6):064008
American National Standard for the safe use of laser ANSI Z 136.1–2000 (2000) Laser Institute of America, Orlando, FL
Schweitzer D, Schenke S, Hammer M et al (2007) Towards metabolic mapping of the human retina. Microsc Res Tech 70:410–419
Sionkowska A, Skopinska J, Wisniewski M et al (2007) Spectroscopic studies into the influence of UV radiation on elastin in the presence of collagen. J Photochem Photobiol B Biol 86:186–191
Skala MC, Riching KM, Gendron-Fitzpatrick A et al (2007) In vivo multiphoton microscopy of metabolic oxidation-reduction states and fluorescence lifetimes in normal and pre-cancerous epithelia. Proc Natl Acad Sci U S A 104(49): 19494–19499
Yagi K, Tanaka F, Nakashima N et al (1983) Picosecond laser fluorometry of FAD of D-amino acid oxidase-benzoate complex. J Biol Chem 258(6):3799–3802
Nakashima N, Yoshihara K, Tanaka F et al (1980) Picosecond fluorescence lifetime of the coenzyme of D-amino acid oxidase. J Biol Chem 255 (11):5261–5263
König K, Riemann I (2003) High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution. J Biomed Opt 8 (3): 432–439
Schneckenburger H, Wagner M, Weber P et al (2004) Autofluorescence lifetime imaging of cultivated cells using a UV picosecond laser diode. J Fluoresc 14 (5): 649–654
Wu Y, Zheng W, Qu J (2006) Sensing cell metabolism by time-resolved autofluorescence. Opt Lett 31(21): 3122–3124
Schweitzer D, Jentsch S, Schenke S et al (2007) Spectral and time-resolved studies on ocular structures. In: Schweitzer D, Fitzmaurice M (eds) Diagnostic optical spectroscopy in biomedicine IV. Proceedings of the SPIE, 6628,pp 662807-1–662807-12
Schweitzer D, Kolb A, Hammer M et al (2000) Tau mapping of the autofluorescence of the human ocular fundus. SPIE 4164:79–89
Goldenberg-Cohen N, Dadon S, Avraham BCR et al (2008) Molecular and histological changes following central retinal artery occlusion in a mouse model. Exp Eye Res 87: 327–333
Lakowicz JR (2007) Principles of fluorescence spectroscopy, 3rd edn. Kluwer, Academic, Plenum, New York
Becker W (2005) Advanced time-correlated single photon counting techniques. Springer Series in Chemical Physics 81. Springer, Berlin
Schweitzer D, Hammer M, Schweitzer F et al (2004) In vivo measurement of time-resolved autofluorescence at the human fundus. J Biomed Opt 9(6)1214–1222
Schweitzer D, Quick S, Schenke S et al (2009) Vergleich von Parametern der zeitaufgelösten Autofluoreszenz bei Gesunden und Patienten mit früher AMD. Ophthalmologe 9(6):714–722
AREDS Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8. Arch Ophthalmol 119(10):1417–1436
Eldred GE, Katz ML (1988) Fluorophores of the human pigment epithelium: separation and spectral characterization. Exp Eye Res 47:71–86
Schweitzer D (2010) Quantifying fundus autofluorescence. In: Lois N, Forrester JV (eds) Fundus autofluorescence. Lippincott Williams & Wilkins, Philadelphia
Bindewald A, Bird AC, Dandekar SS et al (2005) Classification of fundus autofluorescence patterns in early age-related macular diseases. Invest Ophthalmol Vis Sci 46:3309–3314
Birol G, Budzynski E, Wangsa-Wirawan ND et al (2005) Retinal arterial occlusion leads to acidosis in the cat. Exp Eye Res 80:527–533
Wakita M, Nishimura G, Tamura M (1995) Some characteristics of the fluorescence lifetime of reduced pyridine nucleotides in isolated mitochondria, isolated hepatocytes, and perfused rat liver in situ. J Biochem 118:1151–1160
Wang HW, Gukassyan V, Chen CT et al (2008) Differentiation of apoptosis from necrosis by dynamic changes of reduced nicotinamide adenine dinucleotide fluorescence lifetime in live cells. J Biomed Opt 13(5):054011
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schweitzer, D. (2010). Metabolic Mapping. In: Holz, F.G., Spaide, R. (eds) Medical Retina. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85540-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-540-85540-8_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-85539-2
Online ISBN: 978-3-540-85540-8
eBook Packages: MedicineMedicine (R0)