Skip to main content
SpringerLink
Log in

Kutane lymphoproliferative und hämatopoietische Erkrankungen

  • Chapter
  • First Online:
Pathologie

  • 3598 Accesses

Zusammenfassung

Kutane Manifestationen sind bei hämatologischen Erkrankungen häufig. Darüber hinaus sind inzwischen viele primär kutane Lymphoproliferationen und Lymphomentitäten des T-, NK- und der dendritischen Vorläuferzellpopulationen definiert. Das Spektrum hat sich seit der letzten Überarbeitung der WHO erheblich erweitert und spezifiziert. Im vorliegenden Kapitel sind alle nach der neuen WHO klassifizierten lymphatischen Neoplasien behandelt und nach diagnostischen klinischen und pathologischen Strategien und Differenzialdiagnosen dargestellt. Damit stellt es für alle klinisch tätigen Dermatologen und Pathologen eine aktuelle und relevante und nach funktionellen Kriterien geordnete Übersicht dar.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  1. Baefverstedt B (1944) Ueber lymphadenosis benigna cutis. Eine klinische pathologisch-anatomische Studie. Acta Derm Venereol 24(Suppl XI):1–102

    Google Scholar 

  2. Baldassano MF, Bailey EM, Ferry JA et al (1999) Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophenotypic features. Am J Surg Pathol 23:88–96

    Article  CAS  PubMed  Google Scholar 

  3. Beaty MW, Toro J, Sorbara L et al (2001) Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. Am J Surg Pathol 25:1111–1120

    Article  CAS  PubMed  Google Scholar 

  4. Bekkenk MW, Geelen FA, Van Voorst Vader PC et al (2000) Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood 95:3653–3661

    CAS  PubMed  Google Scholar 

  5. Bekkenk MW, Vermeer MH, Jansen PM et al (2003) Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood 102:2213–2219

    Article  CAS  PubMed  Google Scholar 

  6. Beljaards RC, Meijer CJ, Van Der Putte SC et al (1994) Primary cutaneous T-cell lymphoma: clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma. J Pathol 172:53–60

    Article  CAS  PubMed  Google Scholar 

  7. Beltraminelli H, Leinweber B, Kerl H et al (2009) Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases. Am J Dermatopathol 31:317–322

    Article  PubMed  Google Scholar 

  8. Benner MF, Willemze R (2009) Applicability and prognostic value of the new TNM classification system in 135 patients with primary cutaneous anaplastic large cell lymphoma. Arch Dermatol 145:1399–1404

    Article  PubMed  Google Scholar 

  9. Berti E, Recalcati S, Girgenti V et al (2010) Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization. Blood 116:165–170

    Article  CAS  PubMed  Google Scholar 

  10. Berti E, Tomasini D, Vermeer MH et al (1999) Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol 155:483–492

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Brenner I, Roth S, Puppe B et al (2013) Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression. Mod Pathol 26:1568–1576

    Article  CAS  PubMed  Google Scholar 

  12. Buechner SA, Li CY, Su WP (1985) Leukemia cutis. A histopathologic study of 42 cases. Am J Dermatopathol 7:109–119

    Article  CAS  PubMed  Google Scholar 

  13. Buechner SA, Winkelmann RK (1983) Sezary syndrome. A clinicopathologic study of 39 cases. Arch Dermatol 119:979–986

    Article  CAS  PubMed  Google Scholar 

  14. Burg G, Kempf W, Kazakov DV et al (2003) Pyogenic lymphoma of the skin: a peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large-cell lymphoma. Clinicopathological study of four cases and review of the literature. Br J Dermatol 148:580–586

    Article  CAS  PubMed  Google Scholar 

  15. Campbell JJ, Clark RA, Watanabe R et al (2010) Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 116:767–771

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Cerroni L, Kerl H (2001) Primary cutaneous follicle center cell lymphoma. Leuk Lymphoma 42:891–900

    Article  CAS  PubMed  Google Scholar 

  17. Cerroni L, Massone C, Kutzner H et al (2008) Intravascular large T-cell or NK-cell lymphoma: a rare variant of intravascular large cell lymphoma with frequent cytotoxic phenotype and association with Epstein-Barr virus infection. Am J Surg Pathol 32:891–898

    Article  PubMed  Google Scholar 

  18. Cerroni L, Signoretti S, Hofler G et al (1997) Primary cutaneous marginal zone B-cell lymphoma: a recently described entity of low-grade malignant cutaneous B-cell lymphoma [see comments. Am J Surg Pathol 21:1307–1315

    Article  CAS  PubMed  Google Scholar 

  19. Cerroni L, Zenahlik P, Hofler G et al (1996) Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients. Am J Surg Pathol 20:1000–1010

    Article  CAS  PubMed  Google Scholar 

  20. Cerroni L, Zochling N, Putz B et al (1997) Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. J Cutan Pathol 24:457–461

    Article  CAS  PubMed  Google Scholar 

  21. Child FJ, Jones RR, Woolford AJ et al (2001) Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma. Br J Dermatol 144:735–744

    Article  CAS  PubMed  Google Scholar 

  22. Chimenti S, Fink-Puches R, Peris K et al (1999) Cutaneous involvement in lymphoblastic lymphoma. J Cutan Pathol 26:379–385

    Article  CAS  PubMed  Google Scholar 

  23. Colli C, Leinweber B, Mullegger R et al (2004) Borrelia burgdorferi-associated lymphocytoma cutis: clinicopathologic, immunophenotypic, and molecular study of 106 cases. J Cutan Pathol 31:232–240

    Article  PubMed  Google Scholar 

  24. Cota C, Vale E, Viana I et al (2010) Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients. Am J Surg Pathol 34:75–87

    Article  PubMed  Google Scholar 

  25. Decoteau JF, Butmarc JR, Kinney MC et al (1996) The t(2;5) chromosomal translocation is not a common feature of primary cutaneous CD30+ lymphoproliferative disorders: comparison with anaplastic large-cell lymphoma of nodal origin. Blood 87:3437–3441

    CAS  PubMed  Google Scholar 

  26. Dummer R, Cozzio A, Urosevic M (2006) Pathogenesis and therapy of cutaneous lymphomas--progress or impasse? Exp Dermatol 15:392–400

    Article  PubMed  Google Scholar 

  27. El Shabrawi-Caelen L, Kerl H, Cerroni L (2004) Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C. Arch Dermatol 140:441–447

    PubMed  Google Scholar 

  28. Ferreri AJ, Campo E, Seymour JF et al (2004) Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ’cutaneous variant’. Br J Haematol 127:173–183

    Article  PubMed  Google Scholar 

  29. Flaig MJ, Schuhmann K, Sander CA (2000) Impact of molecular analysis in the diagnosis of cutaneous lymphoid infiltrates. Semin Cutan Med Surg 19:87–90

    Article  CAS  PubMed  Google Scholar 

  30. Fried I, Artl M, Cota C et al (2014) Clinicopathologic and molecular features in cutaneous extranodal natural killer-/T-cell lymphoma, nasal type, with aggressive and indolent course. J Am Acad Dermatol 70:716–723

    Article  CAS  PubMed  Google Scholar 

  31. Garcia-Herrera A, Colomo L, Camos M et al (2008) Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol 26:3364–3371

    Article  PubMed  Google Scholar 

  32. Geerts ML, Busschots AM (1994) Mantle-cell lymphomas of the skin. Dermatol Clin 12:409–417

    Article  CAS  PubMed  Google Scholar 

  33. Geissinger E, Sadler P, Roth S et al (2010) Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica 95:1697–1704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Gellrich S, Rutz S, Golembowski S et al (2001) Primary cutaneous follicle center cell lymphomas and large B cell lymphomas of the leg descend from germinal center cells. A single cell polymerase chain reaction analysis. J Invest Dermatol 117:1512–1520

    Article  CAS  PubMed  Google Scholar 

  35. Golling P, Cozzio A, Dummer R et al (2008) Primary cutaneous B-cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. Leuk Lymphoma 49:1094–1103

    Article  PubMed  Google Scholar 

  36. Goodlad JR, Krajewski AS, Batstone PJ et al (2002) Primary cutaneous follicular lymphoma: a clinicopathologic and molecular study of 16 cases in support of a distinct entity. Am J Surg Pathol 26:733–741

    Article  PubMed  Google Scholar 

  37. Guitart J, Weisenburger DD, Subtil A et al (2012) Cutaneous gammadelta T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas. Am J Surg Pathol 36:1656–1665

    Article  PubMed  Google Scholar 

  38. Haghighi B, Smoller BR, Leboit PE et al (2000) Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopathologic study. Mod Pathol 13:502–510

    Article  CAS  PubMed  Google Scholar 

  39. Hembury TA, Lee B, Gascoyne RD et al (2002) Primary cutaneous diffuse large B-cell lymphoma: a clinicopathologic study of 15 cases. Am J Clin Pathol 117:574–580

    Article  PubMed  Google Scholar 

  40. Hoefnagel JJ, Vermeer MH, Jansen PM et al (2003) Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle centre cell origin and differential diagnostic significance. Br J Dermatol 149:1183–1191

    Article  CAS  PubMed  Google Scholar 

  41. Hoefnagel JJ, Vermeer MH, Jansen PM et al (2005) Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases. Arch Dermatol 141:1139–1145

    Article  CAS  PubMed  Google Scholar 

  42. Hofbauer GF, Kessler B, Kempf W et al (2001) Multilesional primary cutaneous diffuse large B-cell lymphoma responsive to antibiotic treatment. Dermatology 203:168–170

    Article  CAS  PubMed  Google Scholar 

  43. Hoque SR, Child FJ, Whittaker SJ et al (2003) Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol 148:516–525

    Article  CAS  PubMed  Google Scholar 

  44. Iwatsuki K, Ohtsuka M, Akiba H et al (1999) Atypical hydroa vacciniforme in childhood: from a smoldering stage to Epstein-Barr virus-associated lymphoid malignancy. J Am Acad Dermatol 40:283–284

    Article  CAS  PubMed  Google Scholar 

  45. Jawed SI, Myskowski PL, Horwitz S et al (2014) Primary cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am Acad Dermatol 70:205e201–205e216 (quiz 221–202)

    Article  Google Scholar 

  46. Joly P, Vasseur E, Esteve E et al (1995) Primary cutaneous medium and large cell lymphomas other than mycosis fungoides. An immunohistological and follow-up study on 54 cases. French Study Group for Cutaneous Lymphomas. Br J Dermatol 132:506–512

    Article  CAS  PubMed  Google Scholar 

  47. Kaddu S, Zenahlik P, Beham-Schmid C et al (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40:966–978

    Article  CAS  PubMed  Google Scholar 

  48. Kadin ME, Levi E, Kempf W (2001) Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by TGF-beta and CD30 ligand. Ann N Y Acad Sci 941:59–68

    Article  CAS  PubMed  Google Scholar 

  49. Karai LJ, Kadin ME, Hsi ED et al (2013) Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis. Am J Surg Pathol 37:1173–1181

    Article  PubMed  Google Scholar 

  50. Kazakov DV, Burg G, Dummer R et al (2002) Cutaneous lymphomas and pseudolymphomas: newly described entities. Recent Results Cancer Res 160:283–293

    Article  PubMed  Google Scholar 

  51. Kazakov DV, Burg G, Kempf W (2004) Clinicopathological spectrum of mycosis fungoides. J Eur Acad Dermatol Venereol 18:397–415

    Article  CAS  PubMed  Google Scholar 

  52. Kempf W (2006) CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. J Cutan Pathol 33(Suppl 1):58–70

    Article  PubMed  Google Scholar 

  53. Kempf W (2014) Cutaneous CD30-positive lymphoproliferative disorders. Surg Pathol Clin 7:203–228

    Article  PubMed  Google Scholar 

  54. Kempf W, Denisjuk N, Kerl K et al (2012) Primary cutaneous B-cell lymphomas. J Dtsch Dermatol Ges 10:12–22 (quiz 23)

    PubMed  Google Scholar 

  55. Kempf W, Kadin ME, Dvorak AM et al (2003) Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin. Carcinogenesis 24:301–306

    Article  CAS  PubMed  Google Scholar 

  56. Kempf W, Kazakov DV, Cozzio A et al (2013) Primary cutaneous CD8(+) small- to medium-sized lymphoproliferative disorder in extrafacial sites: clinicopathologic features and concept on their classification. Am J Dermatopathol 35:159–166

    Article  PubMed  Google Scholar 

  57. Kempf W, Kazakov DV, Kerl K (2014) Cutaneous lymphomas: an update. Part 1: T-cell and natural killer/t-cell lymphomas and related conditions. Am J Dermatopathol 36:105–123

    Article  PubMed  Google Scholar 

  58. Kempf W, Kazakov DV, Mitteldorf C (2014) Cutaneous lymphomas: an update. Part 2: B-cell lymphomas and related conditions. Am J Dermatopathol 36:197–208 (quiz 209–110)

    Article  PubMed  Google Scholar 

  59. Kempf W, Kazakov DV, Scharer L et al (2013) Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas. Am J Surg Pathol 37:1–13

    Article  PubMed  Google Scholar 

  60. Kempf W, Levi E, Kamarashev J et al (2002) Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. J Cutan Pathol 29:295–300

    Article  PubMed  Google Scholar 

  61. Kempf W, Ostheeren-Michaelis S, Paulli M et al (2008) Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC). Arch Dermatol 144:1609–1617

    Article  PubMed  Google Scholar 

  62. Kempf W, Pfaltz K, Vermeer MH et al (2011) EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood 118:4024–4035

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Kempf W, Rozati S, Kerl K et al (2012) Cutaneous peripheral T-cell lymphomas, unspecified/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas. G Ital Dermatol Venereol 147:553–562

    CAS  PubMed  Google Scholar 

  64. Kodama K, Massone C, Chott A et al (2005) Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. Blood 106:2491–2497

    Article  CAS  PubMed  Google Scholar 

  65. Kulow BF, Cualing H, Steele P et al (2002) Progression of cutaneous B-cell pseudolymphoma to cutaneous B-cell lymphoma. J Cutan Med Surg 6:519–528

    Article  PubMed  Google Scholar 

  66. Kumar S, Krenacs L, Medeiros J et al (1998) Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes. Hum Pathol 29:397–403

    Article  CAS  PubMed  Google Scholar 

  67. Kummer JA, Vermeer MH, Dukers D et al (1997) Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype. J Invest Dermatol 109:636–640

    Article  CAS  PubMed  Google Scholar 

  68. Leboit PE (1994) Granulomatous slack skin. Dermatol Clin 12:375–389

    Article  CAS  PubMed  Google Scholar 

  69. Lee WJ, Jung JM, Won CH et al (2014) Cutaneous extranodal natural killer/T-cell lymphoma: a comparative clinicohistopathologic and survival outcome analysis of 45 cases according to the primary tumor site. J Am Acad Dermatol 70:1002–1009

    Article  PubMed  Google Scholar 

  70. Lessin SR, Vowels BR, Rook AH (1994) Retroviruses and cutaneous T-cell lymphoma. Dermatol Clin 12:243–253

    Article  CAS  PubMed  Google Scholar 

  71. Lutzner MA, Jordan HW (1968) The ultrastructure of an abnormal cell in Sezary’s syndrome. Blood 31:719–726

    CAS  PubMed  Google Scholar 

  72. Macaulay WL (1968) Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant. Arch Dermatol 97:23–30

    Article  CAS  PubMed  Google Scholar 

  73. Marchetti MA, Pulitzer MP, Myskowski PL et al (2015) Cutaneous manifestations of human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: A single-center, retrospective study. J Am Acad Dermatol 72:293–301e292

    Article  PubMed  Google Scholar 

  74. Martel P, Laroche L, Courville P et al (2000) Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immunohistological, and molecular analysis. Arch Dermatol 136:881–886

    Article  CAS  PubMed  Google Scholar 

  75. Martinez-Escaname M, Zuriel D, Tee SI et al (2013) Cutaneous infiltrates of acute myelogenous leukemia simulating inflammatory dermatoses. Am J Dermatopathol 35:419–424

    Article  PubMed  Google Scholar 

  76. Massone C, Cerroni L (2014) Phenotypic variability in primary cutaneous anaplastic large T-cell lymphoma: a study on 35 patients. Am J Dermatopathol 36:153–157

    Article  PubMed  Google Scholar 

  77. Massone C, Crisman G, Kerl H et al (2008) The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality. Br J Dermatol 159:881–886

    Article  CAS  PubMed  Google Scholar 

  78. Massone C, El-Shabrawi-Caelen L, Kerl H et al (2008) The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants. J Cutan Pathol 35:46–53

    Article  PubMed  Google Scholar 

  79. Massone C, Fink-Puches R, Laimer M et al (2011) Miliary and agminated-type primary cutaneous follicle center lymphoma: report of 18 cases. J Am Acad Dermatol 65:749–755

    Article  PubMed  Google Scholar 

  80. Massone C, Kodama K, Kerl H et al (2005) Histopathologic features of early (patch) lesions of mycosis fungoides: a morphologic study on 745 biopsy specimens from 427 patients. Am J Surg Pathol 29:550–560

    Article  PubMed  Google Scholar 

  81. Michaelis S, Kazakov DV, Burg G et al (2006) Extracutaneous transformation into a high-grade lymphoma: a potential pitfall in the management of patients with Sezary syndrome. Int J Dermatol 45:277–279

    Article  PubMed  Google Scholar 

  82. Michaelis S, Kazakov DV, Schmid M et al (2003) Hepatitis C and G viruses in B-cell lymphomas of the skin. J Cutan Pathol 30:369–372

    Article  PubMed  Google Scholar 

  83. Moreau Cabarrot A, Bonafe JL, Gorguet B et al (1994) Papulose lymphomatoide et lymphome anaplasique a grandes cellules. Ann Dermatol Venereol 121:727–730

    CAS  PubMed  Google Scholar 

  84. Mraz Gernhard S, Natkunam Y, Hoppe RT et al (2001) Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: an increasingly recognized entity with an aggressive course. J Clin Oncol 19:2179–2188

    Article  CAS  PubMed  Google Scholar 

  85. Nikolaou VA, Papadavid E, Katsambas A et al (2009) Clinical characteristics and course of CD8+ cytotoxic variant of mycosis fungoides: a case series of seven patients. Br J Dermatol 161:826–830

    Article  CAS  PubMed  Google Scholar 

  86. Nofal A, Abdel-Mawla MY, Assaf M et al (2012) Primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma: Proposed diagnostic criteria and therapeutic evaluation. J Am Acad Dermatol 67:748–759

    Article  PubMed  Google Scholar 

  87. Olsen E, Vonderheid E, Pimpinelli N et al (2007) Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110:1713–1722

    Article  CAS  PubMed  Google Scholar 

  88. Palmedo G, Hantschke M, Rutten A et al (2007) Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma? Am J Dermatopathol 29:231–236

    Article  PubMed  Google Scholar 

  89. Paulli M, Berti E, Rosso R et al (1995) CD30/Ki-1-positive lymphoproliferative disorders of the skin – clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group. J Clin Oncol 13:1343–1354

    Article  CAS  PubMed  Google Scholar 

  90. Perniciaro C, Winkelmann RK, Daoud MS et al (1995) Malignant angioendotheliomatosis is an angiotropic intravascular lymphoma. Immunohistochemical, ultrastructural, and molecular genetics studies. Am J Dermatopathol 17:242–248

    Article  CAS  PubMed  Google Scholar 

  91. Petrella T, Bagot M, Willemze R et al (2005) Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review. Am J Clin Pathol 123:662–675

    Article  PubMed  Google Scholar 

  92. Petrella T, Maubec E, Cornillet-Lefebvre P et al (2007) Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphoma? Am J Surg Pathol 31:1887–1892

    Article  PubMed  Google Scholar 

  93. Pfaltz K, Kerl K, Palmedo G et al (2011) Clonality in sarcoidosis, granuloma annulare, and granulomatous mycosis fungoides. Am J Dermatopathol 33:659–662

    Article  PubMed  Google Scholar 

  94. Pimpinelli N, Santucci M, Bosi A et al (1989) Primary cutaneous follicular centre-cell lymphoma--a lymphoproliferative disease with favourable prognosis. Clin Exp Dermatol 14:12–19

    Article  CAS  PubMed  Google Scholar 

  95. Pincus LB, Leboit PE, Mccalmont TH et al (2009) Subcutaneous panniculitis-like T-cell lymphoma with overlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities? Am J Dermatopathol 31:520–526

    Article  PubMed  Google Scholar 

  96. Ploysangam T, Breneman DL, Mutasim DF (1998) Cutaneous pseudolymphomas. J Am Acad Dermatol 38:877–895

    Article  CAS  PubMed  Google Scholar 

  97. Poenitz N, Dippel E, Klemke CD et al (2003) Jessner’s lymphocytic infiltration of the skin: a CD8+ polyclonal reactive skin condition. Dermatology 207:276–284

    Article  CAS  PubMed  Google Scholar 

  98. Poszepczynska-Guigne E, Schiavon V, D’incan M et al (2004) CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. J Invest Dermatol 122:820–823

    Article  CAS  PubMed  Google Scholar 

  99. Pulitzer M, Myskowski PL, Horwitz SM et al (2014) Mycosis fungoides with large cell transformation: clinicopathological features and prognostic factors. Pathology 46:610–616

    Article  PubMed  Google Scholar 

  100. Ram-Wolff C, Martin-Garcia N, Bensussan A et al (2010) Histopathologic diagnosis of lymphomatous versus inflammatory erythroderma: a morphologic and phenotypic study on 47 skin biopsies. Am J Dermatopathol 32:755–763

    Article  PubMed  PubMed Central  Google Scholar 

  101. Robson A, Assaf C, Bagot M et al (2014) Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features report of an EORTC cutaneous Lymphoma task force workshop. Histopathology 67:425–441

    Article  Google Scholar 

  102. Rodriguez Pinilla SM, Roncador G, Rodriguez-Peralto JL et al (2009) Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers. Am J Surg Pathol 33:81–90

    Article  PubMed  Google Scholar 

  103. Rodriguez-Pinilla SM, Barrionuevo C, Garcia J et al (2010) EBV-associated cutaneous NK/T-cell lymphoma: review of a series of 14 cases from peru in children and young adults. Am J Surg Pathol 34:1773–1782

    Article  PubMed  Google Scholar 

  104. Roglin J, Boer A (2007) Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin. Br J Dermatol 157:16–25

    Article  CAS  PubMed  Google Scholar 

  105. Rongioletti F, De Lucchi S, Meyes D et al (2010) Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides-associated follicular mucinosis. J Cutan Pathol 37:15–19

    Article  PubMed  Google Scholar 

  106. Russell-Jones R, Whittaker S (2000) Sezary syndrome: diagnostic criteria and therapeutic options. Semin Cutan Med Surg 19:100–108

    CAS  PubMed  Google Scholar 

  107. Saggini A, Gulia A, Argenyi Z et al (2010) A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. Am J Surg Pathol 34:1168–1175

    Article  PubMed  Google Scholar 

  108. Sandberg Y, Van Gastel-Mol EJ, Verhaaf B et al (2005) BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics. J Mol Diagn 7:495–503

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Sander CA, Flaig MJ (1999) Morphologic spectrum of cutaneous B-cell lymphomas. Dermatol Clin 17:593–599

    Article  CAS  PubMed  Google Scholar 

  110. Sander CA, Medeiros LJ, Abruzzo LV et al (1991) Lymphoblastic lymphoma presenting in cutaneous sites. A clinicopathologic analysis of six cases. J Am Acad Dermatol 25:1023–1031

    Article  CAS  PubMed  Google Scholar 

  111. Santucci M, Pimpinelli N, Massi D et al (2003) Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer 97:610–627

    Article  PubMed  Google Scholar 

  112. Sen F, Medeiros LJ, Lu D et al (2002) Mantle cell lymphoma involving skin: cutaneous lesions may be the first manifestation of disease and tumors often have blastoid cytologic features. Am J Surg Pathol 26:1312–1318

    Article  PubMed  Google Scholar 

  113. Senff NJ, Hoefnagel JJ, Jansen PM et al (2007) Reclassification of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol 25:1581–1587

    Article  PubMed  Google Scholar 

  114. Senff NJ, Zoutman WH, Vermeer MH et al (2008) Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large b-cell lymphoma, leg type. J Invest Dermatol 129:1149–1155

    Article  CAS  PubMed  Google Scholar 

  115. Sentis HJ, Willemze R, Scheffer E (1986) Histopathologic studies in Sezary syndrome and erythrodermic mycosis fungoides: a comparison with benign forms of erythroderma. J Am Acad Dermatol 15:1217–1226

    Article  CAS  PubMed  Google Scholar 

  116. Servitje O, Estrach T, Pujol RM et al (2002) Primary cutaneous marginal zone B-cell lymphoma: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. Br J Dermatol 147:1147–1158

    Article  CAS  PubMed  Google Scholar 

  117. Servitje O, Muniesa C, Benavente Y et al (2013) Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients. J Am Acad Dermatol 69:357–365

    Article  PubMed  Google Scholar 

  118. Siegel R, Gartenhaus R, Kuzel T (2001) HTLV-I associated leukemia/lymphoma: epidemiology, biology, and treatment. Cancer Treat Res 104:75–88

    Article  CAS  PubMed  Google Scholar 

  119. Simon M, Flaig MJ, Kind P et al (2000) Large plaque parapsoriasis: clinical and genotypic correlations. J Cutan Pathol 27:57–60

    Article  CAS  PubMed  Google Scholar 

  120. Storz MN, Van De Rijn Kim M, Kim YH et al (2003) Gene expression profiles of cutaneous B cell lymphoma. J Invest Dermatol 120:865–870

    Article  CAS  PubMed  Google Scholar 

  121. Suchak R, O’connor S, Mcnamara C et al (2010) Indolent CD8-positive lymphoid proliferation on the face: part of the spectrum of primary cutaneous small-/medium-sized pleomorphic T-cell lymphoma or a distinct entity? J Cutan Pathol 37:977–981

    Article  PubMed  Google Scholar 

  122. Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375–2390

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Tokura Y, Sawada Y, Shimauchi T (2014) Skin manifestations of adult T-cell leukemia/lymphoma: clinical, cytological and immunological features. J Dermatol 41:19–25

    Article  CAS  PubMed  Google Scholar 

  124. Trautinger F, Knobler R, Willemze R et al (2006) EORTC consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome. Eur J Cancer 42:1014–1030

    Article  PubMed  Google Scholar 

  125. Tripodo C, Iannitto E, Florena AM et al (2009) Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol 6:707–717

    Article  PubMed  Google Scholar 

  126. Trotter MJ, Whittaker SJ, Orchard GE et al (1997) Cutaneous histopathology of Sezary syndrome: a study of 41 cases with a proven circulating T-cell clone. J Cutan Pathol 24:286–291

    Article  CAS  PubMed  Google Scholar 

  127. Van Doorn R, Scheffer E, Willemze R (2002) Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis: a clinicopathologic and follow-up study of 51 patients. Arch Dermatol 138:191–198

    PubMed  Google Scholar 

  128. Van Doorn R, Van Haselen CW, Van Voorst Vader PC et al (2000) Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 136:504–510

    PubMed  Google Scholar 

  129. Van Haselen CW, Toonstra J, Van Der Putte SJ et al (1998) Granulomatous slack skin. Report of three patients with an updated review of the literature. Dermatology 196:382–391

    Article  PubMed  Google Scholar 

  130. Van Vloten WA, Willemze R (2003) The many faces of lymphocytoma cutis. J Eur Acad Dermatol Venereol 17:3–6

    Article  PubMed  Google Scholar 

  131. Vonderheid EC, Bernengo MG, Burg G et al (2002) Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol 46:95–106

    Article  PubMed  Google Scholar 

  132. Wada DA, Law ME, Hsi ED et al (2011) Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies. Mod Pathol 24:596–605

    Article  CAS  PubMed  Google Scholar 

  133. Walsh NM, Prokopetz R, Tron VA et al (1994) Histopathology in erythroderma: review of a series of cases by multiple observers. J Cutan Pathol 21:419–423

    Article  CAS  PubMed  Google Scholar 

  134. Werner B, Massone C, Kerl H et al (2008) Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. J Cutan Pathol 35:1100–1107

    Article  PubMed  Google Scholar 

  135. Willemze R, Jaffe ES, Burg G et al (2005) WHO-EORTC classification for cutaneous lymphomas. Blood 105:3768–3785

    Article  CAS  PubMed  Google Scholar 

  136. Willemze R, Jansen PM, Cerroni L et al (2008) Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 111:838–845

    Article  CAS  PubMed  Google Scholar 

  137. Wobser M, Roth S, Reinartz T et al (2015) CD68 expression is a discriminative feature of indolent cutaneous CD8-positive lymphoid proliferation and distinguishes this lymphoma subtype from other CD8-positive cutaneous lymphomas. Br J Dermatol 172:1573–1580

    Article  CAS  PubMed  Google Scholar 

  138. Wolf IH, Cerroni L, Fink-Puches R et al (2005) Das morphologische Spektrum der kutanen Pseudolymphome. J Dtsch Dermatol Ges 3:710–720 (quiz 721)

    Article  PubMed  Google Scholar 

  139. Wood GS, Tung RM, Haeffner AC et al (1994) Detection of clonal T-cell receptor gamma gene rearrangements in early mycosis fungoides/Sezary syndrome by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE). J Invest Dermatol 103:34–41

    Article  CAS  PubMed  Google Scholar 

  140. Wobser M, Maurus K, Roth S, Appenzeller S, Weyandt G, Goebeler M, Rosenwald A, Geissinger E (2017) Myeloid differentiation primary response 88 mutations in a distinct type of cutaneous marginal-zone lymphoma with a nonclass-switched immunoglobulin M immunophenotype. Br J Dermatol 177:564–566

    Article  CAS  PubMed  Google Scholar 

  141. Mitteldorf C, Kempf W (2017) Cutaneous pseudolymphoma. Surg Pathol Clin 10:455–476

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Histologische Diagnostik, Kempf und Pfaltz, Affolternstr. 56, 8050, Zürich, Schweiz

    Prof. Dr. Werner Kempf

  2. Pathologisches Institut der Universität, Würzburg, Deutschland

    Prof. Dr. Eva Geissinger

Authors
  1. Prof. Dr. Werner Kempf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. Eva Geissinger
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Werner Kempf .

Editor information

Editors and Affiliations

  1. der Universität Würzburg, Pathologisches Institut der Universität Würzburg, Würzburg, Bayern, Germany

    Hans Konrad Müller-Hermelink

  2. Medizinische Hochschule Hannover (MHH) Inst. Pathologie, Hannover, Germany

    Hans H. Kreipe

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kempf, W., Geissinger, E. (2019). Kutane lymphoproliferative und hämatopoietische Erkrankungen. In: Müller-Hermelink, H., Kreipe, H. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85184-4_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-85184-4_38

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85183-7

  • Online ISBN: 978-3-540-85184-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation