Zusammenfassung
Dieses Kapitel beschreibt das Prinzip der Intention-to-Treat Analyse im Vergleich zu anderen Auswertungsstrategien für randomisierte klinische Studien. Es werden allgemeine Empfehlungen für die Auswertung gegeben sowie Implikationen für die Planung und Durchführung klinischer Studien beschrieben. Drei Beispiele klinischer Studien dienen der Illustration verschiedener Auswertungsstrategien.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gotzsche PC, Lang T for the CONSORT Group. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Annals of Internal Medicine 2001; 134: 663-694.
Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz KF, Simel D, Stroup DF. Improving the quality of reporting of randomized controlled trials. The CONSORT Statement. Journal of the American Medical Association 1996; 276: 637-639.
Chene G, Morlat P, Leport C, Hafner R, Dequae L, Charreau I, Aboulker J-P, Luft B, Aubertin J, Vilde J-L, Salamon R, Members of the ANRS 005/ACTG 154 Trial Group. Intention-to-Treat vs. On-Treatment analyses of clinical trial data: experience from a study of Pyrimethamine in the primary prophylaxis of Toxoplasmosis in HIV-infected patients. Controlled Clinical Trials 1998; 19: 233-248.
Coronary Drug Project Research Group. Influence of adherences to treatment and response of cholesterol on mortality in the Coronary Drug Project. New England Journal of Medicine 1980; 303: 1038-1041.
Ellenberg JH. Intention-to-Treat Analysis. In: Armitage P, Colton T (eds). Encyclopedia of Biostatistics. Chichester: Wiley, 1998.
European Coronary Surgery Study Group. Coronary-artery bypass surgery in stable angina pectoris: survival at two years. Lancet 1979; 1: 889-893.
Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. British Medical Journal 1999; 319: 670-674.
ICH E9. Statistical principles for clinical trials. London, UK: International Conference on Harmonisation; 1998. Adopted by CPMP March 1998 (CPMP/ICH/363/96).
Knickerbocker RK. Intention-to-Treat analyses. In: Chow SC (ed). Encyclopedia of Biopharmaceutical Statistics. New York: Marcel Dekker, 2000.
Lewis JA, Machin D. Intention to treat – who schould use ITT? British Journal of Cancer 1993; 68: 647-650.
Marubini E, Valsecchi MG. Analysing survival data from clinical trials and observational studies. Chichester: Wiley, 1995.
Moher D, Schulz KF, Altman DG for the CONSORT Group. The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomized trials. Annals of Internal Medicine 2001; 134: 657-662.
Schumacher M, Bastert G, Bojar H, Hübner K, Olschewski M, Sauerbrei W, Schmoor C, Beyerle C, Neumann RLA, Rauschecker HF for the German Breast Cancer Study Group (GBSG). Randomized 2x2 trial evaluating hormonal treatment and the duration of chemotherapy in node-positive breast cancer patients. Journal of Clinical Oncology 1994; 12: 2086-2093.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schulgen/Kristiansen, G., Schumacher, M. (2008). Intention-to-Treat Analyse. In: Methodik klinischer Studien. Statistik und ihre Anwendungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85136-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-540-85136-3_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-85135-6
Online ISBN: 978-3-540-85136-3
eBook Packages: Life Science and Basic Disciplines (German Language)