The Pathways of Complement

  • Jonathan M. Aitken
  • Tim Clarke
  • Jonathan I. Timmis
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5132)


The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.


Sialic Acid Alternative Pathway Matching Function Attentive Monitoring Polyanionic Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Jonathan M. Aitken
    • 1
  • Tim Clarke
    • 1
  • Jonathan I. Timmis
    • 1
  1. 1.Department of ElectronicsUniversity of York, HeslingtonYorkUK

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