Supporting Computational Systems Science: Genomic Analysis Tool Federations Using Aspects and AOP

  • David Stotts
  • Keith Lee
  • Ivan Rusyn
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4983)


We show how Aspect-Oriented Programming (AOP) and its main concept – the aspect – can be used to effectively construct interoperating collections of scientific tools and models. Such collections, termed “federations”, naturally arise in computational frameworks for bioinformatics problems. Programming modern scientific simulations and models require more domain expertise than can be found in one researcher; often the many researchers needed to create the various computational components of a full solution cannot be gathered to work as a single controlled software development team. Our approach allows individuals to construct their own components and tools, and then have them assembled without alteration (and without coordination of the original programmers) into a federation for the larger final computational solutions. We illustrate the methods with two SNP and haplotype analysis tools written in Python.


Source Code Model Time Step APAP Overdose Compatibility Matrix Model Federation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • David Stotts
    • 1
  • Keith Lee
    • 1
  • Ivan Rusyn
    • 1
  1. 1.Department of Computer Science, and School of Public HealthUniversity of North Carolina at Chapel Hill 

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