Invited Keynote Talk: Haplotype Sharing for Genome-Wide Case-Control Association Studies

  • Andrew S. Allen
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4983)


The computational demands imposed by the large number of markers considered in a genome-wide association study (GWAS) have resulted in an extreme simplification in the types of analyses conducted. While sophisticated methodology may be used to adjust for multiple comparisons, most studies are analyzed one marker at a time using simple tests such as the Cochran-Armitage trend test. Though computationally simple, a significant limitation of such an analysis paradigm is its failure to efficiently use the information contained in the GWAS sample.

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Andrew S. Allen
    • 1
  1. 1.Department of Biostatistics and Bioinformatics, DUMC 3850Duke UniversityDurham

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