Skip to main content
SpringerLink
Log in

Squamous Cell Carcinoma In Situ

  • Chapter
Managing Skin Cancer

  • 1005 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ackerman AB (2003) Solar keratosis is squamous cell carcinoma. Arch Dermatol 139:1216–1217

    Article  PubMed  Google Scholar 

  2. Heaphy MR Jr, Ackerman AB (2000) The nature of solar keratosis: a critical review in historical perspective. J Am Acad Dermatol 43:138–150

    Article  PubMed  Google Scholar 

  3. Memon AA, Tomenson JA, Bothwell J, Friedmann PS (2000) Prevalence of solar damage and actinic keratosis in a Merseyside population. Br J Dermatol 142:1154–1159

    Article  PubMed  CAS  Google Scholar 

  4. Salasche SJ (2000) Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 42:4–7

    Article  PubMed  CAS  Google Scholar 

  5. Frost C, Williams G, Green A (2000) High incidence and regression rates of solar keratoses in a queensland community. J Invest Dermatol 115:273–277

    Article  PubMed  CAS  Google Scholar 

  6. Stockfleth E, Ulrich C, Meyer T, Christophers E (2002a) Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment. Recent Results Cancer Res 160:251–258

    Article  PubMed  CAS  Google Scholar 

  7. Ulrich C, Christophers E, Sterry W, Meyer T, Stockfleth E (2002) Skin diseases in organ transplant patients. Hautarzt 53:524–533

    Article  PubMed  CAS  Google Scholar 

  8. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ (1996) Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor protection. J Invest Dermatol Symp Proc 1:136–142

    CAS  Google Scholar 

  9. Chuang TY, Heinrich LA, Schultz MD, Reizner GT, Kumm RC, Cripps DJ (1992) PUVA and skin cancer. A historical cohort study on 492 patients. J Am Acad Dermatol 26(2 Pt 1):173–177

    Article  PubMed  CAS  Google Scholar 

  10. Jackson S, Storey A (2000) E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage. Oncogene 19:592–598

    Article  PubMed  CAS  Google Scholar 

  11. Jackson S, Harwood C, Thomas M, Banks L, Storey A (2000) Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev 14:3065–3073

    Article  PubMed  CAS  Google Scholar 

  12. Hazard K, Karlsson A, Andersson K, Ekberg H, Dillner J, Forslund O (2007) Cutaneous human papillomaviruses persist on healthy skin. J Invest Dermatol 127(1):116–119

    Article  PubMed  CAS  Google Scholar 

  13. Nindl I, Gottschling M, Stockfleth E (2007) Human papil-lomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations. Dis Markers 23(4):247–259

    PubMed  CAS  Google Scholar 

  14. Braakhuis BJM, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH (2003) A genetic explanation of Slaughter 's concept of field cancerization. Evidence and clinical implications. Cancer Res 63:1727–1730

    PubMed  CAS  Google Scholar 

  15. Berhane T, Halliday GM, Cooke B, Barnetson RSC (2002) Inflammation is associated with progression of actinic kera-toses to squamous cell carcinomas in humans. Br J Dermatol 146:810–815

    Article  PubMed  CAS  Google Scholar 

  16. Ulrich M, Maltusch A, Röwert-Huber J, Gonz ález S, Sterry W, Stockfleth E, Astner S (2007) Actinic keratoses: non-invasive diagnosis for field cancerisation. Br J Dermatol 156(Suppl 3):13–17

    Article  PubMed  Google Scholar 

  17. Röwert-Huber J, Patel MJ, Forschner T, Ulrich C, Eberle J, Kerl H, Sterry W, Stockfleth E (2007) Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclas-sification. Br J Dermatol 156(Suppl 3):8–12

    Article  PubMed  Google Scholar 

  18. Emmett AJ, Broadbent GD (1987) Shave excision of super-ficial solar skin lesions. Plast Reconstr Surg 80:47–54

    Article  PubMed  CAS  Google Scholar 

  19. Dinehart SM (2000) The treatment of actinic keratoses. J Am Acad Dermatol 42:25–28

    Article  PubMed  CAS  Google Scholar 

  20. Drake LA, Ceiley R, Cornelison RL, Dobes WL, Dorner W, Goltz W, Graham G, Lewis CW, Salasche SJ, Chanco Turner ML, Lewery BJ (1995) Guidelines of care for actinic kera-toses. J Am Acad Dermatol 32:95–98

    Article  PubMed  CAS  Google Scholar 

  21. Zouboulis ChC (1999) Principles of cutaneous cryosurgery: an update. Dermatology 198:111–117

    Article  PubMed  CAS  Google Scholar 

  22. Chiarello SE (2000) Cryopeeling (extensive cryosurgery) for treatment of actinic keratoses: An update and comparison. Dermatol Surg 26:728–732

    Article  PubMed  CAS  Google Scholar 

  23. Szeimies RM, Radakovic S, Calzavara-Pinton PG et al (2000) A prospective, randomized study comparing photo-dynamic therapy with Metvix ® to cryotherapy in actinic keratoses. J Eur Acad Dermatol Venereol 14:235

    Google Scholar 

  24. Lubritz RR, Smolewski SA (1982) Cryosurgery cure rate of actinic keratoses. J Am Acad Dermatol 7:631–632

    Article  PubMed  CAS  Google Scholar 

  25. Witheiler DD, Lawrence N, Cox SE, Cruz C, Cockerell CJ, Freeman RG (1997) Long-term efficacy and safety of Jessner 's solution and 35% trichloroacetic acid vs 5% fluo-rouracil in the treatment of widespread facial actinic kera-toses. Dermatol Surg 23:191–196

    Article  PubMed  CAS  Google Scholar 

  26. Lawrence N (2000) New and emerging treatments for pho-toaging. Dermatol Clin 18:99–112

    Article  PubMed  CAS  Google Scholar 

  27. Otley CC, Roenigk RK (1996) Medium-depth chemical peeling. Semin Cutan Med Surg 15:145–154

    Article  PubMed  CAS  Google Scholar 

  28. Stone PA (1998) The use of modified phenol for chemical face peeling. Clin Plast Surg 25:21–44

    PubMed  CAS  Google Scholar 

  29. Iyer S, Friedli A, Bowes L, Kricorian G, Fitzpatrick RE (2004) Full face laser resurfacing: therapy and prophylaxis for actinic keratoses and non-melanoma skin cancer. Lasers Surg Med 34:114–119

    Article  PubMed  Google Scholar 

  30. Wollina U, Konrad H, Karamfilov T (2001) Treatment of common warts and actinic keratoses by Er:YAG laser. J Cutan Laser Ther 3:63–66

    Article  PubMed  CAS  Google Scholar 

  31. Yu TC, Rahman Z, Ross BS (2003) Actinic keratoses –surgical and physical therapeutic modalities. Cutis 71:381–384

    PubMed  Google Scholar 

  32. Fulton JE, Rahimi AD, Helton P, Dahlberg K, Kelly AG (1999) Disappointing results following resurfacing of facial skin with CO2 lasers for prophylaxis of keratoses and cancers. Dermatol Surg 25:729–732

    Article  PubMed  CAS  Google Scholar 

  33. Szeimies RM, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton PG, Zane C, Sidoroff A, Hempel M, Ulrich J, Proebstle T, Meffert H, Mulder M, Salomon D, Dittmar HC, Bauer JW, Kernland K, Braathen L (2002) Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J Am Acad Dermatol 47:258–262

    Article  PubMed  CAS  Google Scholar 

  34. Morton CA, Brown SB, Collins S Ibbotson S, Jenkinson H, Kurwa H, Langmack K, McKenna K, Moseley H, Pearse AD, Stringer M, Taylor DK, Wong G, Rhodes LE (2002) Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol 146:552–567

    Article  PubMed  CAS  Google Scholar 

  35. Pariser DM, Lowe NJ, Stewart DM, Jarrat MT, Lucky AW, Pariser RJ, Yamauchi PS (2003) Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol 48:227–232

    Article  PubMed  Google Scholar 

  36. Freeman M, Vinciullo C, Francis D, Spelman L, Nguyen R, Fergin P, Thai KE, Murrell D, Weightman W, Anderson C, Reid C, Watson A, Foley P (2003) A comparison of photo-dynamic therapy using topical methyl aminolevulinate (Metvix) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study. J Dermatolog Treat 14:99–106

    Article  PubMed  CAS  Google Scholar 

  37. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (2002) Small antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3:196–200

    Article  PubMed  CAS  Google Scholar 

  38. Miller RL, Gerster JF, Owens ML, Slade HB, Tomai MA (1999) Imiquimod applied topically: a novel immune response modi-fier and new class of drug. Int J Immunop harmacol 21:1–14

    Article  CAS  Google Scholar 

  39. Stockfleth E, Meyer T, Benninghoff B, Salasche S, Papadopoulos L, Ulrich C, Christophers E (2002b) A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol 138:1498–1502

    Article  PubMed  CAS  Google Scholar 

  40. Stockfleth E, Christophers E, Benninghoff B, Sterry W (2004b) Low incidence of new actinic keratoses after topical 5% imiquimod cream treatment: a long-term follow-up study. Arch Dermatol 140:1542

    Article  PubMed  Google Scholar 

  41. Lebwohl M, Dinehart S, Whiting D, Lee PK, Tawfik N, Jorizzo J, Lee JH, Fox TL (2004) Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 50(5):714–721

    Article  PubMed  Google Scholar 

  42. Gupta AK (2002) The management of actinic keratoses in the United States with topical fluorouracil: a pharmacoeco-nomic evaluation. Cutis 70:30–36

    PubMed  Google Scholar 

  43. Lawrence N, Cox SE, Cockerell CJ, Freeman RG, Cruz PD Jr (1995) A comparison of the efficacy and safety of Jessner 's solution and 35% trichloroacetic vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Arch Dermatol 131:176–181

    Article  PubMed  CAS  Google Scholar 

  44. Levy S, Furst K, Chern W (2001) A comparison of the skin permeation of three topical 0.5% fluorouracil formulations with that of a 5% formulation. Clin Ther 23:901–907

    Article  PubMed  CAS  Google Scholar 

  45. Jorizzo J, Stewart D, Bucko A, Davis A, Davis SA, Espy P, Hino P, Rodriguez D, Savin R, Stough D, Furst K, Connolly M, Levy S (2002) Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic kera-tosis. Cutis 10:335–339

    Google Scholar 

  46. Loven K, Stein L, Furst K, Levy S (2002) Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther 24:990–1000

    Article  PubMed  CAS  Google Scholar 

  47. Sachsenberg-Studer EM (1999) Tolerance of topical retinal-dehyde in humans. Dermatology 199:S61–63

    Article  Google Scholar 

  48. Sorg O, Tran C, Saurat JH (2001) Cutaneous vitamins A and E in the context of ultraviolet- or chemically-induced oxida-tive stress. Skin Pharmacol Appl Skin Physiol 14:363–372

    Article  PubMed  CAS  Google Scholar 

  49. Moriarty M, Dunn J, Darragh A, Lambe R, Brick I (1982) Etretinate in treatment of actinic keratosis. A double-blind crossover study. Lancet 13:364–365

    Article  Google Scholar 

  50. DiGiovanna JJ (2001) Retinoid chemoprevention in patients at high risk for skin cancer. Med Pediatr Oncol 36:564–567

    Article  PubMed  CAS  Google Scholar 

  51. McNamara IR, Muir J, Galbraith AJ (2002) Acitretin for prophylaxis of cutaneous malignancies after cardiac transplantation. J Heart Lung Transplant 21:1201–1205

    Article  PubMed  Google Scholar 

  52. Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L (2003) IL-1ß-mediated up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflam-mation and oncogenesis. FASEB J 17:2115–2117

    PubMed  CAS  Google Scholar 

  53. Rivers JK, Arlette J, Shear N, Guenther L, Carey W, Poulin Y (2002) Topical treatment of actinic keratoses with 3.0% diclofenac in 2,5% hyaluronan gel. Br J Dermatol 146:94–100

    Article  PubMed  CAS  Google Scholar 

  54. Gebauer K, Brown P, Varigos G (2003) Topical diclofenac in hyaluronan gel for the treatment of solar keratoses. Australas J Dermatol 44:40–45

    Article  PubMed  Google Scholar 

  55. Wolf JE Jr, Taylor JR, Tschen E, Kang S (2001) Topical 3,0% diclofenac in 2,5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol 40:709–713

    Article  PubMed  CAS  Google Scholar 

  56. Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63:8–18

    Article  PubMed  CAS  Google Scholar 

  57. Thompson SC, Jolley D, Marks R (1993) Reduction of solar keratoses by regular sunscreen use. N Engl J Med 329:1147–1151

    Article  PubMed  CAS  Google Scholar 

  58. Ulrich C, Jürgensen JS, Degen A, Hackethal M, Ulrich M, Patel MJ, Eberle J, Terhorst D, Sterry W, Stockfleth E (2009) Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study.;Br J Dermatol 161(Suppl 3):78–84

    Article  PubMed  Google Scholar 

  59. Bowen JT (1912) Precancerous dermatoses: a study of two cases of chronic atypical epithelial proliferation. J Cutan Dis 30:241–255

    Google Scholar 

  60. Cox NH, Eedy DJ, Morton CA (1999) Guidelines for management of Bowen 's disease. Br J Dermatol 141:633–641

    Article  PubMed  CAS  Google Scholar 

  61. Lycka BAS (1989) Bowen 's disease and internal malignancy. A meta analysis. Int J Dermatol 28:531–533

    Article  PubMed  CAS  Google Scholar 

  62. Thestrup-Pedersen K, Ravnborg L, Reymann F (1988) Morbus Bowen. Acta Derm Venereol (Stockh) 68:236–239

    CAS  Google Scholar 

  63. Moreno G, Chia ALK, Lim, Shumack S (2007) Therapeutic options for Bowen 's disease. Australas J Dermatol 48:1–10

    Article  PubMed  Google Scholar 

  64. Rosen T, Harting M, Gibson M (2007) Treatment of Bowen 's disease with topical 5% imiquimod cream. Retrospective study. Dermatol Surg 33:427–432

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Venerology and Allergology, Charité Universty Hospital Berlin, Skin Cancer Center Charité, Charitéplatz 1, Berlin, 10117, Germany

    E. Stockfleth

Authors
  1. E. Stockfleth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. Stockfleth .

Editor information

Editors and Affiliations

  1. Skin Cancer Center Charité, Department of Dermatology, Charité University Medicine Berlin, Charitéplatz 1, Berlin, 10117, Germany

    Eggert Stockfleth

  2. Department of Dermatology, 6620 Main Street, Suite 1425, Houston, TX, 77030, USA

    Theodore Rosen (Chief of VA Dermatology Clinic Professor) (Chief of VA Dermatology Clinic Professor)

  3. Ground Floor, 225 Macquarie Street, Sydney, NSW, 2000, Australia

    Stephen Shumack

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Stockfleth, E. (2010). Squamous Cell Carcinoma In Situ. In: Stockfleth, E., Rosen, T., Shumack, S. (eds) Managing Skin Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79347-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-79347-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-79346-5

  • Online ISBN: 978-3-540-79347-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation