Sensory Nerves pp 261-281 | Cite as

Transient Receptor Potential Channels on Sensory Nerves

  • S.R. EidEmail author
  • D.N. Cortright
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 194)


The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of “thermoTRPs” TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 in nociception. In concert, through the efforts of many industrial and academic teams, a number of agonists and antagonists of these channels have been discovered, paving the way for a better understanding of sensory biology and, potentially, for novel treatments for diseases.


TRPV1 TRPV2 TRPV3 TRPV4 TRPA1 TRPM8 Pain Nociceptors Sensory system Channels Agonists Antagonists 



2-Aminoethoxydiphenyl borate


Complete Freund's adjuvant


Dorsal root ganglion


Phosphatidylinositol 4,5-bisphosphate




Transient receptor potential


Transient receptor potential ankyrin subfamily, member 1


Transient receptor potential melastatin subfamily, member 8


Transient receptor potential vanilloid subfamily, member 1


Transient receptor potential vanilloid subfamily, member 2


Transient receptor potential vanilloid subfamily, member 3


Transient receptor potential vanilloid subfamily, member 4


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Pain Research, Neuroscience Drug DiscoveryMerck Research LaboratoriesWest PointUSA
  2. 2.Department of Biochemistry and Molecular BiologyNeurogen CorporationBranfordUSA

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