Abstract
The fundamental role of calcium ions (Ca2+) in an excitable tissue, the frog heart, was first demonstrated in a series of classical reports by Sydney Ringer in the latter part of the nineteenth century (1882a, b; 1893a, b). Even so, nearly a century elapsed before it was proven that Ca2+ regulated the excitability of primary sensory neurons. In this chapter we review the sites and mechanisms whereby internal and external Ca2+ can directly or indirectly alter the excitability of primary sensory neurons: excitability changes being manifested typically by variations in shape of the action potential or the pattern of its discharge.
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Acknowledgements
We would like to thank Jessica Swartz for her valuable input to this work and for her critique of an earlier version of this manuscript. This work was supported by NIH grants NS22069 (D.W.) and ST32-NS007375 (T.D.G.).
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Gover, T., Moreira, T., Weinreich, D. (2009). Role of Calcium in Regulating Primary Sensory Neuronal Excitability. In: Canning, B., Spina, D. (eds) Sensory Nerves. Handbook of Experimental Pharmacology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79090-7_16
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