Abstract
a novel alginate/poly-L-arginine microcapsules were prepared by emulsification using bovine hemoglobin (Hb) as the model drug, and the impact of the release properties such as the molecular weight of poly-L-arginine, the concentration of sodium alginate and calcium chloride were investigated. The microcapsules made from middle molecular weight of poly-L-arginine (PLA) had obviously sustained release profile. The impact of sodium alginate concentration on the release properties was not obviously, the release rate of microcapsules made with 12% (w/v) CaCl2 were slightly faster, but the accumulative release rate were nearly the same. The microcapsules had so obviously sustained drug release that this novel microcapsules may be used as a promising drug delivery system for hydrophilic proteins and peptides.
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© 2008 Springer-Verlag Berlin Heidelberg
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Wu, W., Liu, W., Wang, S., Liu, Y. (2008). Drug controlled release of novel alginate/poly-L-arginine microcapsules. In: Peng, Y., Weng, X. (eds) 7th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79039-6_7
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DOI: https://doi.org/10.1007/978-3-540-79039-6_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-79038-9
Online ISBN: 978-3-540-79039-6
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