Abstract
As a new drug delivery carrier, medical nanoparticles appears to be very promising and are widely studied. This work was to prepare poly (lactic-co-glycolic) acid (PLGA) nanoparticles for drug loaded paclitaxel using the emulsion solvent evaporation technique. Tocopheryl polyethylene glycol 1000 succinate(TPGS), as a new emulsifier, which has amphiphilic structure comprising lipophilic alkyl tail and hydrophilic polar head portion, played a key role in emulsion technique. The systems were characterized by light scattering analysis for their mean size and size distribution and by scanning electron microscopy for surface morphology. Nanoparticles drug loading efficiency and encapsulation efficiency and ability of in vitro drug release were assessed by ultraviolet spectroscopy. As a result, the nanoparticles were uniformly spherical with average diameter of 250 nm, drug loading efficiency of 4.84%, and encapsulation efficiency of 67.35%. The in vitro release curves of paclitaxel-loaded nanoparticles appeared to be two-staged. In the first day, the initial burst was observed. After that the release of paclitaxel was at a constant rate.
Keywords
- Nanoparticles
- PLGA
- Paclitaxel
- TPGS
- Release Efficiency
This is a preview of subscription content, access via your institution.
Buying options
Preview
Unable to display preview. Download preview PDF.
References
Wani MC, Taylor HL, Wall ME et al. Plant antitumor agents. VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem. Soc 1971, 93:2325–2327
Thigpen JT. Chemotherapy for advanced ovarian cancer: overview of randomized trials. Semin Oncol 2000, 27: 11–16
Ishitobi M, Shin E, Kikkawa N. Metastatic breast cancer with resistance to both anthracycline and docetaxel successfully treated with weakly paclitaxel. Int J Clin Oncol 2001, 6: 55–58
Chang AY, Rubins J, Asbury R et al. Weekly paclitaxel in advanced non-small cell lung cancer. Semin Oncol 2001, 28: 10–13
Gelderblom H, Verweij J, Nooter K. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer 2001, 37: 1590–1598
Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulation. Int J Pharm 2002, 235: 179–192
F. Tewes, E. Munniera, B. Antoona, et al. Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods. Eur J Pharm 2007, 66: 488–492
Zhiping Zhang, Sie Huey Lee, Si-Shen Feng. Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery. Biomaterials 2007, 28: 1889–1899
Khin Yin Win, Si-Shen Feng. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 2005, 26: 2713–2722
L. Mu, S.S. Feng. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel. J Con Rel 2002, 80:129–144
Kai-Hong Huang, Zhao-Hua Zhu, Jian-Hua Liu, et al. preparation and release efficiency of polylactic acid nanoparticle. Chin J Cancer 2005, 24: 1023–1026
E._K. Park, S. B. Lee, Y. M. Lee. Preparation and characterization of methoxy poly (ethylene glycol)/poly (caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials 2005, 26: 1053–1061
Musumeci T., C.A. Ventura, I. Giannone, et al. PLA/PLGA nanoparticles for sustained release of docetaxel. Int J Pharm 2006, 325:172–179
L. Mu, S.S. Feng. A novel controlled release formulation for the anticancer drug paclitaxel: PLGA nanoparticles containing vitamin E TPGS. J Con Rel 2003, 86: 33–48
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ling, Y., Huang, Y. (2008). Preparation and Release Efficiency of Poly (lactic-co-glycolic) Acid Nanoparticles for Drug Loaded Paclitaxel. In: Peng, Y., Weng, X. (eds) 7th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79039-6_129
Download citation
DOI: https://doi.org/10.1007/978-3-540-79039-6_129
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-79038-9
Online ISBN: 978-3-540-79039-6
eBook Packages: EngineeringEngineering (R0)