Skip to main content

Evaluation and Treatment of Recurrent Nasal Polyposis

  • Chapter
  • 1043 Accesses

Abstract

• Nasal polyposis is the defining feature of a more severe subset of chronic rhinosinusitis.

• Patients with primary or recurrent disease should be evaluated for associated disorders such as asthma, allergic fungal rhinosinusitis, aspirin sensitivity, cystic fibrosis, immunoglobulin subclass deficiency, and primary ciliary dyskinesia.

• Oral and intranasal corticosteroids are the cornerstone of medical therapy for patients with chronic rhinosinusitis with nasal polyposis.

• Patients with medically refractory chronic rhinosinusitis with nasal polyposis or allergic fungal rhinosinusitis are surgical candidates.

• Intensive perioperative medical management and selective use of powered instrumentation facilitate safe and effective surgery.

• Close surveillance, early detection of recurrent polyposis, and tailored medical therapy are required to decrease the need for revision surgery and increase the interval between surgeries in refractory cases.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Afzelius BA (2004) Cilia-related diseases. J Pathol 204:470–477

    Article  PubMed  CAS  Google Scholar 

  2. Afzelius BA, Stenram U (2006) Prevalence and genetics of immotile-cilia syndrome and left-handedness. Int J Dev Biol 50:571–573

    Article  PubMed  CAS  Google Scholar 

  3. Allen A, Down G, Newland A, Reynard K, Rousell V, Salmon E, Scott R (2007) Absolute bioavailability of intranasal fluticasone furoate in healthy subjects. Clin Ther 29:1415–1420

    Article  PubMed  CAS  Google Scholar 

  4. Alobid I, Benitez P, Pujols L, Maldonado M, Bernal-Sprekelsen M, Morello A, Picado C, Mullol J (2006) Severe nasal polyposis and its impact on quality of life. The effect of a short course of oral steroids followed by long-term intranasal steroid treatment. Rhinology 44:8–13

    PubMed  Google Scholar 

  5. Aribandi M, McCoy VA, Bazan C 3rd (2007) Imaging features of invasive and noninvasive fungal sinusitis: a review. Radiographics 27:1283–1296

    Article  PubMed  Google Scholar 

  6. Bachert C, Gevaert P, Holtappels G, Cuvelier C, van Cauwenberge P (2000) Nasal polyposis: from cytokines to growth. Am J Rhinol 14:279–290

    Article  PubMed  CAS  Google Scholar 

  7. Baroody FM, Suh SH, Naclerio RM (1997) Total IgE serum levels correlate with sinus mucosal thickness on computerized tomography scans. J Allergy Clin Immunol 100:563–568

    Article  PubMed  CAS  Google Scholar 

  8. Bassichis BA, Marple BF, Mabry RL, Newcomer MT, Schwade ND (2001) Use of immunotherapy in previously treated patients with allergic fungal sinusitis. Otolaryngol Head Neck Surg 125:487–490

    PubMed  CAS  Google Scholar 

  9. Benitez P, Alobid I, de Haro J, Berenguer J, Bernal-Sprekelsen M, Pujols L, Picado C, Mullol J (2006) A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps. Laryngoscope 116:770–775

    Article  PubMed  CAS  Google Scholar 

  10. Benninger MS, Ferguson BJ, Hadley JA, Hamilos DL, Jacobs M, Kennedy DW, Lanza DC, Marple BF, Osguthorpe JD, Stankiewicz JA, Anon J, Denneny J, Emanuel I, Levine H (2003) Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg 129:S1–S32

    Article  PubMed  Google Scholar 

  11. Bent JP 3rd, Kuhn FA (1994) Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg 111:580–588

    Article  PubMed  Google Scholar 

  12. Blomqvist EH, Lundblad L, Anggard A, Haraldsson PO, Stjarne P (2001) A randomized controlled study evaluating medical treatment versus surgical treatment in addition to medical treatment of nasal polyposis. J Allergy Clin Immunol 107:224–228

    Article  PubMed  CAS  Google Scholar 

  13. Bonfils P, Nores JM, Halimi P, Avan P (2003) Corticosteroid treatment in nasal polyposis with a three-year follow-up period. Laryngoscope 113:683–687

    Article  PubMed  CAS  Google Scholar 

  14. Deal RT, Kountakis SE (2004) Significance of nasal polyps in chronic rhinosinusitis: symptoms and surgical outcomes. Laryngoscope 114:1932–1935

    Article  PubMed  Google Scholar 

  15. Desrosiers MY, Salas-Prato M (2001) Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg 125:265–269

    Article  PubMed  CAS  Google Scholar 

  16. Drazen JM, Israel E, O’Byrne PM (1999) Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 340:197–206

    Article  PubMed  CAS  Google Scholar 

  17. Drettner B, Ebbesen A, Nilsson M (1982) Prophylactive treatment with flunisolide after polypectomy. Rhinology 20:149–158

    PubMed  CAS  Google Scholar 

  18. Dursun E, Korkmaz H, Eryilmaz A, Bayiz U, Sertkaya D, Samim E (2003) Clinical predictors of long-term success after endoscopic sinus surgery. Otolaryngol Head Neck Surg 129:526–531

    Article  PubMed  Google Scholar 

  19. Ebbens FA, Scadding GK, Badia L, Hellings PW, Jorissen M, Mullol J, Cardesin A, Bachert C, van Zele TP, Dijkgraaf MG, Lund V, Fokkens WJ (2006) Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118:1149–1156

    Article  PubMed  CAS  Google Scholar 

  20. Fahrenholz JM (2003) Natural history and clinical features of aspirin-exacerbated respiratory disease. Clin Rev Allergy Immunol 24:113–124

    Article  PubMed  CAS  Google Scholar 

  21. Ferguson BJ (2000) Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope 110:799–813

    Article  PubMed  CAS  Google Scholar 

  22. Folker RJ, Marple BF, Mabry RL, Mabry CS (1998) Treatment of allergic fungal sinusitis: a comparison trial of postoperative immunotherapy with specific fungal antigens. Laryngoscope 108:1623–1627

    Article  PubMed  CAS  Google Scholar 

  23. Ghegan MD, Lee FS, Schlosser RJ (2006) Incidence of skull base and orbital erosion in allergic fungal rhinosinusitis (AFRS) and non-AFRS. Otolaryngol Head Neck Surg 134:592–555

    Article  PubMed  Google Scholar 

  24. Handelsman DJ, Conway AJ, Boylan LM, Turtle JR (1984) Young’s syndrome. Obstructive azoospermia and chronic sinopulmonary infections. N Engl J Med 310:3–9

    PubMed  CAS  Google Scholar 

  25. Hedman J, Kaprio J, Poussa T, Nieminen MM (1999) Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 28:717–722

    Article  PubMed  CAS  Google Scholar 

  26. Herrod HG (1993) Clinical significance of IgG subclasses. Curr Opin Pediatr 5:696–699

    Article  PubMed  CAS  Google Scholar 

  27. Karlsson G, Rundcrantz H (1982) A randomized trial of intranasal beclomethasone dipropionate after polypectomy. Rhinology 20:144–148

    PubMed  CAS  Google Scholar 

  28. Keith P, Nieminen J, Hollingworth K, Dolovich J (2000) Efficacy and tolerability of fluticasone propionate nasal drops 400 microgram once daily compared with placebo for the treatment of bilateral polyposis in adults. Clin Exp Allergy 30:1460–1468

    Article  PubMed  CAS  Google Scholar 

  29. Kennedy DW (1992) Prognostic factors, outcomes and staging in ethmoid sinus surgery. Laryngoscope 102:1–18

    PubMed  CAS  Google Scholar 

  30. Kennedy DW, Wright ED, Goldberg AN (2000) Objective and subjective outcomes in surgery for chronic sinusitis. Laryngoscope 110:29–31

    Article  PubMed  CAS  Google Scholar 

  31. King JM, Caldarelli DD, Pigato JB (1994) A review of revision functional endoscopic sinus surgery. Laryngoscope 104:404–408

    Article  PubMed  CAS  Google Scholar 

  32. Kountakis SE, Arango P, Bradley D, Wade ZK, Borish L (2004) Molecular and cellular staging for the severity of chronic rhinosinusitis. Laryngoscope 114:1895–1905

    Article  PubMed  Google Scholar 

  33. Kuhn FA, Javer AR (2000) Allergic fungal sinusitis: a four-year follow-up. Am J Rhinol 14:149–156

    Article  PubMed  CAS  Google Scholar 

  34. Lal D, Baroody FM, Weitzel EK, deTineo M, Naclerio RM (2006) Total IgE levels do not change 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis. Int Arch Allergy Immunol 139:146–148

    Article  PubMed  CAS  Google Scholar 

  35. Larsen PL, Tos M (2004) Origin of nasal polyps: an endoscopic autopsy study. Laryngoscope 114:710–719

    Article  PubMed  Google Scholar 

  36. Lildholdt T, Fogstrup J, Gammelgaard N, Kortholm B, Ulsoe C (1988) Surgical versus medical treatment of nasal polyps. Acta Otolaryngol 105:140–143

    Article  PubMed  CAS  Google Scholar 

  37. Lund VJ, Flood J, Sykes AP, Richards DH (1998) Effect of fluticasone in severe polyposis. Arch Otolaryngol Head Neck Surg 124:513–518

    PubMed  CAS  Google Scholar 

  38. Majima Y (2004) Clinical implications of the immunomodulatory effects of macrolides on sinusitis. Am J Med 117:S20–25S

    Google Scholar 

  39. McMains KC, Kountakis SE (2005) Revision functional endoscopic sinus surgery: objective and subjective surgical outcomes. Am J Rhinol 19:344–347

    PubMed  Google Scholar 

  40. Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, Bachert C, Baraniuk J, Baroody FM, Benninger MS, Brook I, Chowdhury BA, Druce HM, Durham S, Ferguson B, Gwaltney JM Jr, Kaliner M, Kennedy DW, Lund V, Naclerio R, Pawankar R, Piccirillo JF, Rohane P, Simon R, Slavin RG, Togias A, Wald ER, Zinreich SJ; American Academy of Allergy, Asthma and Immunology; American Academy of Otolaryngic Allergy; American Academy of Otolaryngology-Head and Neck Surgery; American College of Allergy, Asthma and Immunology; American Rhinologic Society (2004) Rhinosinusitis: establishing definitions for clinical research and patient care. Otolaryngol Head Neck Surg 131:S1–S62

    Article  PubMed  Google Scholar 

  41. Moses RL, Cornetta A, Atkins JP Jr, Roth M, Rosen MR, Keane WM (1998) Revision endoscopic sinus surgery: the Thomas Jefferson University experience. Ear Nose Throat J 77:190, 193–5, 199–202

    PubMed  Google Scholar 

  42. Mygind N, Dahl R, Bachert C (2000) Nasal polyposis, eosinophil dominated inflammation, and allergy. Thorax 55:S79–S83

    Article  PubMed  Google Scholar 

  43. Nadel DM, Lanza DC, Kennedy DW (1998) Endoscopically guided cultures in chronic sinusitis. Am J Rhinol 12:233–241

    Article  PubMed  CAS  Google Scholar 

  44. Noone PG, Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zariwala MA, Knowles MR (2004) Primary ciliary dyskinesia: diagnostic and phenotypic features. Am J Respir Crit Care Med 169:459–467

    Article  PubMed  Google Scholar 

  45. Nores JM, Avan P, Bonfils P (2003) Medical management of nasal polyposis: a study in a series of 152 consecutive patients. Rhinology 41:97–102

    PubMed  Google Scholar 

  46. Ochs, HD, Stiehm, ER, Winkelstein, JA, Cunningham-Rundles C, Durandy A, Lederman HM, Notarangelo LD, Rawlings DJ, Roifman CM (2004) Antibody deficiencies. In: Stiehm ER, Ochs HD, Winkelstein JA (eds) Immunologic Disorders in Infants and Children (5th edn). Elsevier, Philadelphia, pp 356–426

    Google Scholar 

  47. Palmer JN, Conley DB, Dong RG, Ditto AM, Yarnold PR, Kern RC (2001) Efficacy of endoscopic sinus surgery in the management of patients with asthma and chronic sinusitis. Am J Rhinol 15:49–53

    Article  PubMed  CAS  Google Scholar 

  48. Pant H, Kette FE, Smith WB, Macardle PJ, Wormald PJ (2006) Eosinophilic mucus chronic rhinosinusitis: clinical subgroups or a homogeneous pathogenic entity? Laryngoscope 116:1241–1247

    Article  PubMed  Google Scholar 

  49. Parnes SM, Chuma AV (2000) Acute effects of antileukotrienes on sinonasal polyposis and sinusitis. Ear Nose Throat J 79:18–20, 24–5

    PubMed  Google Scholar 

  50. Penttila M, Poulsen P, Hollingworth K, Holmstrom M (2000) Dose-related efficacy and tolerability of fluticasone propionate nasal drops 400 microg once daily and twice daily in the treatment of bilateral nasal polyposis: a placebo-controlled randomized study in adult patients. Clin Exp Allergy 30:94–102

    Article  PubMed  CAS  Google Scholar 

  51. Ponikau JU, Sherris DA, Weaver A, Kita H (2005) Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol 115:125–131

    Article  PubMed  CAS  Google Scholar 

  52. Poznanovic SA, Kingdom TT (2007) Total IgE levels and peripheral eosinophilia: correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. Arch Otolaryngol Head Neck Surg 133:701–704

    Article  PubMed  Google Scholar 

  53. Ragab SM, Lund VJ, Scadding G (2004) Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial. Laryngoscope 114:923–930

    Article  PubMed  Google Scholar 

  54. Ratjen F, Doring G (2003) Cystic fibrosis. Lancet 361:681–689

    Article  PubMed  CAS  Google Scholar 

  55. Ryan MW, Marple BF (2007) Allergic fungal rhinosinusitis: diagnosis and management. Curr Opin Otolaryngol Head Neck Surg 15:18–22

    Article  PubMed  Google Scholar 

  56. Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD (1991) Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 325:1067–1071

    PubMed  CAS  Google Scholar 

  57. Senior BA, Kennedy DW, Tanabodee J, Kroger H, Hassab M, Lanza DC (1999) Long-term impact of functional endoscopic sinus surgery on asthma. Otolaryngol Head Neck Surg 121:66–68

    Article  PubMed  CAS  Google Scholar 

  58. Settipane GA (1987) Nasal polyps: epidemiology, pathology, immunology, and treatment. Am J Rhinol 1:119–126

    Article  Google Scholar 

  59. Solares CA, Batra PS, Hall GS, Citardi MJ (2006) Treatment of chronic rhinosinusitis exacerbations due to methicillin-resistant Staphylococcus aureus with mupirocin irrigations. Am J Otolaryngol 27:161–165

    Article  PubMed  CAS  Google Scholar 

  60. Stevenson DD (2003) Aspirin desensitization in patients with AERD. Clin Rev Allergy Immunol 24:159–168

    Article  PubMed  CAS  Google Scholar 

  61. Subramanian HN, Schechtman KB, Hamilos DL (2002) A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis. Am J Rhinol 16:303–312

    PubMed  Google Scholar 

  62. Sunyer J, Anto JM, Sabria J, Roca J, Morell F, Rodriguez-Roisin R, Rodrigo MJ (1995) Relationship between serum IgE and airway responsiveness in adults with asthma. J Allergy Clin Immunol 95:699–706

    Article  PubMed  CAS  Google Scholar 

  63. Sweet JM, Stevenson DD, Simon RA, Mathison DA (1990) Long-term effects of aspirin desensitization – treatment for aspirin-sensitive rhinosinusitis-asthma. J Allergy Clin Immunol 85:59–65

    Article  PubMed  CAS  Google Scholar 

  64. Uri N, Cohen-Kerem R, Barzilai G, Greenberg E, Doweck I, Weiler-Ravell D (2002) Functional endoscopic sinus surgery in the treatment of massive polyposis in asthmatic patients. J Laryngol Otol 116:185–189

    Article  PubMed  Google Scholar 

  65. Van Camp C, Clement PA (1994) Results of oral steroid treatment in nasal polyposis. Rhinology 32:5–9

    PubMed  Google Scholar 

  66. Vining EM (2006) Evolution of medical management of chronic rhinosinusitis. Ann Otol Rhinol Laryngol Suppl 196:54–60

    PubMed  Google Scholar 

  67. Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H (2004) Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 113:1122–1128

    Article  PubMed  CAS  Google Scholar 

  68. Wright ED, Agrawal S (2007) Impact of perioperative systemic steroids on surgical outcomes in patients with chronic rhinosinusitis with polyposis: evaluation with the novel Perioperative Sinus Endoscopy (POSE) scoring system. Laryngoscope 117:1–28

    Article  PubMed  CAS  Google Scholar 

  69. Yamada T, Fujieda S, Mori S, Yamamoto H, Saito H (2000) Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage. Am J Rhinol 14:143–148

    Article  PubMed  CAS  Google Scholar 

  70. Yung MW, Gould J, Upton GJ (2002) Nasal polyposis in children with cystic fibrosis: a long-term follow-up study. Ann Otol Rhinol Laryngol 111:1081–1086

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Roediger, F., Goldberg, A. (2008). Evaluation and Treatment of Recurrent Nasal Polyposis. In: Revision Sinus Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78931-4_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-78931-4_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78930-7

  • Online ISBN: 978-3-540-78931-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics