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Effects of Genetic Divergence in Identifying Ancestral Origin Using HAPAA

  • Andreas Sundquist
  • Eugene Fratkin
  • Chuong B. Do
  • Serafim Batzoglou
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4955)

Abstract

Human population migration, adaptation, and admixture have a chaotic and mostly undocumented history, but we are at the cusp of an era where we will be able to unlock these records from our genomes. An admixed individual’s genome with ancestors from isolated populations is a mosaic of chromosomal blocks, each following the statistical properties of variation seen in those populations. By analyzing polymorphisms in the admixed individual against those seen in representatives from the populations, we can infer the ancestral source of the individual’s haploblocks. Several methods have emerged recently that use SNPs as a basis for variation to infer the ancestral population composition of admixed individuals.

Keywords

Genetic Divergence Haplotypic Variation Discrete Mathematic Individual Genotype Ancestral Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Andreas Sundquist
    • 1
  • Eugene Fratkin
    • 1
  • Chuong B. Do
    • 1
  • Serafim Batzoglou
    • 1
  1. 1.Department of Computer ScienceStanford UniversityStanfordUSA

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