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Beeinflussung der Spindeldynamik durch CK1 Inhibitoren alleine und in Kombination mit Spindelgiften: Ein Ansatzpunkt für die Entwicklung neuer Konzepte in der Tumortherapie?

  • Conference paper
Chirurgisches Forum 2008

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 37))

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Abstract

Members of the CK1 family are involved in the regulation of many different biological processes. Therefore, they are attractive targets for the development of new inhibitors. CK1 specific inhibitors might provide a powerful tool in treating various diseases, including cancer.

IC261 (3-[2,4,6-(trimethoxyphenyl)methylidenyl]-indolin-2-one) inhibits CK1δ and ε already in the low micromolar range. Its high potential to inhibit the growth of various tumour cells could be explained in part by its ability to inhibit microtubule dynamics in both, interphase and mitotic cells. Therefore, in this study the effects of IC261 on microtubule dynamics in interphase and mitotic cells have been analyzed.

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Literatur

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Author information

Authors and Affiliations

  1. Max Planck Institut für molekulare Zellbiologie und Genetik, D-01307, Dresden

    M. Stöter

  2. Klink für Allgemein-, Viszeral- und Transplantationschirurgie am Chirurgischen Zentrum, Universität Ulm, Steinhövelstr. 9, D-89075, Ulm

    PD Dr. Uwe Knippschild, C. Brockschmidt & D. Henne-Bruns

Authors
  1. PD Dr. Uwe Knippschild
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  2. C. Brockschmidt
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  3. D. Henne-Bruns
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  4. M. Stöter
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Editor information

Editors and Affiliations

  1. Klinikum Pforzheim, Kanzlerstraße 2-6, 75175, Pforzheim

    R. Arbogast (Direktor der chirurgischen Klinik) (Direktor der chirurgischen Klinik)

  2. Medizinische Fakultät Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden

    H. K. Schackert (Leiter der Abteilung Chirurgische Forschung) (Leiter der Abteilung Chirurgische Forschung)

  3. Geschäftsstelle, Deutsche Gesellschaft für Chirurgie, Luisenstraße 58/59, 10117, Berlin

    H. Bauer

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© 2008 Springer Medizin Verlag Heidelberg

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Knippschild, U., Brockschmidt, C., Henne-Bruns, D., Stöter, M. (2008). Beeinflussung der Spindeldynamik durch CK1 Inhibitoren alleine und in Kombination mit Spindelgiften: Ein Ansatzpunkt für die Entwicklung neuer Konzepte in der Tumortherapie?. In: Arbogast, R., Schackert, H.K., Bauer, H. (eds) Chirurgisches Forum 2008. Deutsche Gesellschaft für Chirurgie, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78833-1_46

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  • DOI: https://doi.org/10.1007/978-3-540-78833-1_46

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78821-8

  • Online ISBN: 978-3-540-78833-1

  • eBook Packages: Medicine (German Language)

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