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α-Defensine erhöhen invasives Potential von Kolon-Karzinomen in-vitro

  • Conference paper
Chirurgisches Forum 2008

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 37))

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Abstract

Expression of Human Neutrophil Peptides (HNP)1–3 was recently found to be associated with development of colorectal cancer. The aim of this study is to investigate the effects of α-defensins on migration of colorectal cancer cells in vitro. A modified Boyden chamber assay was used for the tests. HNP1–3 was added to HT29 colon cancer cells in concentrations of 5, 10, 15 und 30 µg/ml. Migration was raised in all concentrations compared to control groups but reached its climax at a concentration of 15 µg/ml (44.9 ± 7.8 versus 21.6 ± 6.0, P < 0.007). Results suggest that HNP1–3 adding on CRC cells can modulate their migratory behavior in a dose-dependant manner. An increased migration, as shown here, leaves a higher probability of metastatic induction in vivo.

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Literatur

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Author information

Authors and Affiliations

  1. Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, Erlanger Allee 101, 07747, Jena

    Dr. med. Henning Mothes, R. Kaufmann & U. Settmacher

Authors
  1. Dr. med. Henning Mothes
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  2. R. Kaufmann
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  3. U. Settmacher
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Editor information

Editors and Affiliations

  1. Klinikum Pforzheim, Kanzlerstraße 2-6, 75175, Pforzheim

    R. Arbogast (Direktor der chirurgischen Klinik) (Direktor der chirurgischen Klinik)

  2. Medizinische Fakultät Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden

    H. K. Schackert (Leiter der Abteilung Chirurgische Forschung) (Leiter der Abteilung Chirurgische Forschung)

  3. Geschäftsstelle, Deutsche Gesellschaft für Chirurgie, Luisenstraße 58/59, 10117, Berlin

    H. Bauer

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© 2008 Springer Medizin Verlag Heidelberg

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Mothes, H., Kaufmann, R., Settmacher, U. (2008). α-Defensine erhöhen invasives Potential von Kolon-Karzinomen in-vitro. In: Arbogast, R., Schackert, H.K., Bauer, H. (eds) Chirurgisches Forum 2008. Deutsche Gesellschaft für Chirurgie, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78833-1_25

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  • DOI: https://doi.org/10.1007/978-3-540-78833-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78821-8

  • Online ISBN: 978-3-540-78833-1

  • eBook Packages: Medicine (German Language)

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