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Charakterisierung molekularer Mechanismen der anti-angiogenen Aktivität von GBP-1 in Endothelzellen

  • Conference paper
Chirurgisches Forum 2008

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 37))

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Abstract

Human guanylate binding protein-1 (GBP-1) exerts potent anti-angiogenic properties in human endothelial cells (EC) through inhibition of EC invasiveness and proliferation. To date, the molecular mechanisms of these anti-angiogenic activities of GBP-1 have not been fully elucidated. Comparative transcriptome analyses revealed that integrin alpha4 (ITGA4) is a specific GBP-1 up-regulated gene. Additionally, we could show that GBP-1 is necessary and sufficient to inhibit spreading and motility of HUVEC on fibronectin through induction of ITGA4 expression. These findings provide a novel mechanism to explain the anti-invasive activity of GBP-1 in EC.

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Literatur

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Author information

Authors and Affiliations

  1. Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen-Nuremberg, Schwabachanlage 10, 91054, Erlangen, Germany

    Kristina Weinländer, E. Naschberger, M. H. Lehmann, W. Hohenberger & M. Stürzl

Authors
  1. Kristina Weinländer
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  2. E. Naschberger
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  3. M. H. Lehmann
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  4. W. Hohenberger
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  5. M. Stürzl
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Editor information

Editors and Affiliations

  1. Klinikum Pforzheim, Kanzlerstraße 2-6, 75175, Pforzheim

    R. Arbogast (Direktor der chirurgischen Klinik) (Direktor der chirurgischen Klinik)

  2. Medizinische Fakultät Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden

    H. K. Schackert (Leiter der Abteilung Chirurgische Forschung) (Leiter der Abteilung Chirurgische Forschung)

  3. Geschäftsstelle, Deutsche Gesellschaft für Chirurgie, Luisenstraße 58/59, 10117, Berlin

    H. Bauer

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© 2008 Springer Medizin Verlag Heidelberg

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Weinländer, K., Naschberger, E., Lehmann, M.H., Hohenberger, W., Stürzl, M. (2008). Charakterisierung molekularer Mechanismen der anti-angiogenen Aktivität von GBP-1 in Endothelzellen. In: Arbogast, R., Schackert, H.K., Bauer, H. (eds) Chirurgisches Forum 2008. Deutsche Gesellschaft für Chirurgie, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78833-1_15

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  • DOI: https://doi.org/10.1007/978-3-540-78833-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78821-8

  • Online ISBN: 978-3-540-78833-1

  • eBook Packages: Medicine (German Language)

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